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Sulikowski Lab

Sulikowski Lab Publications

2019

Williams Jade C. , Sheldon Jessica R. , Imlay Hunter D. , Dutter Brendan F. , Draelos Matthew M. , Skaar Eric P. , Sulikowski Gary A. , Synthesis of the Siderophore Coelichelin and Its Utility as a Probe in the Study of Bacterial Metal Sensing and Response Organic Letters. 2019 Jan 15; ASAP

2018

Yamanashi H. , Boeglin W.E. , Morisseau C. , Davis R.W. , Sulikowski G.S. , Hammock B.D. , Brash A.R. , Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function. J Lipid Res.. 2018 Feb 19; 4 (59). 684-695
Abney A.A. , Ramos-Hunter S.J. , Romaine I.M. , Goodwin J.S. , Sulikowski G.A. , Weaver C.D. , Selective Activation of N,N’-Diacyl Rhodamine Pro-fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE). Chemistry. 2018 May 25; 36 (24). 8985-8988
Dutter B.F. , Ender A. , Sulikowski G.A. , Weaver C.D. , Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org. Biomol. Chem.. 2018 Aug 8; 31 (16). 5575-5579
Boer R.E. , Giménez-Bastida J.A. , Boutaud O. , Jana S. , Schneider C. , Sulikowski G.A. , Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2 Org. Lett.. 2018 Jun 19; 13 (20). 4020-4022

2017

Azumaya CM , Days EL , Vinson PN , Stauffer S , Sulikowski G , Weaver CD , Nakagawa T , Screening for AMPA receptor auxiliary subunit specific modulators. PloS one. 2017 ; 12 (3). e0174742
Rai G , Brimacombe KR , Mott BT , Urban DJ , Hu X , Yang SM , Lee TD , Cheff DM , Kouznetsova J , Benavides GA , Pohida K , Kuenstner EJ , Luci DK , Lukacs CM , Davies DR , Dranow DM , Zhu H , Sulikowski G , Moore WJ , Stott GM , Flint AJ , Hall MD , Darley-Usmar VM , Neckers LM , Dang CV , Waterson AG , Simeonov A , Jadhav A , Maloney DJ , Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of medicinal chemistry. 2017 Nov 22; 60 (22). 9184-9204
Surdel MC , Horvath DJ , Lojek LJ , Fullen AR , Simpson J , Dutter BF , Salleng KJ , Ford JB , Jenkins JL , Nagarajan R , Teixeira PL , Albertolle M , Georgiev IS , Jansen ED , Sulikowski GA , Lacy DB , Dailey HA , Skaar EP , Antibacterial photosensitization through activation of coproporphyrinogen oxidase. Proceedings of the National Academy of Sciences of the United States of America. 2017 Aug 8; 114 (32). E6652-E6659
Lepesheva G , Christov P , Sulikowski GA , Kim K , A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors. Tetrahedron letters. 2017 Nov 8; 58 (45). 4248-4250

2016

Dutter BF , Mike LA , Reid PR , Chong KM , Ramos-Hunter SJ , Skaar EP , Sulikowski GA , Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus. ACS chemical biology. 2016 Mar 4;
Chong KM , Leelatian N , Deguire SM , Brockman AA , Earl D , Ihrie RA , Irish JM , Bachmann BO , Sulikowski GA , The use of fluorescently-tagged apoptolidins in cellular uptake and response studies. The Journal of antibiotics. 2016 Mar 9;
Surdel MC , Dutter BF , Sulikowski GA , Skaar EP , Bacterial Nitric Oxide Synthase Is Required for the Staphylococcus aureus Response to Heme Stress. ACS infectious diseases. 2016 Aug 12; 2 (8). 572-8
Choby JE , Mike LA , Mashruwala AA , Dutter BF , Dunman PM , Sulikowski GA , Boyd JM , Skaar EP , A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus. Cell chemical biology. 2016 Nov 17; 23 (11). 1351-1361
Wenzler E , Sulikowski A , An unexpected effect of acetal stereochemistry on the course of its reductive cleavage Tetrahedron Letters. 2016 Jul 27; 30 (57). 3254-55
Wenzler E , Melacon , Sulikowski A , A concise Diels-Alder strategy leading to congeners of the ABC ring system of the marine alkaloid ‘upenamide Tetrahedron Letters. 2016 Jul 27; 27 (30). 3252-3
Skaar P , Surdel , Sulikowski A , Dutter , Reid , Waterson Alex , Methods for use of small molecule activators of hem-y / protoporphyrinogen oxidase (ppo) United States Patent Application Publication. 2016 Jul 29; 62
Zweibel J , Romaine M , Ochieng , Waterson G , Sulikowski A , Binary compositions as disruptors of ORco-mediated odorant sensing The International Patent System. 2016 Sep 29; 111

2015

Williams CH , Hempel JE , Hao J , Frist AY , Williams MM , Fleming JT , Sulikowski GA , Cooper MK , Chiang C , Hong CC , An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell reports. 2015 Apr 7; 11 (1). 43-50
DeGuire SM , Earl DC , Du Y , Crews BA , Jacobs AT , Ustione A , Daniel C , Chong KM , Marnett LJ , Piston DW , Bachmann BO , Sulikowski GA , Fluorescent Probes of the Apoptolidins and their Utility in Cellular Localization Studies. Angewandte Chemie (International ed. in English). 2015 Jan 12; 54 (3). 961-4
Senter Timothy J , O'Reilly Matthew C , Chong Katherine M , Sulikowski Gary A , Lindsley Craig W , A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidines via organocatalysis Tetrahedron Letters. 2015 ; 56 1276-79
Romaine IM , Sulikowski GA , Studies on a biomimetic oxidative dimerization approach to the hibarimicins. Tetrahedron letters. 2015 Jun 3; 56 (23). 3617-3619
Du Y , Days E , Romaine I , Abney KK , Kaufmann K , Sulikowski G , Stauffer S , Lindsley CW , Weaver CD , Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. ACS chemical neuroscience. 2015 Jun 17; 6 (6). 871-8

2014

Hempel E , Engers W , Sulikowski A , Synthetic studies directed toward the AB decalin common to HMP-Y1 and hibarimicinone Tetrahedron Letters. 2014 ; 55 2157–2159
Evans SM , Kim K , Moore CE , Uddin MI , Capozzi ME , Craft JR , Sulikowski GA , Jayagopal A , Molecular probes for imaging of hypoxia in the retina. Bioconjugate chemistry. 2014 Nov 19; 25 (11). 2030-7
Romaine IM , Taylor RW , Saidu SP , Kim K , Sulikowski GA , Zwiebel LJ , Waterson AG , Narrow SAR in odorant sensing Orco receptor agonists. Bioorganic & medicinal chemistry letters. 2014 Jun 15; 24 (12). 2613-6
Mike LA , Choby JE , Brinkman PR , Olive LQ , Dutter BF , Ivan SJ , Gibbs CM , Sulikowski GA , Stauff DL , Skaar EP , Two-component system cross-regulation integrates Bacillus anthracis response to heme and cell envelope stress. PLoS pathogens. 2014 Mar ; 10 (3). e1004044

2013

Townsend SD , Sulikowski GA , Progress toward the total synthesis of bielschowskysin. Organic letters. 2013 Oct 4; 15 (19). 5096-8
Thompson MK , Keithly ME , Harp J , Cook PD , Jagessar KL , Sulikowski GA , Armstrong RN , Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus. Biochemistry. 2013 Oct 15; 52 (41). 7350-62
Ramos-Hunter SJ , Engers DW , Kaufmann K , Du Y , Lindsley CW , Weaver CD , Sulikowski GA , Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorganic & medicinal chemistry letters. 2013 Sep 15; 23 (18). 5195-8
Wen W , Wu W , Romaine IM , Kaufmann K , Du Y , Sulikowski GA , Weaver CD , Lindsley CW , Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorganic & medicinal chemistry letters. 2013 Aug 15; 23 (16). 4562-6
Soeiro Mde N , de Souza EM , da Silva CF , Batista Dda G , Batista MM , Pavão BP , Araújo JS , Aiub CA , da Silva PB , Lionel J , Britto C , Kim K , Sulikowski G , Hargrove TY , Waterman MR , Lepesheva GI , In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi. Antimicrobial agents and chemotherapy. 2013 Sep ; 57 (9). 4151-63
Kaufmann K , Romaine I , Days E , Pascual C , Malik A , Yang L , Zou B , Du Y , Sliwoski G , Morrison RD , Denton J , Niswender CM , Daniels JS , Sulikowski GA , Xie XS , Lindsley CW , Weaver CD , ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS chemical neuroscience. 2013 Sep 18; 4 (9). 1278-86
Mike LA , Dutter BF , Stauff DL , Moore JL , Vitko NP , Aranmolate O , Kehl-Fie TE , Sullivan S , Reid PR , DuBois JL , Richardson AR , Caprioli RM , Sulikowski GA , Skaar EP , Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 2013 May 14; 110 (20). 8206-11

2012

Hargrove TY , Kim K , de Nazaré Correia Soeiro M , da Silva CF , Batista DD , Batista MM , Yazlovitskaya EM , Waterman MR , Sulikowski GA , Lepesheva GI , CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds. International journal for parasitology, drugs and drug resistance. 2012 Dec ; 2 178-186
Liedtke AJ , Kim K , Stec DF , Sulikowski GA , Marnett LJ , Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up. Tetrahedron. 2012 Dec 2; 68 (48). 10049-10058
Lamers AP , Keithly ME , Kim K , Cook PD , Stec DF , Hines KM , Sulikowski GA , Armstrong RN , Synthesis of bacillithiol and the catalytic selectivity of FosB-type fosfomycin resistance proteins. Organic letters. 2012 Oct 19; 14 (20). 5207-9
Taylor RW , Romaine IM , Liu C , Murthi P , Jones PL , Waterson AG , Sulikowski GA , Zwiebel LJ , Structure-activity relationship of a broad-spectrum insect odorant receptor agonist. ACS chemical biology. 2012 Oct 19; 7 (10). 1647-52
Baranczak A , Sulikowski GA , Cascade assembly of the benzo[a]anthraquinone ring system common to the angucycline antibiotics. Tetrahedron letters. 2012 Mar 14; 53 (11). 1345-1346
Baranczak A , Sulikowski GA , Synthetic studies directed toward dideoxy lomaiviticinone lead to unexpected 1,2-oxazepine and isoxazole formation. Organic letters. 2012 Feb 17; 14 (4). 1027-9
Jones PL , Pask GM , Romaine IM , Taylor RW , Reid PR , Waterson AG , Sulikowski GA , Zwiebel LJ , Allosteric antagonism of insect odorant receptor ion channels. PloS one. 2012 ; 7 (1). e30304
Melancon BJ , Lamers AP , Bridges TM , Sulikowski GA , Utley TJ , Sheffler DJ , Noetzel MJ , Morrison RD , Daniels JS , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Wood MR , Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012. Bioorganic & medicinal chemistry letters. 2012 Jan 15; 22 (2). 1044-8

2011

Pyburn TM , Bensing BA , Xiong YQ , Melancon BJ , Tomasiak TM , Ward NJ , Yankovskaya V , Oliver KM , Cecchini G , Sulikowski GA , Tyska MJ , Sullam PM , Iverson TM , A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. PLoS pathogens. 2011 Jul ; 7 (7). e1002112
Chau ST , Hayakawa Y , Sulikowski GA , 18O assisted analysis of a γ,δ-epoxyketone cyclization: synthesis of the C16-C28 fragment of ammocidin D. Organic letters. 2011 Feb 18; 13 (4). 756-9
DeGuire SM , Ma S , Sulikowski GA , Synthesis of a bicyclobutane fatty acid identified from the cyanobacterium Anabaena PCC 7120. Angewandte Chemie (International ed. in English). 2011 Oct 10; 50 (42). 9940-2
Du Y , Derewacz DK , Deguire SM , Teske J , Ravel J , Sulikowski GA , Bachmann BO , Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40. Tetrahedron. 2011 Sep 2; 67 (35). 6568-6575
Romaine IM , Hempel JE , Shanmugam G , Hori H , Igarashi Y , Polavarapu PL , Sulikowski GA , Assignment and stereocontrol of hibarimicin atropoisomers. Organic letters. 2011 Sep 2; 13 (17). 4538-41

2010

Thorne CA , Hanson AJ , Schneider J , Tahinci E , Orton D , Cselenyi CS , Jernigan KK , Meyers KC , Hang BI , Waterson AG , Kim K , Melancon B , Ghidu VP , Sulikowski GA , LaFleur B , Salic A , Lee LA , Miller DM , Lee E , Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nature chemical biology. 2010 Nov ; 6 (11). 829-36
Bachmann BO , McNees R , Melancon BJ , Ghidu VP , Clark R , Crews BC , Deguire SM , Marnett LJ , Sulikowski GA , Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry. Organic letters. 2010 Jul 2; 12 (13). 2944-7
Smith BJ , Sulikowski GA , Total synthesis of (+/-)-haliclonacyclamine C. Angewandte Chemie (International ed. in English). 2010 Feb 22; 49 (9). 1599-602

2009

Daniels RN , Melancon BJ , Wang EA , Crews BC , Marnett LJ , Sulikowski GA , Lindsley CW , Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A. The Journal of organic chemistry. 2009 Nov 20; 74 (22). 8852-5
Baranczak A , Sulikowski GA , Chirality relay to access oxygenated angular aromatic polyketides. Angewandte Chemie (International ed. in English). 2009 ; 48 (33). 6005-7
Ghidu VP , Ntai I , Wang J , Jacobs AT , Marnett LJ , Bachmann BO , Sulikowski GA , Combined chemical and biosynthetic route to access a new apoptolidin congener. Organic letters. 2009 Jul 16; 11 (14). 3032-4
Walters MJ , Blobaum AL , Kingsley PJ , Felts AS , Sulikowski GA , Marnett LJ , The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives. Bioorganic & medicinal chemistry letters. 2009 Jun 15; 19 (12). 3271-4
Engers DW , Rodriguez AL , Williams R , Hammond AS , Venable D , Oluwatola O , Sulikowski GA , Conn PJ , Lindsley CW , Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr ; 4 (4). 505-11

2008

Kim K , Miller NR , Sulikowski GA , Lindsley CW , A new multi-gram synthetic route to labeling precursors for the D(2/3) PET agent 18F-fallypride. Bioorganic & medicinal chemistry letters. 2008 Aug 15; 18 (16). 4467-9
Ghidu VP , Wang J , Wu B , Liu Q , Jacobs A , Marnett LJ , Sulikowski GA , Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D. The Journal of organic chemistry. 2008 Jul 4; 73 (13). 4949-55
Zhang W , Baranczak A , Sulikowski GA , Stereocontrolled assembly of the C3/C3′ dideoxy core of lomaiviticin A/B and congeners. Organic letters. 2008 May 15; 10 (10). 1939-41

2007

Luo Z , Peplowski K , Sulikowski GA , Formation of the BC ring system of upenamide via a Staudinger/aza-Wittig reaction. Organic letters. 2007 Nov 22; 9 (24). 5051-4