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Principal Investigator

Hassane S. Mchaourab

Louise B. McGavock Chair, Department of of Molecular Physiology and Biophysics Professor, Department of Physics Professor, Department Chemistry Professor, Center for Structural Biology ,

I was born in Beirut, Lebanon and attended the American University of Beirut where I majored in Physics and pursued a Master’s degree although I did not complete it due to the civil war. I completed my Ph.D. in Biophysics at the medical College of Wisconsin under the supervision of James S. Hyde focusing on the development of the theory and instrumentation of EPR spectroscopy. For postdoctoral training, I joined the laboratory of Wayne L. Hubbell at the Jules Stein Eye Institute, UCLA where I applied EPR spectroscopy to understanding protein dynamics. Protein dynamics is the theme of my research program since I started in 1997. A more detailed description is found under the research menu.


Research Staff

Smriti Mishra

Research Instructor, Molecular Physiology and Biophysics Laboratory Manager, Molecular Physiology and Biophysics

Understanding the structure, function and dynamics of membrane multidrug transporters using spectroscopic and biophysical techniques.

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Richard Stein

Research Instructor, Molecular Physiology and Biophysics


Simon Wu

Research Instructor, Molecular Physiology and Biophysics

Roles of molecular chaperones, particularly sHSPs, in CNS development and diseases (Chaperonopathies); Protein aggregation and proteostatic neuropathology; Zebrafish embryology and genetics; Evolution and development


 


Post-Doctoral Fellows

Reza Dastvan

, Molecular Physiology and Biophysics

Multidrug transporters involved in the emergence of resistance in the treatment of bacterial infections and cancer.


 


Dungeng Peng

, Molecular Physiology and Biophysics

Protein dynamics of membrane proteins and transporters.


 


Graduate Students

Mark Vincent C. dela Cerna

Graduate Student, Chemical and Physical Biology Trainee, Molecular Biophysics Training Program Co-Vice President for Social Affairs, Chemical and Physical Biology Graduate Student Association

Mechanism of transport and biochemistry of a polypeptide-processing and secretion ABC transporter.


 


Alexandra W. Fuller

Graduate Student, Molecular Physiology and Biophysics Trainee, Vanderbilt Program in Molecular Medicine


Kevin L. Jagessar

Graduate Student, Chemical and Physical Biology Co-Vice President for Social Affairs, Chemical and Physical Biology Graduate Student Association

Mechanism of transport and biochemistry of multidrug and toxic compound extrusion (MATE) family of transporters.

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Sanjay Mishra

Graduate Student, Chemical and Physical Biology Vice-President for Academic Affairs, Chemical and Physical Biology Graduate Student Association

Characterization of small heat shock proteins (sHSPs), particularly lens crystallins, to understand their role in protein aggregation disorders, stress response, and ageing.

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Francisco G. Rodriguez

Graduate Student, Chemistry

Studying the dynamics of CamKII using EPR and NMR.


 


Collaborators

Eric Gouaux

Senior Scientist, Vollum Institute (Portland, OR) Investigator, Howard Hughes Medical Institute Jennifer and Bernard Lacroute Term Chair in Neuroscience Research, Oregon Health and Science University

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Jens Meiler

Professor, Department of Chemistry, Vanderbilt University

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