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Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.


Li SSuzhao , Sun Y Yu , Liang CP Chien-Ping , Thorp EB Edward B , Han S Seongah , Jehle AW Andreas W , Saraswathi V Viswanathan , Pridgen B Brian , Kanter JE Jenny E , Li R Rong , Welch CL Carrie L , Hasty AH Alyssa H , Bornfeldt KE Karin E , Breslow JL Jan L , Tabas I Ira , Tall AR Alan R . Circulation research. 2009 11 20; 105(11). 1072-82


The complications of atherosclerosis are a major cause of death and disability in type 2 diabetes. Defective clearance of apoptotic cells by macrophages (efferocytosis) is thought to lead to increased necrotic core formation and inflammation in atherosclerotic lesions.