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Nitro-fatty acids reduce atherosclerosis in apolipoprotein E-deficient mice.


Rudolph TKTanja K , Rudolph V Volker , Edreira MM Martin M , Cole MP Marsha P , Bonacci G Gustavo , Schopfer FJ Francisco J , Woodcock SR Steven R , Franek A Andreas , Pekarova M Michaela , Khoo NK Nicholas K H , Hasty AH Alyssa H , Baldus S Stephan , Freeman BA Bruce A . Arteriosclerosis, thrombosis, and vascular biology. 2010 5 ; 30(5). 938-45


Inflammatory processes and foam cell formation are key determinants in the initiation and progression of atherosclerosis. Electrophilic nitro-fatty acids, byproducts of nitric oxide- and nitrite-dependent redox reactions of unsaturated fatty acids, exhibit antiinflammatory signaling actions in inflammatory and vascular cell model systems. The in vivo action of nitro-fatty acids in chronic inflammatory processes such as atherosclerosis remains to be elucidated.