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Principal Investigator
Hassane S. Mchaourab
Louise B. McGavock Chair, Department of of Molecular Physiology and Biophysics Professor, Department of Physics Professor, Department Chemistry Professor, Center for Structural Biology ,
Research Staff
Qingyu Tang
Research Assistant Professor, Molecular Physiology and Biophysics
Investigating the structures and structural dynamics of ABC transporters to illuminate mechanistic principles for families of ABC transporters, which are implicated in the phenomenon of drug resistance and basic bacterial defense strategies that can be exploited to develop therapeutics.
Richard A. Stein
Research Associate Professor, Molecular Physiology and Biophysics
My interests are in using the tools or EPR spectroscopy to investigate protein dynamics. My expertise are in data analysis. Specifically, I develop and apply methods for fitting of DEER data.
Postdoctoral Fellows
Angshu Dutta
Post-doctoral Researcher, Molecular Physiology and Biophysics
I am interested in investigating the structural and functional characteristics of membrane proteins in order to understand their conformational landscape and mechanistic properties. This involves the utilization of various biophysical and biochemical techniques such as Cryo-Electron Microscopy (Cryo-EM), Electron Paramagnetic Resonance (EPR) spectroscopy etc.
Te-Yu Kao
Post-doctoral Researcher, Chemistry
My research focuses on deploying deep learning methods to enhance DEER spectroscopy and on unraveling the dynamics of intrinsically disordered proteins through DEER experiments. Co-advised with Dr. Jens Meiler.
Rahul M. Nair
Post-doctoral Researcher, Molecular Physiology and Biophysics
I am keen to explore the structural and functional properties of membrane proteins, with a focus on their conformational dynamics. To achieve this, I plan to utilize a combination of advanced techniques, including Electron Paramagnetic Resonance (EPR) spectroscopy, Cryo-Electron Microscopy (Cryo-EM), along with other biophysical and biochemical methods.
Graduate Students
Andy Ma
Graduate Student, Chemical and Physical Biology
My research focuses on deep learning and protein dynamics, where I develop and apply computational methods to understand how proteins move and function.
Sarah Zelle
Graduate Student, Chemical and Physical Biology Program
Proteome analysis of zebrafish models of cataractogenesis to determine proteostatic mechanisms in the ocular lens. Co-advised with Dr. Kevin Schey.
Alexandra C. Schwartz
Graduate Student, Chemical and Physical Biology Program
Evaluates members of the neurotransmitter:sodium symporter family (LeuT, MhsT, hSERT) using integrated DEER and AlphaFold2 methods.
Collaborators
Derek P. Claxton
Assistant Professor, Molecular Physiology and Biophysics
Role of membrane protein structure and dynamics in facilitating ion-coupled transport of substrates critical for multidrug resistance, and modulation of protein dynamics via lipid and drug interactions.
I graduated from the University of Alabama in Huntsville in 2004 with a BS in Chemistry and focus in biochemistry and biophysics. I completed my PhD in the Department of Molecular Physiology and Biophysics under the guidance of Dr. Mchaourab in 2010 applying methods in EPR spectroscopy to study the structural dynamics of the leucine transporter, a prokaryotic homolog of neurotransmitter transporters. Following a postdoctoral fellowship in the Gouaux laboratory at the Vollum Institute (Portland, OR) studying the structure and function of eukaryotic ion channels, I returned to the Mchaourab laboratory to pursue studies of ion-coupled substrate transporters involved in sugar metabolism and multidrug resistance.
Currently, I am a tenure track assistant professor in the department of molecular physiology and biophysics. Please visit my lab page
Eric Gouaux
Senior Scientist, Vollum Institute (Portland, OR), Investigator, Howard Hughes Medical Institute Jennifer and Bernard Lacroute Term Chair in Neuroscience Research, Oregon Health and Science University
https://www.ohsu.edu/xd/research/centers-institutes/vollum/faculty/gouauxlab.cfm
