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Inhibition of long-chain acyl coenzyme A synthetases during fatty acid loading induces lipotoxicity in macrophages.


Saraswathi VViswanathan , Hasty AH Alyssa H . Arteriosclerosis, thrombosis, and vascular biology. 2009 11 ; 29(11). 1937-43


Obesity is often associated with hypertriglyceridemia and elevated free fatty acids (FFAs), which are independent risk factors for cardiovascular disease and diabetes. Although impairment of cholesterol homeostasis is known to induce toxicity in macrophages, the consequence of altered fatty acid homeostasis is not clear.