Ben Blakley Receives a 2024 Eastern Analytical Symposium Graduate Student Research Award!

6.02.2024

Great job Ben!

The McLean Research Group Members Present their Work at the 2024 ASMS Conference in Anaheim, CA

06.02.2024

The McLean Research Group members presented their research at the 72nd annual American Society for Mass Spectrometry (ASMS) Conference, which was held in Anaheim, CA:

Oral Presentation:

Nadjali Chung “Measurable Influences of the Electrospray Solvent on Small Molecule Collision Cross Sections in Ion Mobility: the Possible Role of Protomers”

Workshop Lightning Talk:

Kyle Lira “Compilation of a Polysorbate CCS Database from Drift Tube and Traveling Wave Structures for Lossless Ion Manipulations Ion Mobility Measurements”

Poster Presentations:

Jody C. May “An Ion Mobility Collision Cross Section Database in Support of the Periodic Table of Food Initiative”
Kimberly Fabijanczuk “Characterizing Simple Carbohydrates Using Drift Tube and Structures for Lossless Ion Manipulations Ion Mobility for Oligomer Packing and Isomeric Resolution”
David Koomen “Evaluating Ion Mobility (IM) and Multi Reflecting Time-of-Flight (MRT) Mass Spectrometry Platforms for Non-targeted LC-MS, LC-MS/MS and LC-IM-MS Exposomic Studies”
Allison Reardon “High Resolution Ion Mobility Incorporating Traveling Wave Structures for Lossless Ion Manipulation Unveils Hidden Lipid Features within Total Lipid Fractions”
Hawkins Shepard “High-Throughput Screening of Bioengineered Microorganisms Using a “Fast-Pass” Desorption Electrospray Ionization-Mass Spectrometry Imaging Workflow”
Ben Blakley “Evaluation of Chiral Selection Strategies with Ion Mobility-Mass Spectrometry for Differentiating Enantiomers of Drug and Drug-Like Compounds”
Kyle Lira “Compilation of a Polysorbate CCS Database from Drift Tube and Traveling Wave Structures for Lossless Ion Manipulations Ion Mobility Measurements”

Allison Reardon Receives an ASMS 2024 Conference Graduate Student Award!

3.22.2024

Great job Allison!

Welcome Kim, Emma and Siya to the Research Group!

01.01.2024

Ben Blakley presents his work at SERMACS 2023 in Durham, NC

10.27.2023

Ben’s talk is titled “Noncovalent mononuclear copper complexation for high-throughput chiral drug differentiation using ion mobility-mass spectrometry”

Nadjali Chung Receives a 2023 Merck Research Award!

8.12.2023

Nadjali also gave a talk at the 2023 Merck Research Award for Underrepresented Chemists of Color Symposium in Rahway, NJ titled “Ion Mobility-Mass Spectrometry-Based Approaches for Improved Small Molecule Identification”

We’re proud of you Nadjali!

The McLean Research Group Members Present their Work at the 2023 ASMS Conference in Houston, TX

06.04.2023

The McLean Research Group members presented their research at the 71st annual American Society for Mass Spectrometry (ASMS) Conference, which was held in Houston, TX:

Breakfast Seminar Presentation:

Allison Reardon “Enhanced Lipid Analysis using High-Resolution Ion Mobility (HRIM) Incorporating Structures for Lossless Ion Manipulation”

Poster Presentations:

David Koomen “Investigating the Lipidome of ATP10d Corrected Murine Models Using LC-IM-MS with High Resolution Ion Mobility”
Allison Reardon “Improved Separation of Lipid Extracts Using High Resolution Ion Mobility Incorporating Structures for Lossless Ion Manipulation in LC-HRIM-HRMS”
Hawkins Shepard “Analysis of Crown Ether-Alkali Metal Complexes Using Ion Mobility- Mass Spectrometry”
Ben Blakley “Noncovalent Copper Complexation to Differentiate Drug Enantiomers by Conventional and High-Resolution Ion Mobility-Mass Spectrometry”
Kyle Lira “Characterizing the Molecular Composition of Polysorbates by High Resolution Ion Mobility-Mass Spectrometry (HRIM-HRMS)”

David Koomen Receives an ASMS 2023 Conference Graduate Student Award!

3.03.2023

Great job David!

Congratulations to Dr. Emanuel Zlibut on a Successful Dissertation Defense!

02.22.2023

Dr. Zlibut’s dissertation is titled “Structural Mass Spectrometry Approaches for the Study of Complexed Small Molecules”.

We’re proud of you Emanuel!

Vanessa Allwardt et al. Receive a Highly Cited Paper Award for their Organ-on-a-Chip Review in Bioengineering:

10.12.2022

“Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption”

Vanessa Allwardt, Alexander J. Ainscough, Priyalakshmi Viswanathan, Stacy D. Sherrod, John A. McLean, Malcolm Haddrick, and Virginia Pensabene, Bioengineering 7(3), 112, 2020.

Group Members Present at the 2022 ISIMS Conference in Memphis, TN

07.24.2022

The McLean Research Group members presented their research at the 2022 International Conference on Ion Mobility Spectrometry in Memphis, TN:

Poster Presentations:

Madelyn James “Ion Mobility-Mass Spectrometry Structural Mapping of Discrete Mass Polyurethane Oligomers” – Outstanding Poster Award!
Kyle Lira “Exploring the Separation of Sulfate-Conjugated Anabolic-Androgenic Steroid Isomers by High Resolution Ion Mobility”
Ben Blakley “Exploring Enantiomer Separations by Ion Mobility using Noncovalent Copper Complexes”
Alex Toler “Evaluation of Parameters to Optimize the Sensitivity and Resolution of a SLIM-based Ion Mobility Spectrometer”

The McLean Research Group Members Present their Work at the 2022 ASMS Conference in Minneapolis, MN

06.04.2022

The McLean Research Group members presented their research at the 70th annual American Society for Mass Spectrometry (ASMS) Conference, which was held in Minneapolis, MN:

Oral Presentation:

David Koomen “Untargeted Metabolomics Strategy to Identify Unknown Phase II Anabolic Androgenic Steroids with Liquid Chromatography-Ion Mobility-Mass Spectrometry for Doping Control Workflows”

Poster Presentations:

Jody C. May “Implementation of Temperature Induced Protein Unfolding on a Drift Tube Ion Mobility-Mass Spectrometer”
Bailey Rose “Structural Characterization of Previously Unresolved Lipids with High Resolution Ion Mobility (HRIM) – Mass Spectrometry”
Emanuel Zlibut “Noncovalent Complexes of Artemisinin with α-, β-, and γ- Cyclodextrin Studied by Structural Mass Spectrometry Approaches”
Hawkins Shepard “Advancing High-Throughput Metabolic Phenotyping of Bioengineered Bacteria with Desorption Electrospray Ionization-Mass Spectrometry Imaging and Untargeted Molecular Analysis”
Allison Reardon “Separation of Various Isomer Systems via High Resolution Ion Mobility (HRIM) Mass Spectrometry Incorporating Structures for Lossless Ion Manipulation”
Robert Gottschalk “Development of an Active Humidity Control System for Desorption Electrospray Ionization-Mass Spectrometry Imaging Applications”
Jared Robinson “Cardiolipin and Ceramide Phosphoethanolamine Lipid Conformational Trend Analysis with High Resolution Ion Mobility (HRIM) – Mass Spectrometry”

Congratulations to Dr. Bailey S. Rose on a Successful Dissertation Defense!

03.23.2022

Dr. Rose’s dissertation is titled “Multidimensional Analyses for High Confidence Untargeted Molecular Annotation using Structurally Specific Ion Mobility-Mass Spectrometry”.

We’re proud of you Bailey!

Congratulations to Amelia Taylor and co-authors on their recent publication!

01.25.2022

“Targeted and Untargeted Mass Spectrometry Reveals the Impact of High-Fat Diet on Peripheral Amino Acid Regulation in a Mouse Model of Alzheimer’s Disease” AL Taylor, DE Davis, SG Codreanu, FE Harrison, SD Sherrod, JA McLean; Journal of Proteome Research 20(9), 4405-4414 (2021).

Amelia Taylor is an undergraduate researcher in the group and her first-author publication focuses on finding dysregulated metabolites in an Alzheimer’s mouse model.

Welcome Kyle, Ben, Alex and Madelyn to the Research Group!

01.01.2022

Prof. McLean elected as a Fellow of the National Academy of Inventors for 2021

12.08.2021

From the NAI press announcement:

“The NAI Fellows Program highlights academic inventors who have demonstrated a spirit of innovation in creating or facilitating outstanding inventions that have made a tangible impact on the quality of life, economic development, and the welfare of society. Election to NAI Fellow is the highest professional distinction accorded solely to academic inventors.”

The McLean Research Group Members Present their Research at the 2021 ASMS Conference in Philadelphia, PA

10.31.2021

The McLean Research Group members presented their research at the 2021 American Society for Mass Spectrometry (ASMS) Conference, which was held in-person in Philadelphia, PA:

Oral Presentations:

John A. McLean “Refining the Landscape of Lipidomics with High Resolution Ion Mobility (SLIM)-Mass Spectrometry”
Jody C. May “Intact Protein and Small Molecule Structure Elucidation Using Thermal and Collision-Induced Unfolding with Ion Mobility-Mass Spectrometry Analysis”

Poster Presentations:

Bailey Rose “Lipid Collision Cross Section Calibration Strategies for High Resolution SLIM-based Traveling Wave Ion Mobility Separations”
Emanuel Zlibut “Evaluation of Computational Strategies to Interpret Ion Mobility Measurements for Chemically-Diverse Analytes”
Nadjali Chung “Integrating Online Ozonolysis-IM-MS Workflows: Enhancing Conversion Efficiency”
Hawkins Shepard “Analysis of Monodisperse Polyurethane Oligomers Using Ion Mobility-Mass Spectrometry”
Allison Reardon “Improved Separation of Isomers from Total Lipid Fractions via High Resolution Ion Mobility (HRIM) Incorporating Structures for Lossless Ion Manipulation”
David Koomen “Analysis of Intact Sulfate and Glucuronide Conjugates of Phase II Anabolic Androgenic Steroids Using LC-Ion Mobility-MS”
Amelia Taylor “Mass Spectrometry Reveals Impact of High Fat Diet on Peripheral Amino Acid Regulation in a Mouse Model of Alzheimer’s Disease”
Jared Robinson “Analysis of Ceramide Phosphoethanolamine and Cardiolipin Lipids on a Prototype High Resolution Ion Mobility SLIM Instrument”

Congratulations to Dr. Berkley Ellis on a Successful Dissertation Defense

06.09.2021

Dr. Berkley Ellis’ dissertation (defended June 2021) is titled “Accelerating Natural Product Discovery and Synthetic Biology Workflows Using Multidimensional Molecular Phenotyping”.
Good work Berk!

Amelia Taylor and Sael Sohni Receive Undergraduate Research Awards

04.28.2021

Undergraduate researcher Amelia Taylor receives the Merck Index Award and the Outstanding Chemistry Research Award, and undergraduate researcher Sael Sohni receives the Department’s Analytical Chemistry Award. Congratulations!

Congratulations to Dr. Don Davis and Dr. Rachel Harris on Their Successful Dissertation Defense

03.23.2021

Dr. Don Davis’ dissertation (defended March 2021) is titled “Multidimensional Separations in Complex Biological Matrices Utilizing Chromatography, Ion Mobility, and Mass Spectrometry.”

Dr. Rachel Harris’ dissertation (defended March 2021) is titled “Analysis of Biopolymers Using Structurally Selective Analytical Techniques in Combination with Mass Spectrometry”.

Welcome Hawkins, David and Allison to the Research Group!

01.01.2021

John McLean Leads Arts and Science Grand Challenge Initiative

08.26.2020

Prof. McLean leads the recently launched Advancing Solutions to Climate and Ecological Needs and Discoveries (ASCEND) Initiative. It is one of six Grand Challenge Initiatives supported by the College of Arts and Science.

Read more…

Congratulations to Dr. James Poland and Dr. Jaqueline Picache for Successfully Defending Their Dissertation

08.24.2020

Dr. James Poland dissertation (defended February 2020) is titled “Method Development towards Probing the Gut Metabolome using Reverse Phase Liquid Chromatography-Ion Mobility-Mass Spectrometry.”

Dr. Jackie Picache’s dissertation (defended August 2020) is titled “Strategies for Improving Multiomic Metabolite Identifications Using Compound Libraries, Machine Learning, and Structural Mass Spectrometry”.