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Isoform-specific effects of apolipoprotein E on atherogenesis: gene transduction studies in mice.


Yoshida HH , Hasty AH A H , Major AS A S , Ishiguro H H , Su YR Y R , Gleaves LA L A , Babaev VR V R , Linton MF M F , Fazio S S . Circulation. 2001 12 4; 104(23). 2820-5


We recently used a bone marrow-based gene therapy approach to show that small amounts of retrovirus-derived human apolipoprotein E3 (apoE3) produced by macrophages are protective against early atherosclerosis in apoE-deficient mice.