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Hasty Laboratory

Hasty Laboratory Publications

2024

Burak M. Furkan , Stanley Takara L. , Lawson Elizabeth A. , Campbell Sophia L. , Lynch Lydia , Hasty Alyssa H. , Ana I. Ana I. , Dixit Vishwa D. , Hotamışlıgil Gökhan S. , Sheedy Frederick J. , Dixon Anne E. , Brinkley Tina E. , Hill Joseph A. , Donath Marc Y. , Grinspoon Steven K. , Adiposity, immunity, and inflammation: interrelationships in health and disease: A report from 24th annual Harvard nutrition obesity symposium, June 2023 2024 Apr 29;
Winn C , Schleh W , Garcia N , Lantier Louise , McGuinness P , Blair A , Hasty H , Wasserman H , Insulin at the Intersection of Thermoregulation and Glucose Homeostasis Molecular Metabolism. 2024 Feb 12;

2023

Robertson Katrina , Schleh Michael , Harrison Fiona , Hasty Alyssa , Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner Brain Behavior Immunity. 2023 Dec 21;
Caslin L , Bolus Reid , Thomas Christopher , Toki Shinji , Norlander E , Peebles Stokes , Hasty H , Bovine Serum Albumin Elicits IL-33-Dependent Adipose Tissue Eosinophilia: Potential Relevance to Ovalbumin-induced Models of Allergic Disease Immunohorizons. 2023 Dec ;
Schleh W , Caslin L , Garcia N , Mashayekhi Mona , Srivastava Gitanjali , Bradley B , Hasty H , Metaflammation in obesity and its therapeutic targeting Science Translational Medicine. 2023 Nov 22; 15 (723). adf9382
Winn C , Patel S , Blair A , Rodriguez Alec , Garcia N , Yang S , Hasty H , Deletion of complement factor 5 amplifies glucose intolerance in obese male but not female mice. Am J Physiol Endocrinol Metab .. 2023 ;
Caslin L , Cottam A , Pinon M , Boney Y , Hasty H , Weight cycling induces innate immune memory in adipose tissue macrophages Frontiers in Immunology. 2023 ;

2022

Winn C , Wolf M , Garcia N , Hasty H , Exon 2-mediated deletion of Trem2 does not worsen metabolic function in diet-induced obese mice 2022 ;
Garcia N , Wanjalla N , Mashayekhi Mona , Hasty H , Immune Cell Activation in Obesity and Cardiovascular Disease Curr Hypertens Rep . 2022 ;
Wolf M , Fingleton Barbara , Hasty H , The therapeutic potential of TREM2 in cancer Front Oncol . . 2022 ;
Ameka Magdalena K , Beavers William N , Shaver Ciara M , Ware Lorraine B , Kerchberger Vern Eric , Schoenfelt Kelly Q , Sun Lili , Koyama Tatsuki , Skaar Eric P , Becker Lev , Hasty Alyssa H , An Iron Refractory Phenotype in Obese Adipose Tissue Macrophages Leads to Adipocyte Iron Overload 2022 Jul 3;
Winn Nathan C , Cottam Matthew A , Bhanot Monica , Caslin Heather L , Garcia Jamie N , Drigo Rafael Arrojo E , Hasty Alyssa H , Weight Cycling Impairs Pancreatic Insulin Secretion but Does Not Perturb Whole-Body Insulin Action in Diet-Induced Obese Mice 2022 Jul 8;
Ameka Magdalena , Hasty Alyssa H , Paying the Iron Price: Liver Iron Homeostasis and Metabolic Disease 2022 Jun 29;
Cottam Matthew , Caslin Heather , Winn Nathan , Hasty Alyssa , Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice 2022 May 26;

2021

Winn Nathan C , Cottam Matthew A , Wasserman David H , Hasty Alyssa H , Exercise and Adipose Tissue Immunity: Outrunning Inflammation 2021 May 29;
Winn Nathan , Wolf Elyssa , Cottam Matthew , Bhanot Monica , Hasty Alyssa , Myeloid-specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice 2021 Sep 1;

2020

Ameka Magdalene , Hasty Alyssa , Fat and Iron Don’t Mix 2020 Oct 8;
Breuer A , Pacheco C , Washington K , Montgomery A , Hasty H , Kennedy J , CD8+ T Cells regulate liver injury in obesity-related nonalcoholic fatty liver disease 2020 Feb 1;
Rogers M. , Serezani H. , Eastman J. , Hasty H. , Englund-Ögge Linda , Jacobsson Bo , Vickers C. , Aronoff M. , Palmitate induces apoptotic cell death and inflammasome activation in human placental macrophages 2020 Jan 15;
Caslin L , Bhanot Monica , Bolus Reid , Hasty H , Adipose Tissue Macrophages: Unique Polarization and Bioenergetics in Obesity 2020 May 1;
Winn N.C. , Volk K.M. , Hasty A.H. , Regulation of tissue iron homeostasis: the macrophage “ferrostat” JCI Insight. 2020 Jan 30; 2 (5).

2019

Peterson K. R. , Gutierrez D. A. , Kikuchi T. , Anderson-Baucum E. K. , Winn N. C. , Shuey M. M. , Bolus W. R. , McGuinness O. P. , Hasty A. H. , Impaired insulin signaling in the B10.D2-Hc0 H2d H2-T18c/oSnJ mouse model of complement factor 5 (C5) deficiency American Journal of Physiology Endocrinology and Metabolism. 2019 May 14;
Caslin H. L. , Hasty A. H. , Extrinsic and Intrinsic Immunometabolism Converge: Perspectives on Future Research and Therapeutic Development for Obesity Current Obesity Reports. 2019 Mar 27;

2018

Bolus WRB , Kennedy AJK , Hasty AHH , Obesity-induced reduction of adipose eosinophils is reversed with low-calorie dietary intervention Physiological Reports. 2018 Nov ; 6 (22). e13919
Bolus WRB , Diversity of Adipose Tissue Immune Cells: Are All Eosinophils Created Equal? Bioessays. 2018 Sep 14;
Bolus WRB , Hasty AH , Contributions of Innate type 2 Inflammation to Adipose Function Journal of Lipid Research. 2018 Jun 11;
Cottam MA , Itani HA , Beasley AA , Hasty AH , Links between Immunologic Memory and Metabolic Cycling Journal of Immunology. 2018 Jun 1; 200 (11). 3681-3689
Hubler MJ , Erikson KM , Kennedy AJ , Hasty AH , MFehi adipose tissue macrophages compensate for tissue iron perturbations in mice American Journal of Physiology Cell Physiology. 2018 May 16;
Peterson KR , Cottam MA , Kennedy AJ , Hasty AH , , Macrophage-Targeted Therapeutics for Metabolic Disease Trends in Pharmacological Sciences. 2018 Apr 4; 39 (6). 536-547

2017

Peterson KR , Flaherty DK , Hasty AH , Obesity Alters B Cell and Macrophage Populations in Brown Adipose Tissue. Obesity (Silver Spring, Md.). 2017 Nov ; 25 (11). 1881-1884
Bolus WR , Peterson KR , Hubler MJ , Kennedy AJ , Gruen ML , Hasty AH , Elevating adipose eosinophils in obese mice to physiologically normal levels does not rescue metabol… Molecular metabolism. 2017 Dec 16;

2016

Orr JS , Kennedy AJ , Hill AA , Anderson-Baucum EK , Hubler MJ , Hasty AH , CC-chemokine receptor 7 (CCR7) deficiency alters adipose tissue leukocyte populations in mice. Physiological reports. 2016 Sep ; 4 (18).
Ong HH , Webb CD , Gruen ML , Hasty AH , Gore JC , Welch EB , Fat-water MRI of a diet-induced obesity mouse model at 15.2T. Journal of medical imaging (Bellingham, Wash.). 2016 Apr ; 3 (2). 026002

2015

Bolus WR , Gutierrez DA , Kennedy AJ , Anderson-Baucum EK , Hasty AH , CCR2 deficiency leads to increased eosinophils, alternative macrophage activation, and type 2 cytoki… Journal of leukocyte biology. 2015 May 1;
Riley KG , Pasek RC , Maulis MF , Dunn JC , Bolus WR , Kendall PL , Hasty AH , Gannon M , Macrophages are essential for CTGF-mediated adult β-cell proliferation after injury. Molecular Metabolism. 2015 May 19;
Hill AH , Anderson-Baucum EK , Kennedy AJ , Webb CD , Yull FE , Hasty AH , Activation of NF-κB drives the enhanced survival of adipose tissue macrophages in an obesogenic env… Molecular Metabolism. 2015 Jul ;
Hubler MJ , Peterson KR , Hasty AH , Iron homeostasis: a new job for macrophages in adipose tissue? Trends in endocrinology and metabolism: TEM. 2015 Jan 16;

2014

Hill AA , Bolus WR , Hasty AH , A decade of progress in adipose tissue macrophage biology. Immunological reviews. 2014 Nov ; 262 (1). 134-52
Anderson-Baucum EK , Major AS , Hasty AH , A possible secondary immune response in adipose tissue during weight cycling: The ups and downs of y… Adipocyte. 2014 Apr 1; 3 (2). 141-5
Hasty AH , Gutierrez DA , What have we really learned about macrophage recruitment to adipose tissue? Endocrinology. 2014 Jan ; 155 (1). 12-4
Orr JS , Kennedy A , Anderson-Baucum EK , Webb CD , Fordahl SC , Erikson KM , Zhang Y , Etzerodt A , Moestrup SK , Hasty AH , Obesity alters adipose tissue macrophage iron content and tissue iron distribution. Diabetes. 2014 Feb ; 63 (2). 421-32
Buckman LB , Hasty AH , Flaherty DK , Buckman CT , Thompson MM , Matlock BK , Weller K , Ellacott KL , Obesity induced by a high-fat diet is associated with increased immune cell entry into the central n… Brain, behavior, and immunity. 2014 Jan ; 35 33-42

2013

Hasty AH , Yvan-Charvet L , Liver X receptor α-dependent iron handling in M2 macrophages: The missing link between cholesterol … Circulation research. 2013 Nov 8; 113 (11). 1182-5
Kennedy A , Webb CD , Hill AA , Gruen ML , Jackson LG , Hasty AH , Loss of CCR5 results in glucose intolerance in diet-induced obese mice. American journal of physiology. Endocrinology and metabolism. 2013 Oct 1; 305 (7). E897-906
Anderson EK , Gutierrez DA , Kennedy A , Hasty AH , Weight cycling increases T-cell accumulation in adipose tissue and impairs systemic glucose toleranc… Diabetes. 2013 Sep ; 62 (9). 3180-8
Orr JS , Kennedy AJ , Hasty AH , Isolation of adipose tissue immune cells. Journal of visualized experiments : JoVE. 2013 ; (75). e50707
Kang L , Lantier L , Kennedy A , Bonner JS , Mayes WH , Bracy DP , Bookbinder LH , Hasty AH , Thompson CB , Wasserman DH , Hyaluronan accumulates with high-fat feeding and contributes to insulin resistance. Diabetes. 2013 Jun ; 62 (6). 1888-96

2012

Hasty AH , Harrison DG , Endoplasmic reticulum stress and hypertension – a new paradigm? The Journal of clinical investigation. 2012 Nov 1; 122 (11). 3859-61
Orr JS , Puglisi MJ , Ellacott KL , Lumeng CN , Wasserman DH , Hasty AH , Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages. Diabetes. 2012 Nov ; 61 (11). 2718-27
Anderson EK , Hill AA , Hasty AH , Stearic acid accumulation in macrophages induces toll-like receptor 4/2-independent inflammation lea… Arteriosclerosis, thrombosis, and vascular biology. 2012 Jul ; 32 (7). 1687-95
Kennedy A , Gruen ML , Gutierrez DA , Surmi BK , Orr JS , Webb CD , Hasty AH , Impact of macrophage inflammatory protein-1α deficiency on atherosclerotic lesion formation, hepati… PloS one. 2012 ; 7 (2). e31508
Gutierrez DA , Hasty AH , Haematopoietic leptin receptor deficiency does not affect macrophage accumulation in adipose tissue … The Journal of endocrinology. 2012 Mar ; 212 (3). 343-51

2011

Gutierrez DA , Kennedy A , Orr JS , Anderson EK , Webb CD , Gerrald WK , Hasty AH , Aberrant accumulation of undifferentiated myeloid cells in the adipose tissue of CCR2-deficient mice… Diabetes. 2011 Nov ; 60 (11). 2820-9
Puglisi MJ , Hasty AH , Saraswathi V , The role of adipose tissue in mediating the beneficial effects of dietary fish oil. The Journal of nutritional biochemistry. 2011 Feb ; 22 (2). 101-8

2010

Surmi BK , Webb CD , Ristau AC , Hasty AH , Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipo… American journal of physiology. Endocrinology and metabolism. 2010 Sep ; 299 (3). E437-45
Rudolph TK , Rudolph V , Edreira MM , Cole MP , Bonacci G , Schopfer FJ , Woodcock SR , Franek A , Pekarova M , Khoo NK , Hasty AH , Baldus S , Freeman BA , Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2010 May ; 30 (5). 938-45
Kennedy AJ , Ellacott KL , King VL , Hasty AH , Mouse models of the metabolic syndrome. Disease models & mechanisms. 2010 ; 3 (3-4). 156-66
Rudolph TK , Rudolph V , Edreira MM , Cole MP , Bonacci G , Schopfer FJ , Woodcock SR , Franek A , Pekarova M , Khoo NK , Hasty AH , Baldus S , Freeman BA , Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2010 May ; 30 (5). 938-45
Surmi BK , Webb CD , Ristau AC , Hasty AH , Absence of macrophage inflammatory protein-1{alpha} does not impact macrophage accumulation in adipo… American journal of physiology. Endocrinology and metabolism. 2010 Sep ; 299 (3). E437-45
Anderson EK , Gutierrez DA , Hasty AH , Adipose tissue recruitment of leukocytes. Current opinion in lipidology. 2010 Jun ; 21 (3). 172-7

2009

Saraswathi V , Morrow JD , Hasty AH , Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-… The Journal of nutrition. 2009 Dec ; 139 (12). 2380-6
Li S , Sun Y , Liang CP , Thorp EB , Han S , Jehle AW , Saraswathi V , Pridgen B , Kanter JE , Li R , Welch CL , Hasty AH , Bornfeldt KE , Breslow JL , Tabas I , Tall AR , Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice an… Circulation research. 2009 Nov 20; 105 (11). 1072-82
Saraswathi V , Morrow JD , Hasty AH , Dietary fish oil exerts hypolipidemic effects in lean and insulin sensitizing effects in obese LDLR-… The Journal of nutrition. 2009 Dec ; 139 (12). 2380-6
Li S , Sun Y , Liang CP , Thorp EB , Han S , Jehle AW , Saraswathi V , Pridgen B , Kanter JE , Li R , Welch CL , Hasty AH , Bornfeldt KE , Breslow JL , Tabas I , Tall AR , Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice an… Circulation research. 2009 Nov 20; 105 (11). 1072-82
Saraswathi V , Hasty AH , Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity … Arteriosclerosis, thrombosis, and vascular biology. 2009 Nov ; 29 (11). 1937-43
Romero-Aleshire MJ , Diamond-Stanic MK , Hasty AH , Hoyer PB , Brooks HL , Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid… American journal of physiology. Regulatory, integrative and comparative physiology. 2009 Sep ; 297 (3). R587-92
Gutierrez DA , Puglisi MJ , Hasty AH , Impact of increased adipose tissue mass on inflammation, insulin resistance, and dyslipidemia. Current diabetes reports. 2009 Feb ; 9 (1). 26-32
Coenen KR , Gruen ML , Lee-Young RS , Puglisi MJ , Wasserman DH , Hasty AH , Impact of macrophage toll-like receptor 4 deficiency on macrophage infiltration into adipose tissue … Diabetologia. 2009 Feb ; 52 (2). 318-28
Batoy SM , Borgmann S , Flick K , Griffith J , Jones JJ , Saraswathi V , Hasty AH , Kaiser P , Wilkins CL , Lipid and phospholipid profiling of biological samples using MALDI Fourier transform mass spectromet… Lipids. 2009 Apr ; 44 (4). 367-71

2008

Surmi BK , Hasty AH , Macrophage infiltration into adipose tissue: initiation, propagation and remodeling. Future lipidology. 2008 ; 3 (5). 545-556
Kato T , Shimano H , Yamamoto T , Ishikawa M , Kumadaki S , Matsuzaka T , Nakagawa Y , Yahagi N , Nakakuki M , Hasty AH , Takeuchi Y , Kobayashi K , Takahashi A , Yatoh S , Suzuki H , Sone H , Yamada N , Palmitate impairs and eicosapentaenoate restores insulin secretion through regulation of SREBP-1c in… Diabetes. 2008 Sep ; 57 (9). 2382-92
Inoue N , Yahagi N , Yamamoto T , Ishikawa M , Watanabe K , Matsuzaka T , Nakagawa Y , Takeuchi Y , Kobayashi K , Takahashi A , Suzuki H , Hasty AH , Toyoshima H , Yamada N , Shimano H , Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypert… The Journal of biological chemistry. 2008 Jul 25; 283 (30). 21220-9
Stafford JM , Yu F , Printz R , Hasty AH , Swift LL , Niswender KD , Central nervous system neuropeptide Y signaling modulates VLDL triglyceride secretion. Diabetes. 2008 Jun ; 57 (6). 1482-90
Plummer MR , Hasty AH , Atherosclerotic lesion formation and triglyceride storage in obese apolipoprotein AI-deficient mice. The Journal of nutritional biochemistry. 2008 Oct ; 19 (10). 664-73
Surmi BK , Atkinson RD , Gruen ML , Coenen KR , Hasty AH , The role of macrophage leptin receptor in aortic root lesion formation. American journal of physiology. Endocrinology and metabolism. 2008 Mar ; 294 (3). E488-95
Atkinson RD , Coenen KR , Plummer MR , Gruen ML , Hasty AH , Macrophage-derived apolipoprotein E ameliorates dyslipidemia and atherosclerosis in obese apolipopro… American journal of physiology. Endocrinology and metabolism. 2008 Feb ; 294 (2). E284-90

2007

Saraswathi V , Gao L , Morrow JD , Chait A , Niswender KD , Hasty AH , Fish oil increases cholesterol storage in white adipose tissue with concomitant decreases in inflamm… The Journal of nutrition. 2007 Jul ; 137 (7). 1776-82
Hao M , Head WS , Gunawardana SC , Hasty AH , Piston DW , Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfun… Diabetes. 2007 Sep ; 56 (9). 2328-38
Coenen KR , Hasty AH , Obesity potentiates development of fatty liver and insulin resistance, but not atherosclerosis, in h… American journal of physiology. Endocrinology and metabolism. 2007 Aug ; 293 (2). E492-9
Coenen KR , Gruen ML , Hasty AH , Obesity causes very low density lipoprotein clearance defects in low-density lipoprotein receptor-de… The Journal of nutritional biochemistry. 2007 Nov ; 18 (11). 727-35
Coenen KR , Gruen ML , Chait A , Hasty AH , Diet-induced increases in adiposity, but not plasma lipids, promote macrophage infiltration into whi… Diabetes. 2007 Mar ; 56 (3). 564-73
Hasty AH , Gruen ML , Terry ES , Surmi BK , Atkinson RD , Gao L , Morrow JD , Effects of vitamin E on oxidative stress and atherosclerosis in an obese hyperlipidemic mouse model. The Journal of nutritional biochemistry. 2007 Feb ; 18 (2). 127-33
Matsuzaka T , Shimano H , Yahagi N , Kato T , Atsumi A , Yamamoto T , Inoue N , Ishikawa M , Okada S , Ishigaki N , Iwasaki H , Iwasaki Y , Karasawa T , Kumadaki S , Matsui T , Sekiya M , Ohashi K , Hasty AH , Nakagawa Y , Takahashi A , Suzuki H , Yatoh S , Sone H , Toyoshima H , Osuga J , Yamada N , Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance. Nature medicine. 2007 Oct ; 13 (10). 1193-202
Nuotio-Antar AM , Hachey DL , Hasty AH , Carbenoxolone treatment attenuates symptoms of metabolic syndrome and atherogenesis in obese, hyperl… American journal of physiology. Endocrinology and metabolism. 2007 Dec ; 293 (6). E1517-28
Gruen ML , Hao M , Piston DW , Hasty AH , Leptin requires canonical migratory signaling pathways for induction of monocyte and macrophage chem… American journal of physiology. Cell physiology. 2007 Nov ; 293 (5). C1481-8

2006

Wang Y , Oeser JK , Yang C , Sarkar S , Hackl SI , Hasty AH , McGuinness OP , Paradee W , Hutton JC , Powell DR , O'Brien RM , Deletion of the gene encoding the ubiquitously expressed glucose-6-phosphatase catalytic subunit-rel… The Journal of biological chemistry. 2006 Dec 29; 281 (52). 39982-9
Kato T , Shimano H , Yamamoto T , Yokoo T , Endo Y , Ishikawa M , Matsuzaka T , Nakagawa Y , Kumadaki S , Yahagi N , Takahashi A , Sone H , Suzuki H , Toyoshima H , Hasty AH , Takahashi S , Gomi H , Izumi T , Yamada N , Granuphilin is activated by SREBP-1c and involved in impaired insulin secretion in diabetic mice. Cell metabolism. 2006 Aug ; 4 (2). 143-54
Saraswathi V , Hasty AH , The role of lipolysis in mediating the proinflammatory effects of very low density lipoproteins in m… Journal of lipid research. 2006 Jul ; 47 (7). 1406-15
Nuotio-Antar AM , Hasty AH , Kovacs WJ , Quantitation and cellular localization of 11beta-HSD1 expression in murine thymus. The Journal of steroid biochemistry and molecular biology. 2006 May ; 99 (2-3). 93-9
Braun NA , Mohler PJ , Weisgraber KH , Hasty AH , Linton MF , Yancey PG , Su YR , Fazio S , Swift LL , Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. Journal of lipid research. 2006 Jun ; 47 (6). 1176-86
Nakagawa Y , Shimano H , Yoshikawa T , Ide T , Tamura M , Furusawa M , Yamamoto T , Inoue N , Matsuzaka T , Takahashi A , Hasty AH , Suzuki H , Sone H , Toyoshima H , Yahagi N , Yamada N , TFE3 transcriptionally activates hepatic IRS-2, participates in insulin signaling and ameliorates di… Nature medicine. 2006 Jan ; 12 (1). 107-13
Liang X , Kanjanabuch T , Mao SL , Hao CM , Tang YW , Declerck PJ , Hasty AH , Wasserman DH , Fogo AB , Ma LJ , Plasminogen activator inhibitor-1 modulates adipocyte differentiation. American journal of physiology. Endocrinology and metabolism. 2006 Jan ; 290 (1). E103-E113
Gruen ML , Saraswathi V , Nuotio-Antar AM , Plummer MR , Coenen KR , Hasty AH , Plasma insulin levels predict atherosclerotic lesion burden in obese hyperlipidemic mice. Atherosclerosis. 2006 May ; 186 (1). 54-64

2005

Zhu MY , Hasty AH , Harris C , Linton MF , Fazio S , Swift LL , Physiological relevance of apolipoprotein E recycling: studies in primary mouse hepatocytes. Metabolism: clinical and experimental. 2005 Oct ; 54 (10). 1309-15
Gruen ML , Plummer MR , Zhang W , Posey KA , Linton MF , Fazio S , Hasty AH , Persistence of high density lipoprotein particles in obese mice lacking apolipoprotein A-I. Journal of lipid research. 2005 Sep ; 46 (9). 2007-14
Bodary PF , Gu S , Shen Y , Hasty AH , Buckler JM , Eitzman DT , Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2005 Aug ; 25 (8). e119-22
Su YR , Dove DE , Major AS , Hasty AH , Boone B , Linton MF , Fazio S , Reduced ABCA1-mediated cholesterol efflux and accelerated atherosclerosis in apolipoprotein E-defici… Circulation. 2005 May 10; 111 (18). 2373-81
Hasty AH , Plummer MR , Weisgraber KH , Linton MF , Fazio S , Swift LL , The recycling of apolipoprotein E in macrophages: influence of HDL and apolipoprotein A-I. Journal of lipid research. 2005 Jul ; 46 (7). 1433-9

2003

Yoshikawa T , Ide T , Shimano H , Yahagi N , Amemiya-Kudo M , Matsuzaka T , Yatoh S , Kitamine T , Okazaki H , Tamura Y , Sekiya M , Takahashi A , Hasty AH , Sato R , Sone H , Osuga J , Ishibashi S , Yamada N , Cross-talk between peroxisome proliferator-activated receptor (PPAR) alpha and liver X receptor (LXR… Molecular endocrinology (Baltimore, Md.). 2003 Jul ; 17 (7). 1240-54
Raffaï RL , Hasty AH , Wang Y , Mettler SE , Sanan DA , Linton MF , Fazio S , Weisgraber KH , Hepatocyte-derived ApoE is more effective than non-hepatocyte-derived ApoE in remnant lipoprotein cl… The Journal of biological chemistry. 2003 Mar 28; 278 (13). 11670-5
Farkas MH , Swift LL , Hasty AH , Linton MF , Fazio S , The recycling of apolipoprotein E in primary cultures of mouse hepatocytes. Evidence for a physiolog… The Journal of biological chemistry. 2003 Mar 14; 278 (11). 9412-7
Su YR , Ishiguro H , Major AS , Dove DE , Zhang W , Hasty AH , Babaev VR , Linton MF , Fazio S , Macrophage apolipoprotein A-I expression protects against atherosclerosis in ApoE-deficient mice and… Molecular therapy : the journal of the American Society of Gene Therapy. 2003 Oct ; 8 (4). 576-83

2002

Fazio S , Babaev VR , Burleigh ME , Major AS , Hasty AH , Linton MF , Physiological expression of macrophage apoE in the artery wall reduces atherosclerosis in severely h… Journal of lipid research. 2002 Oct ; 43 (10). 1602-9
Amemiya-Kudo M , Shimano H , Hasty AH , Yahagi N , Yoshikawa T , Matsuzaka T , Okazaki H , Tamura Y , Iizuka Y , Ohashi K , Osuga J , Harada K , Gotoda T , Sato R , Kimura S , Ishibashi S , Yamada N , Transcriptional activities of nuclear SREBP-1a, -1c, and -2 to different target promoters of lipogen… Journal of lipid research. 2002 Aug ; 43 (8). 1220-35
Matsuzaka T , Shimano H , Yahagi N , Yoshikawa T , Amemiya-Kudo M , Hasty AH , Okazaki H , Tamura Y , Iizuka Y , Ohashi K , Osuga J , Takahashi A , Yato S , Sone H , Ishibashi S , Yamada N , Cloning and characterization of a mammalian fatty acyl-CoA elongase as a lipogenic enzyme regulated … Journal of lipid research. 2002 Jun ; 43 (6). 911-20
Yahagi N , Shimano H , Hasty AH , Matsuzaka T , Ide T , Yoshikawa T , Amemiya-Kudo M , Tomita S , Okazaki H , Tamura Y , Iizuka Y , Ohashi K , Osuga J , Harada K , Gotoda T , Nagai R , Ishibashi S , Yamada N , Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not ob… The Journal of biological chemistry. 2002 May 31; 277 (22). 19353-7
Matsuzaka T , Shimano H , Yahagi N , Amemiya-Kudo M , Yoshikawa T , Hasty AH , Tamura Y , Osuga J , Okazaki H , Iizuka Y , Takahashi A , Sone H , Gotoda T , Ishibashi S , Yamada N , Dual regulation of mouse Delta(5)- and Delta(6)-desaturase gene expression by SREBP-1 and PPARalpha. Journal of lipid research. 2002 Jan ; 43 (1). 107-14

2001

Yoshida H , Hasty AH , Major AS , Ishiguro H , Su YR , Gleaves LA , Babaev VR , Linton MF , Fazio S , Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice. Circulation. 2001 Dec 4; 104 (23). 2820-5
Hasty AH , Shimano H , Osuga J , Namatame I , Takahashi A , Yahagi N , Perrey S , Iizuka Y , Tamura Y , Amemiya-Kudo M , Yoshikawa T , Okazaki H , Ohashi K , Harada K , Matsuzaka T , Sone H , Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin a… The Journal of biological chemistry. 2001 Oct 5; 276 (40). 37402-8
Yoshikawa T , Shimano H , Amemiya-Kudo M , Yahagi N , Hasty AH , Matsuzaka T , Okazaki H , Tamura Y , Iizuka Y , Ohashi K , Osuga J , Harada K , Gotoda T , Kimura S , Ishibashi S , Yamada N , Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory elem… Molecular and cellular biology. 2001 May ; 21 (9). 2991-3000

2000

Amemiya-Kudo M , Shimano H , Yoshikawa T , Yahagi N , Hasty AH , Okazaki H , Tamura Y , Shionoiri F , Iizuka Y , Ohashi K , Osuga J , Harada K , Gotoda T , Sato R , Kimura S , Ishibashi S , Yamada N , Promoter analysis of the mouse sterol regulatory element-binding protein-1c gene. The Journal of biological chemistry. 2000 Oct 6; 275 (40). 31078-85
Hasty AH , Shimano H , Yahagi N , Amemiya-Kudo M , Perrey S , Yoshikawa T , Osuga J , Okazaki H , Tamura Y , Iizuka Y , Shionoiri F , Ohashi K , Harada K , Gotoda T , Nagai R , Ishibashi S , Yamada N , Sterol regulatory element-binding protein-1 is regulated by glucose at the transcriptional level. The Journal of biological chemistry. 2000 Oct 6; 275 (40). 31069-77

1999

Shimano H , Yahagi N , Amemiya-Kudo M , Hasty AH , Osuga J , Tamura Y , Shionoiri F , Iizuka Y , Ohashi K , Harada K , Gotoda T , Ishibashi S , Yamada N , Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction … The Journal of biological chemistry. 1999 Dec 10; 274 (50). 35832-9
Hasty AH , Linton MF , Swift LL , Fazio S , Determination of the lower threshold of apolipoprotein E resulting in remnant lipoprotein clearance. Journal of lipid research. 1999 Aug ; 40 (8). 1529-38
Hasty AH , Linton MF , Brandt SJ , Babaev VR , Gleaves LA , Fazio S , Retroviral gene therapy in ApoE-deficient mice: ApoE expression in the artery wall reduces early foa… Circulation. 1999 May 18; 99 (19). 2571-6
Fazio S , Linton MF , Hasty AH , Swift LL , Recycling of apolipoprotein E in mouse liver. The Journal of biological chemistry. 1999 Mar 19; 274 (12). 8247-53
Yahagi N , Shimano H , Hasty AH , Amemiya-Kudo M , Okazaki H , Tamura Y , Iizuka Y , Shionoiri F , Ohashi K , Osuga J , Harada K , Gotoda T , Nagai R , Ishibashi S , Yamada N , A crucial role of sterol regulatory element-binding protein-1 in the regulation of lipogenic gene ex… The Journal of biological chemistry. 1999 Dec 10; 274 (50). 35840-4

1998

Linton MF , Hasty AH , Babaev VR , Fazio S , Hepatic apo E expression is required for remnant lipoprotein clearance in the absence of the low den… The Journal of clinical investigation. 1998 Apr 15; 101 (8). 1726-36

1997

Fazio S , Babaev VR , Murray AB , Hasty AH , Carter KJ , Gleaves LA , Atkinson JB , Linton MF , Increased atherosclerosis in mice reconstituted with apolipoprotein E null macrophages. Proceedings of the National Academy of Sciences of the United States of America. 1997 Apr 29; 94 (9). 4647-52
Fazio S , Hasty AH , Carter KJ , Murray AB , Price JO , Linton MF , Leukocyte low density lipoprotein receptor (LDL-R) does not contribute to LDL clearance in vivo: bon… Journal of lipid research. 1997 Feb ; 38 (2). 391-400

Kennedy AJ , Ellacott KL , King VL , Hasty AH , Mouse models of the metabolic syndrome. Disease models & mechanisms. ; 3 (3-4). 156-66
Surmi BK , Hasty AH , The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue. Vascular pharmacology. ; 52 (1-2). 27-36
Surmi BK , Hasty AH , The role of chemokines in recruitment of immune cells to the artery wall and adipose tissue. Vascular pharmacology. ; 52 (1-2). 27-36