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Principal Investigator

Hassane S. Mchaourab

Louise B. McGavock Chair, Department of of Molecular Physiology and Biophysics Professor, Department of Physics Professor, Department Chemistry Professor, Center for Structural Biology ,


Research Staff

Richard Stein

Research Assistant Professor, Molecular Physiology and Biophysics

My interests are in using the tools or EPR spectroscopy to investigate protein dynamics. My expertise are in data analysis. Specifically, I develop and apply methods for fitting of DEER data.


Derek P. Claxton

Research Assistant Professor, Molecular Physiology and Biophysics

Role of membrane protein structure and dynamics in facilitating ion-coupled transport of substrates critical for multidrug resistance, and modulation of protein dynamics via lipid and drug interactions.


Patrick S. Page-McCaw

Research Assistant Professor, Molecular Physiology and Biophysics

Genetic, molecular, and biochemical characterization of small heat shock protein function in cardiovascular physiology and vision.


Brinda Selvaraj

Program Manager, Molecular Basis of Genetic Diseases. Research Instructor, Molecular Physiology and Biophysics

The program of Molecular Basis of Genetic Diseases focuses towards the fundamental understanding of how mutations & variants modulate protein functions by altering their structure, function, physical associations, energy landscapes etc and thereby helping to mechanistically underpin the phenotype.

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Post-Doctoral Fellows

Jinhee Park

Post-doctoral Researcher, Molecular Physiology and Biophysics

Investigating the role of small heat shock proteins in stress using the zebrafish model.


Kevin L. Jagessar

Post-doctoral Researcher, Molecular Physiology and Biophysics

Mechanism of transport and biochemistry of multidrug and toxic compound extrusion (MATE) family of transporters.

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Qingyu Tang

Post-doctoral Researcher, Molecular Physiology and Biophysics

Investigating the structures and structural dynamics of ABC transporters to illuminate mechanistic principles for families of ABC transporters, which are implicated in the phenomenon of drug resistance and basic bacterial defense strategies that can be exploited to develop therapeutics.


Rahul M.Nair

Post-doctoral Researcher, Molecular Physiology and Biophysics

My interest lies in understanding the structure, function and dynamics of MFS transporters with a particular focus on substrate and drug binding


Ruojing Zhang

Post-doctoral Researcher, Molecular Physiology and Biophysics

My research project will be the mechanism and dynamics investigation of P-glycoprotein and the molecular dynamic studies of MsbA


Research Assistants

Michael J Mohan

Research Assistant, Molecular Physiology and Biophysics

Working on membrane protein expression and purification, making and maintaining lab’s communal stocks and assisting in lab’s general maintenance


Graduate Students

Diego del Alamo

Graduate Student, Chemical and Physical Biology Program

Spectroscopic characterization and computational modeling of transporter proteins (co-advised with Dr. Jens Meiler)


Alexandra Schwartz

Graduate Student, Chemical and Physical Biology Program

In this lab, I plan to study protein dynamics using molecular dynamic simulations and pulse EPR technique, double electron-electron resonance (DEER). In my initial studies, I am evaluating the structure of Leu-T, a bacterial homolog to many transporters of interest. In particular, I hope to elucidate mechanisms of the serotonin and dopamine transporters that could be targeted for novel drugs in the treatment of autism, depression, and Parkinson’s.


Sarah Zelle

Graduate Student, Chemical and Physical Biology Program

Proteome analysis of zebrafish models of cataractogenesis to determine proteostatic mechanisms in the ocular lens. Co-advised with Dr. Kevin Schey.


Collaborators

Richard O’Brien

Professor, Department of Molecular Physiology & Biophysics

Richard O’Brien Lab


Eric Gouaux

Senior Scientist, Vollum Institute (Portland, OR), Investigator, Howard Hughes Medical Institute Jennifer and Bernard Lacroute Term Chair in Neuroscience Research, Oregon Health and Science University

https://www.ohsu.edu/xd/research/centers-institutes/vollum/faculty/gouauxlab.cfm


Jens Meiler

Professor, Department of Chemistry, Vanderbilt University

http://www.meilerlab.org/


Osamu Nureki

Professor, Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Japan

http://www.nurekilab.net/index.php/en?FrontPage