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Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice.


Bodary PFPeter F , Gu S Shufang , Shen Y Yuechun , Hasty AH Alyssa H , Buckler JM Joshua M , Eitzman DT Daniel T . Arteriosclerosis, thrombosis, and vascular biology. 2005 8 ; 25(8). e119-22


The direct role of leptin in vascular disease remains controversial. The objective of this study was to examine the effects of leptin treatment on atherosclerosis and thrombosis in atherosclerotic-prone mice.