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Hinton Lab

Research Covers & Publications

Hinton Lab Journal Articles

    1. Shao, B., Killion, M., Oliver, A., Vang, C., Zeleke, F., Neikirk, K., Vue, Z., Garza-Lopez, E., Shao, J. Q., Mungai, M., Lam, J., Williams, Q., Altamura, C. T., Whiteside, A., Kabugi, K., McKenzie, J., Koh, A., Scudese, E., Vang, L., Marshall, A. G., … Hinton, A., Jr (2024). Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes. Journal of Cellular Physiology, 2023.05.20.541602. https://doi.org/10.1101/2023.05.20.541602 (Cover Article, In Press)
    2. Hinton, A.*, Jr, Katti, P.*, Mungai, M.*, Hall, D. D., Koval, O., Shao, J., Vue, Z., Lopez, E. G., Rostami, R., Neikirk, K., Ponce, J., Streeter, J., Schickling, B., Bacevac, S., Grueter, C., Marshall, A., Beasley, H. K., Do Koo, Y., Bodine, S. C., Nava, N. G. R., … Abel, E. D. (2024). ATF4-dependent increase in mitochondrial-endoplasmic reticulum tethering following OPA1 deletion in skeletal muscle. Journal of cellular physiology, 239(4), e31204. https://doi.org/10.1002/jcp.31204 (Front Cover and Inside Cover)
    3. Wenegieme, T. Y., Elased, D., McMichael, K. E., Rockwood, J., Hasrat, K., Ume, A. C., Marshall, A. G., Neikirk, K., Kirabo, A., Elased, K. M., Hinton, A., Jr, & Williams, C. R. (2024). Strategies for Inducing and Validating Zinc Deficiency and Zinc Repletion. American journal of physiology. Heart and circulatory physiology, 10.1152/ajpheart.00025.2024. https://doi.org/10.1152/ajpheart.00025.2024
    4. Vue, Z., Garza-Lopez, E., Neikirk, K., Katti, P., Vang, L., Beasley, H., Shao, J., Marshall, A. G., Crabtree, A., Murphy, A. C., Jenkins, B. C., Prasad, P., Evans, C., Taylor, B., Mungai, M., Killion, M., Stephens, D., Christensen, T. A., Lam, J., Rodriguez, B., … Hinton, A., Jr (2023). 3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex. Aging cell, e14009. https://doi.org/10.1111/acel.14009 (Cover Article)
    5. Crabtree, A., Neikirk, K., Marshall, A. G., Vang, L., Whiteside, A. J., Williams, Q., Altamura, C. T., Owens, T. C., Stephens, D., Shao, B., Koh, A., Killion, M., Lopez, E. G., Lam, J., Rodriguez, B., Mungai, M., Stanley, J., Dean, E. D., Koh, H. J., Gaddy, J. A., … Hinton, A., Jr (2023). Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue. Advanced biology, e2300186. https://doi.org/10.1002/adbi.202300186 (Cover Article)
    6. Stephens, D. C., Mungai, M., Crabtree, A., Beasley, H. K., Garza-Lopez, E., Vang, L., Neikirk, K., Vue, Z., Vue, N., Marshall, A. G., Turner, K., Shao, J. Q., Sarker, B., Murray, S., Gaddy, J. A., Davis, J., Damo, S. M., & Hinton, A. O., Jr (2023). Protocol for isolating mice skeletal muscle myoblasts and myotubes via differential antibody validation. STAR protocols, 4(4), 102591. https://doi.org/10.1016/j.xpro.2023.102591
    7. Stephens, V. R., Moore, R. E., Spicer, S. K., Talbert, J. A., Lu, J., Chinni, R., Chambers, S. A., Townsend, S. D., Manning, S. D., Rogers, L. M., Aronoff, D. M., Vue, Z., Neikirk, K., Hinton, A. O., Damo, S. M., Noble, K. N., Eastman, A. J., McCallister, M. M., Osteen, K. G., & Gaddy, J. A. (2023). Environmental Toxicant Exposure Paralyzes Human Placental Macrophage Responses to Microbial Threat. ACS Infectious Diseases. https://doi.org/10.1021/acsinfecdis.3c00490
    8. Vue, Z., Neikirk, K., Vang, L., Garza-Lopez, E., Christensen, T. A., Shao, J., Lam, J., Beasley, H. K., Marshall, A. G., Crabtree, A., Anudokem, J., Jr, Rodriguez, B., Kirk, B., Bacevac, S., Barongan, T., Shao, B., Stephens, D. C., Kabugi, K., Koh, H. J., Koh, A., … Hinton, A., Jr (2023). Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging. American journal of physiology. Heart and circulatory physiology, 325(5), H965–H982. https://doi.org/10.1152/ajpheart.00202.2023 (Spotlight Cover Article)
    9. Marshall, A. G., Neikirk, K., Vue, Z., Beasley, H. K., Garza-Lopez, E., Vang, L., Barongan, T., Evans, Z., Crabtree, A., Spencer, E., Anudokem, J., Jr, Parker, R., Davis, J., Stephens, D., Damo, S., Pham, T. T., Gomez, J. A., Exil, V., Dai, D. F., Murray, S. A., … Hinton, A.*, Reddy, A. K. (2023). Cardiovascular hemodynamics in mice with tumor necrosis factor receptor-associated factor 2 mediated cytoprotection in the heart. Frontiers in cardiovascular medicine, 10, 1064640. https://doi.org/10.3389/fcvm.2023.1064640
    10. Robertson, G. L., Riffle, S., Patel, M., Marshall, A., Beasley, H., Garza-Lopez, E., Shao, J., Vue, Z., Hinton, A.O., Mears, J.A., & Gama, V. (2023). DRP1-mediated mitochondrial fission is essential to maintain cristae morphology and bioenergetics. Journal of Cell Science,
    11. Neikirk, K., Vue, Z., Katti, P., Shao, J., Christensen, T. A., Lopez, E. G., Marshall, A., Palavicino-Maggio, C.B., Ponce, J., Alghanem, A., Vang, L., Beasley, H.K., Rodman, T., Mungai, M., Correia, M., Exil, V., Murray, S.A., Salisbury, J.L., Glancy, B., Pereira, R.O., Abel, E.D. & Hinton, A. (2023). Systematic Transmission Electron Microscopy-Based Identification of Cellular Degradation Machinery. Advanced Biology. DOI: https://doi.org/10.1002/adbi.202200221 (Cover Article)
    12. Hinton, A., Katti, P., Christensen, T. A., Mungai, M., Shao, J., Zhang, L., Trusin, S., Alghanem, A., Jaspersen, A., Geroux, R., Neikirk, K., Biete, M., Garza-Lopez, E., Vue, Z., Beasley, H., Marshall, A., Hicsasmaz, I., Edmonds, R.A.C., Dailes, A., Koo, Y., Bacevac, S., Salisbury, J.L., Pereira, R.O., Glancy, B., Trushina, E., & Abel, E. D. (2023). A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells. Advanced Biology. DOI: https://doi.org/10.1002/adbi.202200202 (Cover Article)
    13. Ji, X. Y., Zheng, D., Ni, R., Wang, J. X., Shao, J. Q., Vue, Z., Hinton, A., Jr, Song, L. S., Fan, G. C., Chakrabarti, S., Su, Z. L., & Peng, T. Q. (2022). Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy. Acta pharmacologica Sinica, 43(11), 2873–2884. https://doi.org/10.1038/s41401-022-00965-9
    14. Phillips, M. A., Arnold, K. R., Vue, Z., Beasley, H. K., Garza-Lopez, E., Marshall, A. G., Morton, D. J., McReynolds, M. R., Barter, T. T., & Hinton, A., Jr (2022). Combining Metabolomics and Experimental Evolution Reveals Key Mechanisms Underlying Longevity Differences in Laboratory EvolvedDrosophila melanogaster  International journal of molecular sciences, 23(3), 1067. https://doi.org/10.3390/ijms23031067
    15. Garza-Lopez, E., Vue, Z., Katti, P., Neikirk, K., Biete, M., Lam, J., Beasley, H. K., Marshall, A. G., Rodman, T. A., Christensen, T. A., Salisbury, J. L., Vang, L., Mungai, M., AshShareef, S., Murray, S. A., Shao, J., Streeter, J., Glancy, B., Pereira, R. O., Abel, E. D., … Hinton, A., Jr (2021). Protocols for Generating Surfaces and Measuring 3D Organelle Morphology Using Amira.Cells, 11(1), 65. https://doi.org/10.3390/cells11010065
    16. Lam, J., Katti, P., Biete, M., Mungai, M., AshShareef, S., Neikirk, K., Garza Lopez, E., Vue, Z., Christensen, T. A., Beasley, H. K., Rodman, T. A., Murray, S. A., Salisbury, J. L., Glancy, B., Shao, J., Pereira, R. O., Abel, E. D., & Hinton, A., Jr (2021). A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ.Cells, 10(9), 2177. https://doi.org/10.3390/cells10092177
    17. Bhardwaj, G., Penniman, C. M., Jena, J., Suarez Beltran, P. A., Foster, C., Poro, K., Junck, T. L., Hinton, A. O., Jr, Souvenir, R., Fuqua, J. D., Morales, P. E., Bravo-Sagua, R., Sivitz, W. I., Lira, V. A., Abel, E. D., & O’Neill, B. T. (2021). Insulin and IGF-1 receptors regulate complex I-dependent mitochondrial bioenergetics and supercomplexes via FoxOs in muscle.The Journal of clinical investigation, 131(18), e146415. https://doi.org/10.1172/JCI146415
    18. Carter, C. S., Huang, S. C., Searby, C. C., Cassaidy, B., Miller, M. J., Grzesik, W. J., Piorczynski, T. B., Pak, T. K., Walsh, S. A., Acevedo, M., Zhang, Q., Mapuskar, K. A., Milne, G. L., Hinton, A. O., Jr, Guo, D. F., Weiss, R., Bradberry, K., Taylor, E. B., Rauckhorst, A. J., Dick, D. W., … Sheffield, V. C. (2021). Counterpoint: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes.American journal of physiology. Endocrinology and metabolism, 320(5), E1001–E1002. https://doi.org/10.1152/ajpendo.00110.2021
    19. Carter, C. S., Huang, S. C., Searby, C. C., Cassaidy, B., Miller, M. J., Grzesik, W. J., Piorczynski, T. B., Pak, T. K., Walsh, S. A., Acevedo, M., Zhang, Q., Mapuskar, K. A., Milne, G. L., Hinton, A. O., Jr, Guo, D. F., Weiss, R., Bradberry, K., Taylor, E. B., Rauckhorst, A. J., Dick, D. W., … Sheffield, V. C. (2021). Reply to Petersen et al.: An alternative hypothesis for why exposure to static magnetic and electric fields treats type 2 diabetes.American journal of physiology. Endocrinology and metabolism, 320(5), E1004–E1005. https://doi.org/10.1152/ajpendo.00119.2021
    20. Kumar, A., Xie, L., Ta, C. M., Hinton, A. O., Gunasekar, S. K., Minerath, R. A., Shen, K., Maurer, J. M., Grueter, C. E., Abel, E. D., Meyer, G., & Sah, R. (2020). SWELL1 regulates skeletal muscle cell size, intracellular signaling, adiposity and glucose metabolism.eLife, 9, e58941. https://doi.org/10.7554/eLife.58941
    21. Ponce, J. M., Coen, G., Spitler, K. M., Dragisic, N., Martins, I., Hinton, A., Jr, Mungai, M., Tadinada, S. M., Zhang, H., Oudit, G. Y., Song, L. S., Li, N., Sicinski, P., Strack, S., Abel, E. D., Mitchell, C., Hall, D. D., & Grueter, C. E. (2020). Stress-Induced Cyclin C Translocation Regulates Cardiac Mitochondrial Dynamics.Journal of the American Heart Association, 9(7), e014366. https://doi.org/10.1161/JAHA.119.014366
    22. Carter, C. S., Huang, S. C., Searby, C. C., Cassaidy, B., Miller, M. J., Grzesik, W. J., Piorczynski, T. B., Pak, T. K., Walsh, S. A., Acevedo, M., Zhang, Q., Mapuskar, K. A., Milne, G. L., Hinton, A. O., Jr, Guo, D. F., Weiss, R., Bradberry, K., Taylor, E. B., Rauckhorst, A. J., Dick, D. W., … Sheffield, V. C. (2020). Exposure to Static Magnetic and Electric Fields Treats Type 2 Diabetes.Cell metabolism, 32(6), 1076. https://doi.org/10.1016/j.cmet.2020.11.001 (Cover Article)
    23. Yang, Y., van der Klaauw, A. A., Zhu, L., Cacciottolo, T. M., He, Y., Stadler, L., Wang, C., Xu, P., Saito, K., Hinton, A., Jr, Yan, X., Keogh, J. M., Henning, E., Banton, M. C., Hendricks, A. E., Bochukova, E. G., Mistry, V., Lawler, K. L., Liao, L., Xu, J., … Xu, Y. (2019). Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis.Nature communications, 10(1), 1718. https://doi.org/10.1038/s41467-019-08737-6
    24. Wang, C., He, Y., Xu, P., Yang, Y., Saito, K., Xia, Y., Yan, X., Hinton, A., Jr, Yan, C., Ding, H., Yu, L., Shu, G., Gupta, R., Wu, Q., Tong, Q., Lagor, W. R., Flores, E. R., & Xu, Y. (2018). TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis.Nature communications, 9(1), 1544. https://doi.org/10.1038/s41467-018-03796-7
    25. Xu, P., He, Y., Cao, X., Valencia-Torres, L., Yan, X., Saito, K., Wang, C., Yang, Y., Hinton, A., Jr, Zhu, L., Shu, G., Myers, M. G., Jr, Wu, Q., Tong, Q., Heisler, L. K., & Xu, Y. (2017). Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice.Biological psychiatry, 81(9), 737–747. https://doi.org/10.1016/j.biopsych.2016.06.005
    26. Saito, K., He, Y., Yang, Y., Zhu, L., Wang, C., Xu, P., Hinton, A. O., Yan, X., Zhao, J., Fukuda, M., Tong, Q., Clegg, D. J., & Xu, Y. (2016). PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice.Scientific reports, 6, 23459. https://doi.org/10.1038/srep23459
    27. Saito, K., He, Y., Yan, X., Yang, Y., Wang, C., Xu, P., Hinton, A. O., Jr, Shu, G., Yu, L., Tong, Q., & Xu, Y. (2016). Visualizing estrogen receptor-α-expressing neurons using a new ERα-ZsGreen reporter mouse line.Metabolism: clinical and experimental, 65(4), 522–532. https://doi.org/10.1016/j.metabol.2015.12.011
    28. Hinton, A. O., Jr, Yang, Y., Quick, A. P., Xu, P., Reddy, C. L., Yan, X., Reynolds, C. L., Tong, Q., Zhu, L., Xu, J., Wehrens, X. H., Xu, Y., & Reddy, A. K. (2016). SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice.PloS one, 11(12), e0168644. https://doi.org/10.1371/journal.pone.0168644
    29. Hinton, A. O., Jr, He, Y., Xia, Y., Xu, P., Yang, Y., Saito, K., Wang, C., Yan, X., Shu, G., Henderson, A., Clegg, D. J., Khan, S. A., Reynolds, C., Wu, Q., Tong, Q., & Xu, Y. (2016). Estrogen Receptor-α in the Medial Amygdala Prevents Stress-Induced Elevations in Blood Pressure in Females. Hypertension(Dallas, Tex. : 1979), 67(6), 1321–1330.
    30. Yan, C., He, Y., Xu, Y., Shu, G., Wang, C., Yang, Y., Saito, K., Xu, P., Hinton, A. O., Jr, Yan, X., Yu, L., Wu, Q., Tso, P., Tong, Q., & Xu, Y. (2016). Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates Pro-Opiomelanocortin Neurons in the Arcuate Nucleus.Neuroendocrinology, 103(5), 476–488. https://doi.org/10.1159/000439436
    31. He, Y., Shu, G., Yang, Y., Xu, P., Xia, Y., Wang, C., Saito, K., Hinton, A., Jr, Yan, X., Liu, C., Wu, Q., Tong, Q., & Xu, Y. (2016). A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism.Cell reports, 17(7), 1807–1818. https://doi.org/10.1016/j.celrep.2016.10.044
    32. Zhu, L., Xu, P., Cao, X., Yang, Y., Hinton, A. O., Jr, Xia, Y., Saito, K., Yan, X., Zou, F., Ding, H., Wang, C., Yan, C., Saha, P., Khan, S. A., Zhao, J., Fukuda, M., Tong, Q., Clegg, D. J., Chan, L., & Xu, Y. (2015). The ERα-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice.Endocrinology, 156(12), 4474–4491. https://doi.org/10.1210/en.2015-1660
    33. Xu, P., Cao, X., He, Y., Zhu, L., Yang, Y., Saito, K., Wang, C., Yan, X., Hinton, A. O., Jr, Zou, F., Ding, H., Xia, Y., Yan, C., Shu, G., Wu, S. P., Yang, B., Feng, Y., Clegg, D. J., DeMarchi, R., Khan, S. A., … Xu, Y. (2015). Estrogen receptor-α in medial amygdala neurons regulates body weight.The Journal of clinical investigation, 125(7), 2861–2876. https://doi.org/10.1172/JCI80941
    34. Yan, C., Yang, Y., Saito, K., Xu, P., Wang, C., Hinton, A. O., Jr, Yan, X., Wu, Q., Tong, Q., Elmquist, J. K., Fukuda, M., & Xu, Y. (2015). Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice.British journal of pharmacology, 172(14), 3510–3521. https://doi.org/10.1111/bph.13141
    35. Zhu, L., Zou, F., Yang, Y., Xu, P., Saito, K., Othrell Hinton, A., Jr, Yan, X., Ding, H., Wu, Q., Fukuda, M., Sun, Z., Tong, Q., & Xu, Y. (2015). Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice.Endocrinology, 156(6), 2114–2123. https://doi.org/10.1210/en.2014-1922
    36. Cao, X., Xu, P., Oyola, M. G., Xia, Y., Yan, X., Saito, K., Zou, F., Wang, C., Yang, Y., Hinton, A., Jr, Yan, C., Ding, H., Zhu, L., Yu, L., Yang, B., Feng, Y., Clegg, D. J., Khan, S., DiMarchi, R., Mani, S. K., … Xu, Y. (2014). Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice.The Journal of clinical investigation, 124(10), 4351–4362. https://doi.org/10.1172/JCI74726
    37. Bu, H., Shu, B., Gao, F., Liu, C., Guan, X., Ke, C., Cao, F., Hinton, A. O., Jr, Xiang, H., Yang, H., Tian, X., & Tian, Y. (2014). Spinal IFN-γ-induced protein-10 (CXCL10) mediates metastatic breast cancer-induced bone pain by activation of microglia in rat models.Breast cancer research and treatment, 143(2), 255–263. https://doi.org/10.1007/s10549-013-2807-4
    38. Zhao, T., Zhang, X., Zeng, L., Xia, S., Hinton, A. O., Jr, & Li, X. (2014). Applications for radio-frequency identification technology in the perioperative setting.AORN journal, 99(6), 764–781. https://doi.org/10.1016/j.aorn.2013.07.022
    39. Ke, C., Li, C., Huang, X., Cao, F., Shi, D., He, W., Bu, H., Gao, F., Cai, T., Hinton, A. O., Jr, & Tian, Y. (2013). Protocadherin20 promotes excitatory synaptogenesis in dorsal horn and contributes to bone cancer pain.Neuropharmacology, 75, 181–190. https://doi.org/10.1016/j.neuropharm.2013.07.010