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182. NORMAN-SLE Collaboration, “The NORMAN Suspect List Exchange (NORMAN-SLE): facilitating European and worldwide collaboration on suspect screening in high resolution mass spectrometry”Environ. Sci. Eur. 34(1), 2022, 1-26.


181. Pino JC, Lubbock ALR, Harris LA, Gutierrez DB, Farrow MA, Muszynski N, Tsui T, Sherrod SD, Norris JL, McLean JA, Caprioli RM, Wikswo JP, Lopez CF, “Processes in DNA-damage response from a whole-cell multi-omics perspectives”iScience 25(11), 2022, 105341.


180. Tomlinson ID, May JC, Harris RA, Buck KM, Rosenthal SJ, McLean JA, Hercules DM, “Preparation and characterization of discrete mass polyether-based polyurethane oligomers” Polymer 254, 2022, 125069.


179. Cukier HN, Griswold AJ, Codreanu SG, Prince LM, Sherrod SD, McLean JA, Dykxhoorn DM, Ess KC, Hedera P, Bowman AB, Neely MD, “Genomic, transcriptomic, and metabolomic profiles of hiPSC-derived dopamine neurons from clinically discordant brothers with identical PRKN deletions” npj Parkinson’s Disease 8(1), 2022, 1-17.


178. Rose BS, May JC, Reardon AR, McLean JA, “Collision Cross-Section Calibration Strategy for Lipid Measurements in SLIM-Based High-Resolution Ion Mobility” J. Amer. Soc. Mass Spectrom. 33(7), 2022, 1229-1237.


177. Reardon AR, Leaptrot KL, Rose BS, May JC, McLean JA, Sherman M, “Resolving Lipid Isomers with Novel Ion Mobility Mass Spectrometry Methods” Lab Manager. 2022.


Journal Cover

176. Zlibut E., Leaptrot K.L., May J.C., McLean J.A., “Enantiomer Differentiation of Amino Acid Stereoisomers by Structural Mass Spectrometry Using Noncovalent Trinuclear Copper Complexes”, J. Amer. Soc. Mass Spectrom. 33(6), 2022, 996-1002. 


175. Rose BS, May JC, Picache JA, Codreanu SG, Sherrod SD, McLean JA, “Improving confidence in lipidomic annotations by incorporating empirical ion mobility regression analysis and chemical class prediction” Bioinformatics 38(10), 2022, 2872-2879.


174. May JC, McLean JA, DeBord D, Leaptrot K, Rose BS, Deng LL, Moser KLW, “Improving confidence in lipidomic annotations by incorporating empirical ion mobility regression analysis and chemical class prediction” Column 18(05), 2022, 23-27.


173. Norris AC, Yazlovitskaya E, Zhu L, Rose BS, Yu S, McLean JA, Stafford J, Graham TR, “ATP10A has a protective and sex‐specific role in lipid metabolism” FASEB Journal 36(S1), 2022.


172. Koomen DC, May JC, McLean JA, “Insights and Prospects for Ion Mobility-Mass Spectrometry in Clinical Chemistry” Expert Rev. Proteomic. 19(1), 2022, 17-31.


171. Ellis B.M., Babele, P.K., May, J.C., Johnson, C.H., Pfleger, B.F., Young, J.D., McLean, J.A., Accelerating Strain Phenotyping with Desorption Electrospray Ionization-Imaging Mass Spectrometry and Untargeted Analysis of Intact Microbial Colonies, Proc. Natl. Acad. Sci. U.S.A. 118(49), 2021, e2109633118.


170. McLean JA, May JC, Sherman M, “Resolving the Isomer Problem: Tackling Characterization Challenges” BioCompare. 2021.


Book Chapter

169. Zlibut E., Leaptrot K.L., May J.C., McLean J.A., Chapter 12: Ion Mobility Mass Spectrometry in Metabolomics Studies, Ion Mobility-Mass Spectrometry: Fundamentals and Applications (Royal Society of Chemistry), 2021, 307-335.


168. Taylor A.L., Davis Jr. D.E., Codreanu S.G., Harrison F.E., Sherrod S.D., McLean J.A., Targeted and Untargeted Mass Spectrometry Reveals the Impact of High-Fat Diet on Peripheral Amino Acid Regulation in a Mouse Model of Alzheimer’s Disease, J. Proteome Res. 2021, 20(9), 4405-4414.


167. Miller D.R., McClain E.S., Dodds J.N., Balinski A., May J.C., McLean J.A., Cliffel D.E., Chlorpyrifos Disrupts Acetylcholine Metabolism Across Model Blood-Brain Barrier, Front. Bioeng. Biotech. 2021, 9, 622175.


166. Davis Jr D.E., Leaptrot K.L., Koomen D.C., May J.C., de A Calcancanti G., Padilha M.C., Pereira H.M.G., McLean J.A., Multidimensional Separations of Intact Phase II Steroid Metabolites Utilizing LC–Ion Mobility–HRMS, Anal Chem 2021, 93(31), 10990-10998.


165. Mancini V., McKeegan P.J., Schrimpe-Rutledge A.C., Codreanu S.G., Sherrod S.D., McLean J.A., Picton H.M., Pensabene V., Probing morphological, genetic and metabolomic changes of in vitro embryo development in a microfluidic device, Biotechnol Progress 2021, e3194.


164. Mancini V., Schrimpe-Rutledge A., Codreanu S., Sherrod S.D., McLean J.A.M., Picton H.M., Pensabene V., Metabolomic analysis evidences that uterine epithelial cells enhance blastocyst development in a microfluidic device, Cells 2021, 10(5), 1194.


163. Bryant J.M., Malabanan M.M., Vanderloop B.H., Nichols C.M., Haratipour Z., Poon K.T., Sherrod S.D., McLean J.A.M., Blind R.D., The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor Steroidogenic Factor-1 (NR5A1), J. Lipid Res. 2021, 62, 100081.






162. May J.C., Leaptrot K.L., Rose B.S., Wormwood Moser K.L., Deng L., Maxon L., DeBord D., McLean J.A., Resolving Power and Collision Cross Section Measurement Accuracy of a Prototype High-Resolution Ion Mobility Platform Incorporating Structures for Lossless Ion Manipulation, J. Am. Soc. Mass Spectrom., 2021, 32 (4), 1126-1137.


161. Popay T.M., Wang J., Adams C.M., Howard G.C., Codreanu S.G., Sherrod S.D., McLean J.A., Thomas L.R., Lorey S.L., Machida Y.J., Weissmiller A.M., Eischen C.M., Liu Q., Tansey W.P., MYC regulates ribosome biogenesis and mitochondrial gene expression programs through its interaction with host cell factor-1, Elife, 2021, 10:e60191.


Book Chapter

160. Rose B.S., Leaptrot K.L., Harris R.A., May J.C., McLean J.A., High Confidence Shotgun Lipidomics Using Structurally Selective Ion Mobility-Mass Spectrometry, Methods Mol. Biol. (Clifton, NJ), 2021, 2306:11-37.


159. Davis Jr D.E., Sherrod S.D., Grant-Branum R.L., Colby J.M., McLean J.A., Targeted Strategy to Analyze Antiepileptic Drugs in Human Serum by LC-MS/MS and LC-Ion Mobility-MS, Anal. Chem. 2020, 92 (21), 14648-14656.


158. Paudel B.B., Lewis J.E., Hardeman K.N., Hayford C.E., Robbins C.J., Stauffer P.E., Codreanu S.G., Sherrod S.D., McLean J.A., Kemp M.L., Quaranta V., An Integrative Gene Expression and Mathematical Flux Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells, Cancer Research, 2020, 80 (20).


157. Kahn M.J., Codreanu S.G., Goyal S., Wages P.A., Gorti S.K.K., Pearson M.J., Uribe I., Sherrod S.D., McLean J.A., Porter N.A., Robinson R.A.S., Evaluating a targeted multiple reaction monitoring approach to global untargeted lipidomic analyses of human plasma, Rapid Comm Mass Spectrom, 2020, 34 (22), e8911.


156. Allwardt V., Ainscough A.J., Viswanathan P., Sherrod S.D., McLean J.A., Haddrick M., Pensabene V., Translational Roadmap for the Organs-on-a-Chip Industry toward Broad Adoption, Bioengineering, 2020, 7, 112.


155. Manzo T., Prentice B.M., Anderson K.G., Raman A., Schalck A., Codreanu S.G., Lauson C.B.N., Tiberti S., Raimondi A., Jones M.A., Reyzer M., Bates B.M., Spraggins J.M., Patterson N.H., McLean J.A., Rai K., Tacchetti C., Tucci S., Wargo J.A., Rodighiero S., Clise-Dwyer K., Sherrod S.D., Kim M., Navin N.E., Caprioli R.M., Greenberg P.D., Draetta G., Nezi L., Accumulation of long-chain fatty acids in the tumor microenvironment drives dysfunction in intrapancreatic CD8+ T cells, J Exp Med, 2020, 217 (8): e20191920.


154. Picache J.A., May J.C., McLean J.A., Chemical Class Prediction of Unknown Biomolecules Using Ion Mobility-Mass Spectrometry and Machine Learning: Supervised Inference of Feature Taxonomy from Ensemble Randomization, Anal Chem2020, 92, 10759-10767.


153. Poland J.C., Leaptrot K.L., Sherrod S.D., Flynn C.R., McLean J.A., Collision Cross Section Conformational Analyses of Bile Acids via Ion Mobility–Mass Spectrometry, J Am Soc Mass Spectrom2020, 31, 8, 1625-1631.


152. May J.C., Knochenmuss R., Fjeldsted J.C., McLean J.A., Resolution of Isomeric Mixtures in Ion Mobility Using a Combined Demultiplexing and Peak Deconvolution Technique, Anal Chem 2020, 92, 14, 9482-9492.


151. Pfalzer A.C., Wilcox J.M., Codreanu S.G., Totten M., Bichell T.J.V., Halbesma T., Umashanker P., Yang K.L., Parmalee N.L., Sherrod S.D., Erikson K.M., Harrison F.E., McLean J.A., Ashner M., Bowman A.B., Huntington’s disease genotype suppresses global manganese-responsive processes in pre-manifest and manifest YAC128 mice, Metallomics 2020, 12, 1118-1130.


150. Tainter C.J., Schley N.D., Harris C.M., Stec D.F., Song A.K., Balinski A., May J.C., McLean J.A., Reece K.S., Harris T.M. Algal Toxin Goniodomin A Binds Potassium Ion Selectively to Yield a Conformationally Altered Complex with Potential Biological Consequences, J Nat Prod 2020, 83 (4), 1069-1081.


149. Chambers S.A., Moore R.E., Craft K.M., Thomas H.C., Das R., Manning S.D., Codreanu S.G., Sherrod S.D., Aronoff D.M., McLean J.A., Gaddy J.A., Townsend S.D., A Solution to Antifolate Resistance in Group B Streptococcus: Untargeted Metabolomics Identifies Human Milk Oligosaccharide-Induced Perturbations That Result in Potentiation of Trimethoprim, mBio 2020, 11:2, e00076-20.


148. Picache J.A., May J.C., McLean J.A., Crowd-Sourced Chemistry: Considerations for Building a Standardized Database to Improve Omic Analyses, ACS Omega 2020, 5:2, 980-985.



Caprioli R., Wikswo J., McLean J., Skaar E., Norris J.L., Lacy D.B., Sherrod S., Pino J., Gutierrez D., Muszynski N.D., Farrow M. (2020) High-Throughput, Multi-Omics Approach to Determine and Validate De Novo Global Mechanisms of Action for Drugs and Toxins. U.S. Patent No. US10,607,721 B2.


147. Eberly A.R., Beebout C.J., Carmen Tong C.M., Van Horn G.T., Green H.D., Fitzgerald M.J., De S., Apple E.K., Schrimpe-Rutledge A.C., Codreanu S.G., Sherrod S.D., McLean J.A., Clayton D.B., Stratton C.W., Schmitz J.E., Hadjifrangiskou M., Defining a Molecular Signature for Uropathogenic versus Urocolonizing Escherichia coli: The Status of the Field and New Clinical Opportunities, J Mol Biol 2020, 432:4, 786-804.


Book Chapter

146. Morris C.B., Poland J.C., May J.C., McLean J.A. (2020) Fundamentals of Ion Mobility-Mass Spectrometry for the Analysis of Biomolecules. In: Paglia G., Astarita G. (eds) Ion Mobility-Mass Spectrometry. Methods in Molecular Biology, vol 2084. Humana, New York, NY.


145. Harris R.A., Picache J.A., Tomlinson I.D., Zlibut E., Ellis B.M., May J.C., McLean J.A., Hercules D.M., Mass spectrometry and ion mobility study of poly(ethylene glycol)‐based polyurethane oligomers, Rapid Communications in Mass Spectrometry, 2020, 34, S2.


144. Ellis B.M., Fischer C.N., Martin L.B., Bachmann B.O., McLean J.A. Spatiochemically Profiling Microbial Interactions with Membrane Scaffolded Desorption Electrospray Ionization-Ion Mobility-Imaging Mass Spectrometry and Unsupervised Segmentation, Anal Chem 2019, 91:21, 13703-13711.


143. Poland J.C., Schrimpe-Rutledge A.C., Sherrod S.D., Flynn C.R., McLean J.A. Utilizing untargeted ion mobility-mass spectrometry to profile changes in the gut metabolome following biliary diversion surgery, Anal Chem 2019, 91:22, 14417-14423.



142. Crescentini T.M., May J.C., McLean J.A., Hercules D.M. Mass spectrometry of polyurethanes, Polymer 2019, 181, 121624.


141. Harris R.A., Leaptrot K.L., May J.C., McLean J.A. New frontiers in lipidomics analyses using structurally selective ion mobility-mass spectrometry, Trends Analyt Chem 2019, 116: 316-323.


140. Crescentini T.M., May J.C., McLean J.A., Hercules D.M. Alkali metal cation adduct effect on polybutylene adipate oligomers: Ion mobility-mass spectrometry, Polymer 2019, 173: 58-65.


139. Palmer L.D., Jordan A.T., Maloney K.N., Farrow M.A., Gutierrez D.B., Gant-Branum R., Burns W.J., Romer C.E., Tsui T., Allen J.L., Beavers W.N., Nei Y.W., Sherrod S.D., Lacy D.B., Norris J.L., McLean J.A., Caprioli R.M., Skaar E.P. Zinc intoxication induces ferroptosis in A549 human lung cells, Metallomics 2019, 11: 982-993.


Book Chapter

138. Jiang W, Chung NA, May JC, McLean JA, Robinson RAS (2019). Ion Mobility-Mass Spectrometry. In Encyclopedia of Analytical Chemistry (pp. 1–34). John Wiley & Sons, Ltd.


137. Plante P.L., Francovic-Fontaine É., May J.C., McLean J.A., Baker E.S., Laviolette F., Marchand M., Corbeil J. Predicting Ion Mobility Collision Cross-Sections Using a Deep Neural Network: DeepCCS, Anal. Chem. 2019, 91(8):5191-5199.


136. Morris C.B., May J.C., Leaptrot K.L., McLean J.A. Evaluating Separation Selectivity and Collision Cross Section Measurement Reproducibility in Helium, Nitrogen, Argon, and Carbon Dioxide Drift Gases for Drift Tube Ion Mobility-Mass Spectrometry, J. Am. Soc. Mass Spectrom. 2019, (6):1059-1068.


Book Chapter

135. Phillips S.T., Dodds J.N., May J.C., McLean J.A. Isomeric and Conformational Analysis of Small Drug and Drug-Like Molecules by Ion Mobility-Mass Spectrometry (IM-MS), Methods Mol. Biol. 2019,1939:161-178.


134. Leaptrot K.L., May J.C., Dodds J.N., McLean J.A. Ion mobility conformational lipid atlas for high confidence lipidomics, Nat. Commun. 2019, 10(1):985.



133. Picache J.A., Rose B.S., Balinski A., Leaptrot K.L., Sherrod S.D., May J.C., McLean J.A. Collision cross section compendium to annotate and predict multi-omic compound identities, Chem. Sci. 2018, 10(4):983-993.


132. Gabelica V., Shvartsburg A.A., Afonso C., Barran P., Benesch J.L.P., Bleiholder C., Bowers M.T., Bilbao A., Bush M.F., Campbell J.L., Campuzano I.D.G., Causon T., Clowers B.H., Creaser C.S., De Pauw E., Far J., Fernandez-Lima F., Fjeldsted J.C., Giles K., Groessl M., Hogan C.J. Jr, Hann S., Kim H.I., Kurulugama R.T., May J.C., McLean J.A., Pagel K., Richardson K., Ridgeway M.E., Rosu F., Sobott F., Thalassinos K., Valentine S.J., Wyttenbach T. Recommendations for reporting ion mobility Mass Spectrometry measurements, Mass Spectrom. Rev. 2019, 9999, 1-30.



131. Crescentini T.M., Stow S.M., Forsythe J.G., May J.C., McLean J.A., Hercules D.M. Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry and Tandem Mass Spectrometry: IV. 3-Ring and 4-Ring Isomers, Anal. Chem. 2018, 90(24): 14453-14461.


130. Nichols C.M., Dodds J.N., Rose B.S., Picache J.A., Morris C.B., Codreanu S.G., May J.C., Sherrod S.D., McLean J.A. Untargeted Molecular Discovery in Primary Metabolism: Collision Cross Section as a Molecular Descriptor in Ion Mobility-Mass Spectrometry, Anal. Chem. 2018, 90(24):14484-14492.


link to publication 129. Gutierrez D.B., Gant-Branum R.L., Romer C.E., Farrow M.A., Allen J.L., Dahal N., Nei Y.-W., Codreanu S.G., Jordan A.T., Palmer L.D., Sherrod S.D., McLean J.A., Skaar E.P., Norris J.L., Caprioli R.M. An Integrated, High-throughput Strategy for Multi-Omic Systems Level Analysis, J. Proteome Res. 2018, 17(10): 3396-3408.



128. Philips S.T., Dodds J.N., Ellis B.M., May J.C., McLean J.A. Chiral Separations of Diastereomers of the Cyclic Nonapeptides Vasopressin and Desmopressin by Uniform Field Ion Mobility Mass Spectrometry, Chem. Commun. 2018, 54(68): 9398-9401.



Wikswo J.P., Cliffel D.E., Markov D.A., McLean J.A., McCawley L.J., Samson P.C., Reiserer R.S., Block F.E., McKenzie J.R. (2018) Integrated Organ-on-Chip System and Applications of the Same. U.S. Patent No. US10444223 B2.


127. May J.C., Jurneczko E., Stow S.M., Kratochvil I., Kalkhof S., McLean J.A. Conformational Landscapes of Ubiquitin, Cytochrome c, and Myoglobin: Uniform Field Ion Mobility Measurements in Helium and Nitrogen Drift Gas. Int. J. Mass Spectrom. 2018, 427:79-90.


Book Chapter

126. Dodds J.N., May J.C., McLean J.A., Chiral Analysis in Mass Spectrometry: Applications of Chromatography and Ion Mobility in Chiral Analysis: Advances in Spectroscopy, Chromatography, and Emerging Methods, 2nd Ed., P. Polavarapu, Ed. Elsevier 2018, p. 631-646.


125. Gibson C.L., Codreanu S.G., Schrimpe-Rutledge A.C., Retzlaff C.L., Wright J., Mortlock D.P., Sherrod S.D., McLean J.A., Blakely R.D. Global Untargeted Serum Metabolomic Analyses Nominate Metabolic Pathways Dependent on Expression of the Orphan Metallo B-Lactamase, MBLAC1, Mol. Omics 2018, 14: 142-155.



Link to article 124. Rogers M., Sobolik T., Schaffer D.K., Samson P.C., Johnson A.C., Owens P., Codreanu S.G., Sherrod S.D., McLean J.A., Wikswo J.P., Richmond A. Engineered Microfluidic Bioreactor for Examining the Three-Dimensional Breast Tumor Microenvironment, Biomicrofluidics 2018, 12(3): 034102.


Link to article 123. Nichols C.M., May J.C., Sherrod S.D., McLean J.A. Automated Flow Injection Method for the High Precision Determination of Drift Tube Ion Mobility Collision Cross Sections, Analyst 2018, 143: 1556-1559.


Link to article 122. Harris R.A., May J.C., Stinson C.A., Xia Y., McLean J.A. Determining Double Bond Position in Lipids Using Online Ozonolysis Coupled to Liquid Chromatography and Ion Mobility-Mass Spectrometry, Anal. Chem. 2018, 90(3): 1915-1924.


Link to article 121. Schrimpe-Rutledge A.C., Sherrod S.D., McLean J.A. Improving the Discovery of Secondary Metabolite Natural Products Using Ion Mobility-Mass Spectrometry, Curr. Opin. Chem. Biol. 2018, 42: 160-166.



Link to article 120. May J.C., Jurneczko E., Stow S.M., Kratochvil I., Kalkhof S., McLean J.A. Conformational Landscapes of Ubiquitin, Cytochrome c, and Myoglobin: Uniform Field Ion Mobility Measurements in Helium and Nitrogen, Int. J. Mass Spectrom. 2018, 427: 79-90.



Link to article 119. Dodds J.N., May J.C., McLean, J.A. Correlating Resolving Power, Resolution and Collision Cross Section: Unifying Cross-Platform Assessment of Separation Efficiency in Ion Mobility Spectrometry, Anal. Chem. 2017, 89(22): 12176-12184.


Link to article 118. Stow S.M., Crescentini T.M., Forsythe J.G., May J.C., McLean J.A., Hercules D.M. Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility and Mass Spectrometry: III MALDI Spectra of 2-Ring Isomers, Anal. Chem. 2017, 89(18): 9900-9910.


Link to article 117. Matta P., Sherrod S.D., Marasco C.C., Moore D.J., McLean J.A., Weitkamp J.-H. In Utero Exposure to Histological Chorioamnionitis Primes the Exometabolomic Profiles of Preterm CD4+ T Lymphocytes, J. Immunology 2017, 199(7).



Wikswo J.P., Samson P.C., Block F.E., Reiserer R.S., Parker K.K., McLean J.A., McCawley L.J., Markov D., Levner D., Ingber D.E., Hamilton G.A., Goss J.A., Cunningham R., Cliffel D.E., McKenzie J.R., Bahinski A., Hinojosa C.D. (2017) Integrated human organ-on-chip microphysiological systems, U.S. Patent No. US9725687B2.


Link to article 116. Stow S.M., Causon T.J., Zheng X., Kurulugama R.T., Mairinger T., May J.C., Rennie E.E., Baker E.S., Smith R.D., McLean J.A., Hann S., Fjeldsted J.C.. McLean J.A. An Interlaboratory Evaluation of Drift Tube Ion Mobility-Mass Spectrometry Collision Cross Section Measurements, Anal. Chem. 2017, 89(17): 9048-9055.


Link to article 115. Norris J.L., Farrow M.A., Gutierrez D.B., Palmer L.D., Muszynski N., Sherrod S.D., Pino J.C., Allen J.L., Spraggins J.M., Lubbocks A.L.R., Jordan A., Burns W., Poland J.C., Romer C., Manier M.L., Nei Y, Prentice B.M., Rose K.L., Hill S., Van de Plas R., Tsui T., Braman N.M., Keller M.R., Rutherford S.A., Lobdell N., Lopez C.F., Lacy DB, McLean J.A., Wikswo J.P., Skaar E.P., Caprioli, R.M. Integrated, High-Throughput, Multiomics Platform Enables Data-Driven Construction of Cellular Responses and Reveals Global Drug Mechanisms of Action, J. Proteome Res. 2017, 16(3): 1364-1375.


Link to article 114. Dodds J.N., May J.C., McLean J.A. Investigation of the Complete Suite of the Leucine and Isoleucine Isomers: Towards prediction of Ion Mobility Separation Capabilities, Anal. Chem. 2017, 89(1): 952-959.


Link to article 113. May J.C., Morris C.B., McLean J.A. Ion Mobility Collision Cross Section Compendium, Anal. Chem. 2017, 89(2): 1032-1044.


Link to article


112. Covington B.C., McLean J.A., Bachmann B.O. Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites, Nat. Prod. Rep. 2017140: 3295-3307.



Link to article 111. Harper B., Neumann E.K., Stow S.M., May J.C., McLean J.A. Determination of Ion Mobility Collision Cross Sections for Unresolved Isomeric Mixtures Tandem Mass Spectrometry and Chemometric Deconvolution, Analytica Chimica Acta 2016, 939: 64-72.


Link to article 110. Schrimpe-Rutledge A.C., Codreanu S.G., Sherrod S.D., McLean J.A. Untargeted Metabolomics Strategies: Challenges and Emerging Directions, J. Am. Soc. Mass Spectrom. 201627: 1897-1905.


Link to article 109. Montenegro-Burke R.J., Sutton J.A., Rogers L.M., Milne G.M., McLean J.A., Aronoff D.M. Lipid Profiling of Polarized Human Monocyte-derived Macrophages, Prostaglandins Other Lipid Mediat. 2016, 88: 7329-7336.


Link to article 108. Hines K.M., May J.C., McLean J.A., Xu L. Evaluation of Collision Cross Section Calibrants for Structural Analysis of Lipids by Traveling Wave Ion Mobility-Mass Spectrometry, Anal. Chem. 2016, 88: 7329-7336.


Link to article 107. May J.C., McLean, J.A. Advanced Multidimensional Separations in Mass Spectrometry: Navigating the Big Data Deluge, Annu. Rev. in Anal. Chem. 2016, 9: 387-409.


Link to article 106. May J.C., Gant-Branum R.L., McLean J.A. Targeting the Untargeted in Molecular Phenomics with Structural Mass Spectrometry, Curr. Opin. Biotechnol. 2016, 39: 192-197.


Link to article 105. Spears B.R., Marin M.A., Montenegro-Burke J.R., Evans B.C., McLean J.A., Harth E. Aqueous Epoxide Ring-Opening Polymerization (AEROP): Green Synthesis of Polyglycidol with Ultralow Branching, Macromolecules 2016, 49: 2022-2027.


Link to article 104. Montenegro-Burke J.R., Bennett J.M., McLean J.A., Hercules, D.M. Novel Behavior of the Chromatographic Separation of Linear and Cyclic Polymers, Anal. Bioanal. Chem. 2016, 408: 677-681.



Link to article 103. Sherrod S.D., McLean J.A. Systems-Wide High-Dimensional Data Acquisition and Informatics Using Structural Mass Spectrometry Strategies, Clin. Chem. 2016, 62: 77-83.


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Link to article 102. May J.C., Dodds J.N., Kurulugama R.T., Stafford G., Fjeldsted J., McLean J.A. Broadscale Resolving Power Performance of a High Precision Uniform Field Ion Mobility-Mass Spectrometer, Analyst 2015, 140: 6824-6833.


Link to article 101. Farrand A.J., Haley K.P., Lareau N.M., Heilbronner S., McLean J.A., Foster T., Skaar E.P. An Iron-regulated Autolysin Remodels the Cell Wall to Facilitate Heme Acquisition in Staphylococcus lugdunensis, Infect. Immun. 2015, 83: 3578-3589.


Link to article 100. Derewacz D.K., Covington B.C., McLean J.A., Bachmann B.O. Mapping Microbial Response Metabolomes for Induced Natural Product Discovery, ACS Chem. Biol. 2015, 10: 1998-2006.


Link to article 99. May J.C., McLean J.A. A Uniform Field Ion Mobility Study of Melittin and Implications of Low-Field Mobility for Resolving Fine Cross-Sectional Detail in Peptide and Protein Experiments, Proteomics 2015, 15: 2862-2871.


Link to article 98. Stow S.M., Onifer T.M., Forsythe J.G., Nefzger H., Kwiecien N.W., May J.C., McLean J.A., Hercules D.M. Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies: II. Electrospray Spectra of 3-Ring and 4-Ring Isomers, Anal. Chem. 2015, 87: 6288-6296


Link to article 97. Goodwin C.R., Covington B.C., Derewacz D.K., McNees C.R., Wikswo J.P., McLean J.A., Bachmann B.O. Structuring Microbial Metabolic Responses to Multiplexed Stimuli Via Self-Organizing Metabolomics Maps, Chem. Biol. 2015, 22: 661-670.


Link to article 96. Gies A.P., Stow S.M., McLean J.A., Hercules D.M. MALDI-TOF/TOF CID Study of Poly(1,4-dihydroxybenzene terephthalate) Fragmentation Reactions, Polymer 2015, 64: 100-111.


Link to article 95. Xu L., Kliman M., Forsythe J.G., Korade Z., Hmelo A.B., Porter N.A., McLean J.A. Profiling and Imaging Ion Mobility-Mass Spectrometry Analysis of Cholesterol and 7-Dehydrocholesterol in Cells Via Sputtered Silver MALDI, J. Am. Soc. Mass Spectrom. 2015, 26: 924-933.


Link to article


94. Lareau N.M., May J.C., McLean J.A. Non-derivatized Glycan Analysis by Reverse Phase Liquid Chromatography and Ion Mobility-Mass Spectrometry, Analyst 2015, 140: 3295-3307.


Link to article


93. May J.C., McLean J.A. Ion Mobility-Mass Spectrometry: Time-Dispersive Instrumentation, Anal. Chem. 2015, 87: 1422-1436.



Link to article 92. Marasco C.C., Enders J.R., Seale K.T., McLean J.A., Wikswo J.P. Real-Time Cellular Exometabolome Analysis with Microfluidic-Mass Spectrometry Platform, PLOS One 201510: e0117685.


Link to article 91. Sumner L.W., Styczynski M., McLean J.A., Fiehn O., Jander G., Liao J., Sumner S., Britz-McKibbin P., Welti R., Jones A.D., Dorrestein P.C., Bearden D., Kaddurah-Daouk R. Introducing the USA Plant, Algae and Microbial Metabolomics Research Coordination Network (PAMM_NET), Metabolomics 201511: 3-5.


Link to article 90. Kumar K.K., Goodwin C.R., Uhouse M.A., Bornhorst J., Schwerdtle T., Aschner M., McLean J.A., Bowman A.B. Untargeted metabolic profiling identifies interactions between Huntington’s disease and neuronal manganese status, Metallomics 20157: 363-370.


Link to article 89. French W.R., Zimmerman L.J., Schilling B., Gibson B.W., Miller C.A., Townsend R.R., Sherrod S.D., Goodwin C.R., McLean J.A., Tabb D.L. Wavelet-Based Peak Detection and a New Charge Inference Procedure for MS/MS Implemented in ProteoWizard’s msConvert, J. Proteome Res. 201514: 1299-1307.


Link to article 88. May J.C., Goodwin C.R., McLean J.A. Ion mobility-mass spectrometry strategies for untargeted systems, synthetic, and chemical biology, Curr. Opin. Biotechn. 201531: 117-121.



Link to article 87. Stow S.M., Goodwin C.R., Kliman M., Bachmann B.O., McLean J.A., Lybrand T.P. Distance Geometry Protocol to Generate Conformations of Natural Products to Structurally Interpret Ion Mobility-Mass Spectrometry Collision Cross Sections, J. Phys. Chem. B 2014, 118 (48): 13812-13820.


Link to article 86. Brown J.A., Sherrod S.D., Goodwin C.R., Brewer B., Yang L., Garbett K.A., Li D., McLean J.A., Wikswo J.P., Mirnics K. Metabolic consequences of interleukin-6 challenge in developing neurons and astroglia, J. Neuroinflammation 2014, 11, 183.


Link to article 85. Marasco C.C., Goodwin C.R., Seale K.T., Winder D., Schramm-Sapyta N., McLean J.A., Wikswo J.P. Systems level view of cocaine addiction: the interconnect of immune and nervous systems, Experim. Biol. .Med. 2014, 239(11): 1433-1442.


Book Chapter

84. Stow S.M., Lareau N.M., Hines K.M., McNees C.R., Goodwin C.R., Bachmann B.O., McLean J.A., Structural Separations for Natural Product Characterization by Ion Mobility Mass Spectrometry: Fundamental Theory to Emerging Applications in Natural Products Analysis: Instrumentation, Methods, and Applications. Vladimir Havlicek and Jaroslav Spizek, Eds. John Wiley & Sons, Inc. 2014.


Link to article


83. Hines K.M., Ballard B.R., Marshall D.R., McLean J.A. Structural mass spectrometry of tissue extracts to distinguish cancerous and non-cancerous breast diseases, Mol. BioSyst. 2014, 10, 2827-2837.


Link to article 82. Hendricks N.G., Lareau N.M., Stow S.M., McLean J.A., Julian R.R. Bond-Specific Dissociation Following Excitation Energy Transfer for Distance Constraint Determination in the Gas Phase, J. Am. Chem. Soc. 2014, 136(38): 13363-13370.


Link to article 81. Evans J.C., Hines K.M., Forsythe J.G., Erdogan B., Shi M., Hill S., Rose K.L., McLean J.A., Webb D.J. Phosphorylation of Serine 106 in Asef2 Regulates Cell Migration and Adhesion Turnover, J. Prot. Res. 2014, 13(7): 3303-3313.


Link to article 80. Goodwin C.R., Sherrod S.D., Marasco C.C., Bachmann B.O., Schramm-Sapyta N.L., Wikswo J.P., McLean J.A. Phenotypic mapping of metabolic profiles using self-organizing maps of high-dimensional mass spectrometry data, Anal. Chem. 2014, 86(13): 6563-6571.


Link to article 79. Forsythe J.G., Stow S.M., Nefzger H., Kwiecien N.W., May J.C., McLean J.A., Hercules D.M. Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies: I. Electrospray Spectra of 2-Ring Isomers, Anal. Chem. 2014, 86(9): 4362-4370.


Link to article 78. May J.C., Goodwin C.R., Lareau N.M., Leaptrot K.L., Morris C.B., Kurulugama R.T., Mordehai A., Klein C., Barry W., Darland E., Overney G., Imatani K., Stafford G.C., Fjeldsted J.C., McLean J.A., Conformational Ordering of Biomolecules in the Gas-Phase: Nitrogen Collision Cross-Sections Measured on a Prototype High Resolution Drift Tube Ion Mobility-Mass Spectrometer, Anal. Chem.  2014, 86(4): 2107-2116.


Link to article 77. Lamberson C.R., Xu L., Muchalski H., Montenegro-Burke J.R., Shmanai V.V., Bekish A.V., McLean J.A., Clarke C.F., Shchepinov M.S., Porter N.A. Unusual Kinetic Isotope Effects of Deuterium Reinforced Polyunsaturated Fatty Acids in Tocopherol-Mediated Free Radical Chain Oxidations, J. Am. Chem. Soc. 2014, 136(3): 838-841.



Link to article 76. Alcendor D.J., Block III F.E., Cliffel D.E., Daniels J.S., Ellacott K.L.J., Goodwin C.R., Hofmeister L.H., Li D., Markov D.M., May J.C., McCawley L.J., McLaughlin B., McLean, J.A., Niswender K.D., Pensabene V., Seale K.T., Sherrod S.D., Sung H.-J., Tabb D.L., Webb D.J., Wikswo J.P. Neurovascular Unit on a Chip: Implications for Translational Applications, Stem Cell Research and Therapy 2013, 4 (Suppl 1): S18.


Link to article 75. Shi M., Majumdar D., Gao Y., Brewer B.M., Goodwin C.R., McLean J.A., Li D., Webb D.J. Glia co-culture with neurons in microfluidic platforms promotes the formation and stabilization of synaptic contacts, Lab Chip 2013, 13: 3008-3021.


Book Chapter

74. May JC, Goodwin CR, McLean JA, Gas-Phase Ion Mobility-Mass Spectrometry (IM-MS) and Tandem IM-MS Strategies for Metabolism Studies and Metabolomics, in Encyclopedia of Drug Metabolism and Interactions, 6-Volume Set, D. C. Muddiman, Ed., John Wiley and Sons, 1-29 (2013).


Link to article 73. Hines K.M., Ashfaq S., Davidson J.M., Opalenik S.R., Wikswo J.P., McLean J.A. Biomolecular Signatures of Diabetic Wound Healing by Structural Mass Spectrometry, Anal. Chem. 2013, 85(7): 3651-3659.


Link to article 72. May J.C., McLean J.A. The influence of drift gas composition on the separation mechanism in traveling wave ion mobility spectrometry: insight from electrodynamic simulations, Int. J. Ion Mobil. Spectrom.  2013, 16: 85-94.


Link to article 71. Block III F.E., Cliffel D.E., Goodwin C.R., Marasco C.C., Markov D.A., McLean D.L., McLean J.A., McKenzie J.R., Reiserer R.S., Samson P.C., Schaffer D.K., Seale K.T., Sherrod S.D., Wikswo J.P. Engineering Challenges for Instrumenting and Controlling Integrated Organ-on-Chip Systems, IEEE Trans. .Biomed. Eng.  2013, 60(3): 682-690.


Link to article 70. Derewacz D.K., Goodwin C.R., McNees C.R., McLean J.A., Bachmann B.O. Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism, Proc. Natl. Acad. Sci. U.S.A. 2013, 110(6): 2336-2341.


Book Chapter

69. Fenn L.S., McLean J.A. Structural Separations by Ion Mobility-MS for Glycomics and Glycoproteomics in Mass Spectrometry of Glycoproteins: Methods and Protocols. Jennifer J. Kohler and Steven M. Patrie, Eds. Humana Press. 2013.



Link to article 68. Forsythe J.G., Broussard J.A., Lawrie J.L., Kliman M., Jiao Y., Weiss S.M., Webb D.J., McLean J.A., Semitransparent Nanostructured Films for Imaging Mass Spectrometry and Optical Microscopy, Anal. Chem. 2012, 84(24): 10665-10670.


Book Chapter

67. Hines K.M., Enders J.R., McLean J.A., Multidimensional Separations by Ion Mobility-Mass Spectrometry in Encyclopedia of Analytical Chemistry. Robert Myers and David Muddiman Eds. John Wiley & Sons, Ltd. December 2012.


Link to article 66. Committee on Assessment of Agent Monitoring Strategies for the Blue Grass and Pueblo Chemical Agent Destruction Pilot Plants, Board on Army Science and Technology, Division on Engineering and Physical Sciences, National Research Council (NRC Committee: C.E. Kolb (Chair), J.L. Beauchamp, R.A. Beaudet, J.B. Berkowitz, H. Chem, A.T. Cooper, F.M. Fernandez, R.D. Gibbons, J.A. McLean, M.D. Morris, D.W. Murphy, C.S. Reese, L.R. Rhomberg, and A.A. Viggiano. “Executive Summary.” Assessment of Agent Monitoring Strategies for the Blue Grass and Pueblo Chemical Agent Destruction Pilot Plants. Washington, DC: The National Academies Press 2012.


Link to article 65. Enders J.R., Marasco C.C., Wikswo J.P., McLean J.A. A Dual-Column Solid Phase Extraction Strategy for Online Collection and Preparation of Continuously Flowing Effluent Streams for Mass Spectrometry, Anal. Chem. 2012, 84(20): 8467-8474.


Link to article 64. Harkness K.M., Tang Y., Dass A., Pan J., Kothalawala N., Reddy V.J., Cliffel D.E., Demeler B., Stellacci F., Bakr O.M., McLean J.A. Ag44(SR)304-: a silver-thiolate superatom complex, Nanoscale 2012, 4: 4269-4274.


Link to article 63. Harkness K.M., Turner B.N., Agrawal A.C., Zhang Y., McLean J.A., Cliffel D.E. Biomimetic monolayer-protected gold nanoparticles for immunorecognition, Nanoscale 2012, 4: 3843-3851.


Link to article 62. Matusch A., Fenn L.S., Depboylu C., Klietz M., Strohmer S., McLean J.A., Becker J.S. Combined elemental and biomolecular mass spectrometry imaging (MSI) for probing the inventory of tissue at a micrometer scale, Anal._Chem. 2012, 84(7): 3170-3178.


Link to article 61. Goodwin C.R., Fenn L.S., Derewacz D.K., Bachmann B.O., McLean J.A., Structural Mass Spectrometry: Rapid Methods for Separation and Analysis of Peptide Natural Products, J._Nat._Prod. 2012, 75(1): 48-53.



Link to article 60. Enders J.R., Goodwin C.R., Marasco C.C., Seale K.T., Wikswo J.P., McLean J.A. Advanced structural mass spectrometry for systems biology: Pulling the needles from haystacks, Spectrosc. Supp. Curr. Trends Mass Spectrom 2011, 18-23.


Link to article 59. Harkness K.M., Balinski A., McLean J.A., Cliffel D.E. Nanoscale phase segregation of mixed thiolates on gold nanoparticles, Angew. Chem. (International) 2011, 50(45): 10554–10559.


Link to article 58. Kliman M., May J.C., McLean J.A. Lipid analysis and lipidomics by structurally selective ion mobility-mass spectrometry, Biochimica et Biophysica Acta 2011, 1811(11): 935-945. Invited submission for special issue entitled Lipidomics and Imaging Mass Spectrometry.


Book Chapter

57. Enders J.R., Kliman M., Sundarapandian S., McLean J.A. Peptide and Protein Analysis using Ion Mobility-Mass Spectrometry in Protein and Peptide Mass Spectrometry in Drug Discovery. Michael L. Gross, Ben Pramanik, Guodong Chen Eds. John Wiley & Sons, Inc. 2011, p. 139-174.



Book Chapter

56. May J.C., McLean J.A. The conformational landscape of biomolecules in ion mobility-mass spectrometry. Invited chapter for inclusion in Ion Mobility Spectrometry: Theory and Applications, Charles L. Wilkins and Sarah Trimpin Eds. CRC Press 2011, p.327-343.


Link to article 55. Kerr T.J., Gant-Branum R.L., McLean J.A. Multiplexed analysis of peptide functionality using lanthanide-based structural shift reagents, Int. J. Mass Spectrom. 2011, 307(1-3): 28-32. Invited submission for special issue honoring H. Joachim-Dietze.


Link to article 54. Fenn L.S., McLean J.A. Structural resolution of carbohydrate positional and structural isomers based on gas-phase ion mobility-mass spectrometry, Phys. Chem. .Chem. Phys. 2011, 13(6): 2196-2205.



Link to article 53. Harkness K., Hixson B., Fenn F., Turner, B., Rape A., Simpson C., Huffman B., Okoli T., McLean J.A., Cliffel D.E. A Structural Mass Spectrometry Strategy for the Relative Quantitation of Ligands on Mixed Monolayer-Protected Gold Nanoparticles, Anal. Chem. 2010, 82(22):268-9274.


Book Chapter

52. McLean J.A., Schultz J.A., Woods A.S. Ion Mobility-Mass Spectrometry for Biological and Structural Mass Spectrometry in Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicabilities, and Biological Applications, Richard B. Cole, Ed. John Wiley & Sons 2010, pgs. 411-439.


Link to article 51. Enders J.R., Marasco C.C., Kole A., Nguyen B., Sundarapandian S., Seale K.T.,  Wikswo J.P., McLean J.A. Towards monitoring real-time cellular response using an integrated microfluidics-MALDI/nESI-ion mobility-mass spectrometry platform, IET Syst. Biol. 2010, 4 (6):416-427.


Link to article 50. Kerr T.J., McLean J.A. Peptide quantitation using primary amine selective metal chelation labels for mass spectrometry, Chem. Comm. 2010, 46:5479-5481.


Link to article 49. Sevugarajan S., May J.C., McLean J.A. A dual source ion mobility-mass spectrometer for direct comparison of ESI and MALDI collision cross section measurements, Anal. Chem. 2010, 82(8):3247-3254.


Link to article 48. Harkness K., Fenn L.S., Cliffel D.E., McLean J.A. Surface Fragmentation of Complexes from Thiolate Protected Gold Nanoparticles by Ion Mobility-Mass Spectrometry, Anal. Chem. 2010, 82(7):3061-3066.


Link to article


47. Kliman M., Vijayakrishnan N., Wang L., Tapp J.T., Broadie K., McLean J.A. Structural mass spectrometry analysis of lipid changes in a drosophila epilepsy model brain, Mol. BioSyst. 2010, 6(6):958-966.


Link to article 46. Ridenour W.B., Kliman M., McLean J.A., Caprioli R.M. Structural characterization of phospholipids and peptides directly from tissue sections by MALDI traveling-wave ion mobility-mass spectrometry, Anal. Chem. 2010, 82(5):1881-1889.


Link to article 45. McLean J.R., McLean J.A., Wu Z., Becker C.S., Perez L., Pace C.N., Scholtz J.M., Russell D.H. Factors that influence helical preferences for singly-charged gas-phase peptide ions: the side effects of multiple potential charge-carrying sites, J. Phys. Chem. B. 2010, 114(2):809-816.


Book Chapter

44. McLean J.A., Fenn L.S., Enders J.R. “Structurally Selective Imaging Mass Spectrometry by Imaging Ion Mobility-Mass Spectrometry” in Mass Spectrometric Imaging: Principles and Protocols, Methods in Molecular Biology Series, Jonathan Sweedler and Stanislav Rubakhin, Eds. Humana Press 2010, pgs.363-383 .


Link to article


McLean, J. A., Russell, D. H., Egan, T. F., Ugarov, M. V. and Schultz, J. A. (2010) Multiplex Data Acquisition Modes for Ion Mobility-Mass Spectrometry. U. S. Patent No. US7745780B2.


Link to article 43. Gant-Branum R.L., Broussard J.A., Mahsut A., Webb D.J., McLean J.A. Identification of phosphorylation sites within the signaling adaptor APPL1 by mass spectrometry, J. Proteome Res. 2010, 9(3):1541-1548.


Link to article 42. Harkness K., Cliffel D.E., McLean, J.A. Characterization of Thiolate-Protected Gold Nanoparticles by Mass Spectrometry, Analyst 2010, 135:868-874.


Link to article 41. Enders J. R., McLean J. A. Chiral and Structural Analysis of Biomolecules Using Mass Spectrometry and Ion Mobility-Mass Spectrometry. Chirality 2009, 21:S253-S264.


Link to article


40. Fenn L.S., McLean J.A. Simultaneous glycoproteomics on the basis of structure using ion mobility-mass spectrometry. Mol. BioSyst. 2009, 5:1298-1302.


Link to article 39. Huang Y., Marini J.A., McLean J.A., Tichy S.E., Russell D.H. A Mechanistic Study of H/D Exchange Reactions of Protonated Arginine and Arginine-Containing Di- and Tripeptides. J. Am. Soc. Mass Spectrom. 2009, 20(11):2049-2057.


Link to article 38. McLean J.A. The mass-mobility correlation redux: the conformational landscape of anhydrous biomolecules. J. Am. Soc. Mass Spectrom. 2009, 20(10):1775-1781.


Link to article 37. Gant-Branum R.L., Kerr T.J, McLean J.A. Labeling Strategies in Mass Spectrometry-Based Protein Quantitation. Analyst. 2009, 134(8):1525-1530.


Link to article 36. Phelan V.V., Du Y., McLean J.A., Bachmann B.O., Adenylation Enzyme Discovery and Characterization using γ-18O4-ATP – Pyrophosphate Exchange. Chem. Biol. 2009, 16(5):473-478.


Link to article 35. Fenn L.S., Kliman M., Mahsut A., Zhao S.R., McLean J.A. Characterizing ion mobility-mass spectrometry conformation space for the analysis of complex biological samples. Anal. Bioanal. Chem. 2009, 394(1):235-44.



Link to article 34. Fenn L.S., McLean J.A. Enhanced carbohydrate structural selectivity in ion mobility-mass spectrometry analyses by boronic acid derivatization. Chem. Comm. 2008, 43: 5505-5507.


Link to article 33. Gies A.P., Kliman M., McLean J.A., Hercules D.M. Characterization of Branching in Aramid Polymers Studied by MALDI-Ion Mobility/Mass Spectrometry. Macromolecules. 2008, 41 (22): 8299-8301.


Link to article 32. Fenn, L. S., McLean, J. A. Biomolecular Structural Separations by Ion Mobility-Mass Spectrometry. Anal. Bioanal. Chem. 2008, 391(3): 905-909.


31. McLean, J. A., Russell, D. H. Advanced Optics for Rapidly Patterned Laser Profiles in Analytical Mass Spectrometry. U. S. patent No. 2007: 7,282,706.

30. McLean J. A. , Ridenour W. B. , Caprioli R. M. Profiling and imaging of tissues by imaging ion mobility-mass spectrometry. Int. J. Mass Spectrom. 2007, 42 (8): 1099-1105.

29. Sherrod, S. D., Castellana, E. T., McLean, J. A. and Russell, D. H. Spatially dynamic laser patterning using advanced optics for imaging matrix assisted laser desorption/ionization (MALDI) mass spectrometry. J. of Mass Spectrom. 2007, 262: 256-262.

Prior to Vanderbilt University


McLean, J. A., Russell, D. H. and Schultz, J. A. Gas-Phase Purification of Biomolecules by Ion Mobility for Patterning Microarrays and Protein Crystal Growth. U.S. patent No. 2006: 7,081,617.


28. McLean, J. A., Ruotolo, B. T., Gillig, K. J., Russell, D. H. Ion Mobility-Mass Spectrometry: A New Paradigm for Proteomics. Int. J. Mass Spectrom. 2005, 240: 301-315.

27. McLean, J. A., Schultz, J. A., Ugarov, M. V., Egan, T. F., Russell, D. H. Ultrafast Two-Dimensional Ion Separations Based on Ion Mobility-Time-of-Flight Mass Spectrometry: From Biotechnology to Nanotechnology. Braz. J. Vac. Appl. 2005, 24: 3-9.

26. McLean, J. A., Stumpo, K. A., Russell, D. H. Size-Selected (2-10 nm) Gold Nanoparticles for Matrix Assisted Laser Desorption Ionization of Peptides. J. Am. Chem. Soc. 2005, 127: 5304-5305.

25. McLean, J. A., Russell, D. H. Multiplex Data Acquisition Based on Analyte Dispersion in Two Dimensions: More Signal More of the Time. Int. J. Ion Mobil. Spectrom. 2005, 8: 66-71.

24. McLean, J. A., Russell, D. H. New Vistas for New Vistas for Mass Spectrometry Based Proteomics and Biotechnology: Rapid Two-Dimensional Separations Using Gas-Phase Electrophoresis/Ion Mobility-Mass Spectrometry. Am. Biotech. Lab. 2005, 23: 18-21.

23. B. T. Ruotolo, J. A. McLean, K. J. Gillig, and D. H. Russell. The influence and utility of varying field strength for the separation of tryptic peptides by ion mobility-mass spectrometry. J. Am. Soc. Mass Spectrom. 2005, 16: 158-165.


22. B. T. Ruotolo, J. A. McLean, K. J. Gillig, and D. H. Russell. Peak capacity of ion mobility mass spectrometry: The utility of varying drift gas polarizability for the separation of tryptic peptides. J. Mass Spectrom. 2004, 39: 361-367.

21. C. S. Westphal, J. A. McLean, S. J. Hakspiel, W. E. Jackson, D. E. McClain, and A. Montaser. Determination of Depleted Uranium in Urine via Isotope Ratio Measurements Using Large-Bore Direct Injection High Efficiency Nebulizer-Inductively Coupled Plasma Mass Spectrometry. Appl. Spectrosc. 2004, 58: 1044-1050.


20. J. A. McLean, and D. H. Russell. Sub-Femtomole Peptide Detection in Ion Mobility-Time-of-Flight Mass Spectrometry Measurements. J. Proteome Res. 2003, 2: 427-430.

19. J. A. McLean, W. K. Russell, and D. H. Russell. A High Repetition Rate (1 kHz) Micro-Crystal Laser for High Throughput Atmospheric Pressure MALDI-Quadrupole-Time-of-Flight Mass Spectrometry. Anal. Chem. 2003, 75: 648-654.


18. J. M. Koomen, B. T. Ruotolo, K. J. Gillig, J. A. McLean, D. H. Russell, M. Kang, K. R. Dunbar, K. Fuhrer, M. Gonin, and J. A. Schultz. Oligonucleotide Analysis with MALDI-Ion Mobility-TOFMS. Anal. Bioanal. Chem. 2002, 373: 612-617.

17. S. F. Boulyga, J. L. Matusevich, V. P. Mironov, V. P. Kudrjashov, L. Halicz, I. Segal, J. A. McLean, A. Montaser, and J. S. Becker. Determination of 236U/238U Isotope Ratio in Contaminated Environmental Samples Using Different ICP-MS Instruments. J. Anal. At. Spectrom. 2002, 17: 958-964.

16. S-A. E. O’Brien, J. A. McLean, B. W. Acon, B. J. Eshelman, W. F. Bauer, and A. Montaser. Determination of Memory-Prone Elements Using Direct Injection High Efficiency Nebulizer Inductively Coupled Plasma Mass Spectrometry. Appl. Spectrosc. 2002, 56: 1006-1012.

15. C. S. Westphal, J. A. McLean, B. W. Acon, L. A. Allen, and A. Montaser. Axial Inductively Coupled Plasma Time-of-Flight Mass Spectrometry Using Direct Liquid Sample Introduction. J. Anal. At. Spectrom. 2002, 17: 669-675.


14. B. W. Acon, J. A. McLean, and A. Montaser. A Direct Injection High Efficiency Nebulizer Interface for Microbore High-Performance Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry. J. Anal. At. Spectrom. 2001, 16: 852-857.

13. J. A. McLean, J. S. Becker, S. Boulyga, H.-J. Dietze, and A. Montaser. Ultratrace and Isotopic Analysis of Long-Lived Radionuclides by Double-Focusing Sector Field Inductively Coupled Plasma Mass Spectrometry Using Direct Liquid Sample Introduction. Int. J. Mass Spectrom. 2001, 208: 193-204.

12. M. G. Minnich, J. A. McLean, and A. Montaser. Rapid Elucidation of Spatial Aerosol Characteristics of a Direct Injection High Efficiency Nebulizer via Optical Patternation. Spectrochim. Acta 2001, 56B: 1113-1126.


11. J. A. McLean, M. G. Minnich, A. Montaser, J. Su, and W. Lai. Optical Patternation: A Technique for Three Dimensional Aerosol Diagnostics. Anal. Chem. 2000, 72: 4796-4804.

10. B. W. Acon, J. A. McLean, and A. Montaser. A Large Bore-Direct Injection High Efficiency Nebulizer for Inductively Coupled Plasma Spectrometry. Anal. Chem. 2000, 72: 1885-1893.

9. J. A. McLean, B. W. Acon, A. Montaser, J. Singh, D. E. Pritchard, and S. R. Patierno. Determination of Chromium in Human Lung Fibroblast Cells Using a Large-Bore Direct Injection High Efficiency Nebulizer with Inductively Coupled Plasma Mass Spectrometry. Appl. Spectrosc. 2000, 54: 659-663.



8. J. Singh, D. E. Pritchard, D. L. Carlisle, J. A. McLean, A. Montaser, J. M. Orenstein, and S. R. Patierno. Internalization of Carcinogenic Lead Chromate Particles by Cultured Normal Human Lung Epithelial Cells: Formation of Intracellular Lead-Inclusion Bodies and Induction of Apoptosis. Toxicol. Appl. Pharmacol.. 1999, 161: 240-248.

7. J. A. McLean, R. A. Huff, and A. Montaser. Fundamental Aerosol Properties in Helium Using a Direct Injection Nebulizer. Appl. Spectrosc. 1999, 53: 1331-1340.

6. J. S. Becker, H.-J. Dietze, J. A. McLean, and A. Montaser. Ultratrace and Isotope Analysis of Long-Lived Radionuclides by Inductively Coupled Plasma Quadrupole Mass Spectrometry Using a Direct Injection High Efficiency Nebulizer. Anal. Chem. 1999, 71: 3077-3084.


5. Book Chapter: A. Montaser, J.A. McLean, H. Liu, and J-M. Mermet. “Introduction to ICP Spectrometries for Elemental Analysis”, in Inductively Coupled Plasma Mass Spectrometry. A. Montaser Ed. Wiley-VCH, New York. 1998.

4. Book Chapter: A. Montaser, M. G. Minnich, J. A. McLean, H. Liu, J. A. Caruso and C. W. McLeod. “Sample Introduction in ICPMS”, in Inductively Coupled Plasma Mass Spectrometry. A. Montaser Ed. Wiley-VCH, New York. 1998.

3. J. Singh, J. A. McLean, D. E. Pritchard, A. Montaser, and S. R. Patierno. Sensitive Quantitation of Chromium-DNA Adducts by Inductively Coupled Plasma Mass Spectrometry with a Direct Injection High Efficiency Nebulizer . Toxicol. Sci. 1998, 46: 260-265.

2. J. A. McLean, M. G. Minnich, L. A. Iacone, H. Liu, and A. Montaser. Nebulizer Diagnostics: Fundamental Parameters, Challenges, and Techniques on the Horizon. J. Anal. At. Spectrom. 1998, 13: 829-842.

1. J. A. McLean, H. Zhang, and A. Montaser. A Direct Injection High-Efficiency Nebulizer for Inductively Coupled Plasma Mass Spectrometry. Anal. Chem. 1998, 70: 1012-1020.