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Direct effect of cholesterol on insulin secretion: a novel mechanism for pancreatic beta-cell dysfunction.


Hao MMingming , Head WS W Steven , Gunawardana SC Subhadra C , Hasty AH Alyssa H , Piston DW David W . Diabetes. 2007 9 ; 56(9). 2328-38


Type 2 diabetes is often accompanied by abnormal blood lipid and lipoprotein levels, but most studies on the link between hyperlipidemia and diabetes have focused on free fatty acids (FFAs). In this study, we examined the relationship between cholesterol and insulin secretion from pancreatic beta-cells that is independent of the effects of FFAs.