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Publications

2019

Williams Jade C., Sheldon Jessica R., Imlay Hunter D., Dutter Brendan F., Draelos Matthew M., Skaar Eric P., Sulikowski Gary A., Synthesis of the Siderophore Coelichelin and Its Utility as a Probe in the Study of Bacterial Metal Sensing and Response Organic Letters. 2019 Jan 15; ASAP

2018

Yamanashi H., Boeglin W.E., Morisseau C., Davis R.W., Sulikowski G.S., Hammock B.D., Brash A.R., Catalytic activities of mammalian epoxide hydrolases with cis and trans fatty acid epoxides relevant to skin barrier function. J Lipid Res.. 2018 Feb 19; 4 (59) 684-695
Abney A.A., Ramos-Hunter S.J., Romaine I.M., Goodwin J.S., Sulikowski G.A., Weaver C.D., Selective Activation of N,N’-Diacyl Rhodamine Pro-fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE). Chemistry. 2018 May 25; 36 (24) 8985-8988
Dutter B.F., Ender A., Sulikowski G.A., Weaver C.D., Rhodol-based thallium sensors for cellular imaging of potassium channel activity. Org. Biomol. Chem.. 2018 Aug 8; 31 (16) 5575-5579
Boer R.E., Giménez-Bastida J.A., Boutaud O., Jana S., Schneider C., Sulikowski G.A., Total Synthesis and Biological Activity of the Arachidonic Acid Metabolite Hemiketal E2 Org. Lett.. 2018 Jun 19; 13 (20) 4020-4022

2017

Lepesheva G, Christov P, Sulikowski GA, Kim K, A convergent, scalable and stereoselective synthesis of azole CYP51 inhibitors. Tetrahedron letters. 2017 Nov 8; 58 (45) 4248-4250
Surdel MC, Horvath DJ, Lojek LJ, Fullen AR, Simpson J, Dutter BF, Salleng KJ, Ford JB, Jenkins JL, Nagarajan R, Teixeira PL, Albertolle M, Georgiev IS, Jansen ED, Sulikowski GA, Lacy DB, Dailey HA, Skaar EP, Antibacterial photosensitization through activation of coproporphyrinogen oxidase. Proceedings of the National Academy of Sciences of the United States of America. 2017 Aug 8; 114 (32) E6652-E6659
Rai G, Brimacombe KR, Mott BT, Urban DJ, Hu X, Yang SM, Lee TD, Cheff DM, Kouznetsova J, Benavides GA, Pohida K, Kuenstner EJ, Luci DK, Lukacs CM, Davies DR, Dranow DM, Zhu H, Sulikowski G, Moore WJ, Stott GM, Flint AJ, Hall MD, Darley-Usmar VM, Neckers LM, Dang CV, Waterson AG, Simeonov A, Jadhav A, Maloney DJ, Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). Journal of medicinal chemistry. 2017 Nov 22; 60 (22) 9184-9204
Azumaya CM, Days EL, Vinson PN, Stauffer S, Sulikowski G, Weaver CD, Nakagawa T, Screening for AMPA receptor auxiliary subunit specific modulators. PloS one. 2017 12 (3) e0174742

2016

Wenzler E, Sulikowski A, An unexpected effect of acetal stereochemistry on the course of its reductive cleavage Tetrahedron Letters. 2016 Jul 27; 30 (57) 3254-55
Dutter BF, Mike LA, Reid PR, Chong KM, Ramos-Hunter SJ, Skaar EP, Sulikowski GA, Decoupling Activation of Heme Biosynthesis from Anaerobic Toxicity in a Molecule Active in Staphylococcus aureus. ACS chemical biology. 2016 Mar 4;
Chong KM, Leelatian N, Deguire SM, Brockman AA, Earl D, Ihrie RA, Irish JM, Bachmann BO, Sulikowski GA, The use of fluorescently-tagged apoptolidins in cellular uptake and response studies. The Journal of antibiotics. 2016 Mar 9;
Surdel MC, Dutter BF, Sulikowski GA, Skaar EP, Bacterial Nitric Oxide Synthase Is Required for the Staphylococcus aureus Response to Heme Stress. ACS infectious diseases. 2016 Aug 12; 2 (8) 572-8
Choby JE, Mike LA, Mashruwala AA, Dutter BF, Dunman PM, Sulikowski GA, Boyd JM, Skaar EP, A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus. Cell chemical biology. 2016 Nov 17; 23 (11) 1351-1361
Wenzler E, Melacon, Sulikowski A, A concise Diels-Alder strategy leading to congeners of the ABC ring system of the marine alkaloid ‘upenamide Tetrahedron Letters. 2016 Jul 27; 27 (30) 3252-3
Skaar P, Surdel, Sulikowski A, Dutter, Reid, Waterson Alex, Methods for use of small molecule activators of hem-y / protoporphyrinogen oxidase (ppo) United States Patent Application Publication. 2016 Jul 29; 62
Zweibel J, Romaine M, Ochieng, Waterson G, Sulikowski A, Binary compositions as disruptors of ORco-mediated odorant sensing The International Patent System. 2016 Sep 29; 111

2015

Williams CH, Hempel JE, Hao J, Frist AY, Williams MM, Fleming JT, Sulikowski GA, Cooper MK, Chiang C, Hong CC, An in vivo chemical genetic screen identifies phosphodiesterase 4 as a pharmacological target for hedgehog signaling inhibition. Cell reports. 2015 Apr 7; 11 (1) 43-50
Du Y, Days E, Romaine I, Abney KK, Kaufmann K, Sulikowski G, Stauffer S, Lindsley CW, Weaver CD, Development and validation of a thallium flux-based functional assay for the sodium channel NaV1.7 and its utility for lead discovery and compound profiling. ACS chemical neuroscience. 2015 Jun 17; 6 (6) 871-8
Romaine IM, Sulikowski GA, Studies on a biomimetic oxidative dimerization approach to the hibarimicins. Tetrahedron letters. 2015 Jun 3; 56 (23) 3617-3619
Senter Timothy J, O'Reilly Matthew C, Chong Katherine M, Sulikowski Gary A, Lindsley Craig W, A general, enantioselective synthesis of N-alkyl terminal aziridines and C2-functionalized azetidines via organocatalysis Tetrahedron Letters. 2015 56 1276-79
DeGuire SM, Earl DC, Du Y, Crews BA, Jacobs AT, Ustione A, Daniel C, Chong KM, Marnett LJ, Piston DW, Bachmann BO, Sulikowski GA, Fluorescent Probes of the Apoptolidins and their Utility in Cellular Localization Studies. Angewandte Chemie (International ed. in English). 2015 Jan 12; 54 (3) 961-4

2014

Evans SM, Kim K, Moore CE, Uddin MI, Capozzi ME, Craft JR, Sulikowski GA, Jayagopal A, Molecular probes for imaging of hypoxia in the retina. Bioconjugate chemistry. 2014 Nov 19; 25 (11) 2030-7
Hempel E, Engers W, Sulikowski A, Synthetic studies directed toward the AB decalin common to HMP-Y1 and hibarimicinone Tetrahedron Letters. 2014 55 2157–2159
Mike LA, Choby JE, Brinkman PR, Olive LQ, Dutter BF, Ivan SJ, Gibbs CM, Sulikowski GA, Stauff DL, Skaar EP, Two-component system cross-regulation integrates Bacillus anthracis response to heme and cell envelope stress. PLoS pathogens. 2014 Mar 10 (3) e1004044
Romaine IM, Taylor RW, Saidu SP, Kim K, Sulikowski GA, Zwiebel LJ, Waterson AG, Narrow SAR in odorant sensing Orco receptor agonists. Bioorganic & medicinal chemistry letters. 2014 Jun 15; 24 (12) 2613-6

2013

Townsend SD, Sulikowski GA, Progress toward the total synthesis of bielschowskysin. Organic letters. 2013 Oct 4; 15 (19) 5096-8
Thompson MK, Keithly ME, Harp J, Cook PD, Jagessar KL, Sulikowski GA, Armstrong RN, Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus. Biochemistry. 2013 Oct 15; 52 (41) 7350-62
Ramos-Hunter SJ, Engers DW, Kaufmann K, Du Y, Lindsley CW, Weaver CD, Sulikowski GA, Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorganic & medicinal chemistry letters. 2013 Sep 15; 23 (18) 5195-8
Wen W, Wu W, Romaine IM, Kaufmann K, Du Y, Sulikowski GA, Weaver CD, Lindsley CW, Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibitors. Bioorganic & medicinal chemistry letters. 2013 Aug 15; 23 (16) 4562-6
Soeiro Mde N, de Souza EM, da Silva CF, Batista Dda G, Batista MM, Pavão BP, Araújo JS, Aiub CA, da Silva PB, Lionel J, Britto C, Kim K, Sulikowski G, Hargrove TY, Waterman MR, Lepesheva GI, In vitro and in vivo studies of the antiparasitic activity of sterol 14α-demethylase (CYP51) inhibitor VNI against drug-resistant strains of Trypanosoma cruzi. Antimicrobial agents and chemotherapy. 2013 Sep 57 (9) 4151-63
Kaufmann K, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD, ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice. ACS chemical neuroscience. 2013 Sep 18; 4 (9) 1278-86
Mike LA, Dutter BF, Stauff DL, Moore JL, Vitko NP, Aranmolate O, Kehl-Fie TE, Sullivan S, Reid PR, DuBois JL, Richardson AR, Caprioli RM, Sulikowski GA, Skaar EP, Activation of heme biosynthesis by a small molecule that is toxic to fermenting Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America. 2013 May 14; 110 (20) 8206-11

2012

Jones PL, Pask GM, Romaine IM, Taylor RW, Reid PR, Waterson AG, Sulikowski GA, Zwiebel LJ, Allosteric antagonism of insect odorant receptor ion channels. PloS one. 2012 7 (1) e30304
Melancon BJ, Lamers AP, Bridges TM, Sulikowski GA, Utley TJ, Sheffler DJ, Noetzel MJ, Morrison RD, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Wood MR, Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012. Bioorganic & medicinal chemistry letters. 2012 Jan 15; 22 (2) 1044-8
Baranczak A, Sulikowski GA, Synthetic studies directed toward dideoxy lomaiviticinone lead to unexpected 1,2-oxazepine and isoxazole formation. Organic letters. 2012 Feb 17; 14 (4) 1027-9
Baranczak A, Sulikowski GA, Cascade assembly of the benzo[a]anthraquinone ring system common to the angucycline antibiotics. Tetrahedron letters. 2012 Mar 14; 53 (11) 1345-1346
Taylor RW, Romaine IM, Liu C, Murthi P, Jones PL, Waterson AG, Sulikowski GA, Zwiebel LJ, Structure-activity relationship of a broad-spectrum insect odorant receptor agonist. ACS chemical biology. 2012 Oct 19; 7 (10) 1647-52
Lamers AP, Keithly ME, Kim K, Cook PD, Stec DF, Hines KM, Sulikowski GA, Armstrong RN, Synthesis of bacillithiol and the catalytic selectivity of FosB-type fosfomycin resistance proteins. Organic letters. 2012 Oct 19; 14 (20) 5207-9
Liedtke AJ, Kim K, Stec DF, Sulikowski GA, Marnett LJ, Straightforward protocol for the efficient synthesis of varied N(1)-acylated (aza)indole 2-/3-alkanoic acids and esters: optimization and scale-up. Tetrahedron. 2012 Dec 2; 68 (48) 10049-10058
Hargrove TY, Kim K, de Nazaré Correia Soeiro M, da Silva CF, Batista DD, Batista MM, Yazlovitskaya EM, Waterman MR, Sulikowski GA, Lepesheva GI, CYP51 structures and structure-based development of novel, pathogen-specific inhibitory scaffolds. International journal for parasitology, drugs and drug resistance. 2012 Dec 2 178-186

2011

Pyburn TM, Bensing BA, Xiong YQ, Melancon BJ, Tomasiak TM, Ward NJ, Yankovskaya V, Oliver KM, Cecchini G, Sulikowski GA, Tyska MJ, Sullam PM, Iverson TM, A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. PLoS pathogens. 2011 Jul 7 (7) e1002112
Chau ST, Hayakawa Y, Sulikowski GA, 18O assisted analysis of a γ,δ-epoxyketone cyclization: synthesis of the C16-C28 fragment of ammocidin D. Organic letters. 2011 Feb 18; 13 (4) 756-9
DeGuire SM, Ma S, Sulikowski GA, Synthesis of a bicyclobutane fatty acid identified from the cyanobacterium Anabaena PCC 7120. Angewandte Chemie (International ed. in English). 2011 Oct 10; 50 (42) 9940-2
Du Y, Derewacz DK, Deguire SM, Teske J, Ravel J, Sulikowski GA, Bachmann BO, Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40. Tetrahedron. 2011 Sep 2; 67 (35) 6568-6575
Romaine IM, Hempel JE, Shanmugam G, Hori H, Igarashi Y, Polavarapu PL, Sulikowski GA, Assignment and stereocontrol of hibarimicin atropoisomers. Organic letters. 2011 Sep 2; 13 (17) 4538-41

2010

Thorne CA, Hanson AJ, Schneider J, Tahinci E, Orton D, Cselenyi CS, Jernigan KK, Meyers KC, Hang BI, Waterson AG, Kim K, Melancon B, Ghidu VP, Sulikowski GA, LaFleur B, Salic A, Lee LA, Miller DM, Lee E, Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α. Nature chemical biology. 2010 Nov 6 (11) 829-36
Bachmann BO, McNees R, Melancon BJ, Ghidu VP, Clark R, Crews BC, Deguire SM, Marnett LJ, Sulikowski GA, Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry. Organic letters. 2010 Jul 2; 12 (13) 2944-7
Smith BJ, Sulikowski GA, Total synthesis of (+/-)-haliclonacyclamine C. Angewandte Chemie (International ed. in English). 2010 Feb 22; 49 (9) 1599-602

2009

Daniels RN, Melancon BJ, Wang EA, Crews BC, Marnett LJ, Sulikowski GA, Lindsley CW, Progress toward the total synthesis of lucentamycin A: total synthesis and biological evaluation of 8-epi-lucentamycin A. The Journal of organic chemistry. 2009 Nov 20; 74 (22) 8852-5
Engers DW, Rodriguez AL, Williams R, Hammond AS, Venable D, Oluwatola O, Sulikowski GA, Conn PJ, Lindsley CW, Synthesis, SAR and unanticipated pharmacological profiles of analogues of the mGluR5 ago-potentiator ADX-47273. ChemMedChem. 2009 Apr 4 (4) 505-11
Walters MJ, Blobaum AL, Kingsley PJ, Felts AS, Sulikowski GA, Marnett LJ, The influence of double bond geometry in the inhibition of cyclooxygenases by sulindac derivatives. Bioorganic & medicinal chemistry letters. 2009 Jun 15; 19 (12) 3271-4
Ghidu VP, Ntai I, Wang J, Jacobs AT, Marnett LJ, Bachmann BO, Sulikowski GA, Combined chemical and biosynthetic route to access a new apoptolidin congener. Organic letters. 2009 Jul 16; 11 (14) 3032-4
Baranczak A, Sulikowski GA, Chirality relay to access oxygenated angular aromatic polyketides. Angewandte Chemie (International ed. in English). 2009 48 (33) 6005-7

2008

Zhang W, Baranczak A, Sulikowski GA, Stereocontrolled assembly of the C3/C3′ dideoxy core of lomaiviticin A/B and congeners. Organic letters. 2008 May 15; 10 (10) 1939-41
Ghidu VP, Wang J, Wu B, Liu Q, Jacobs A, Marnett LJ, Sulikowski GA, Synthesis and evaluation of the cytotoxicity of apoptolidinones A and D. The Journal of organic chemistry. 2008 Jul 4; 73 (13) 4949-55
Kim K, Miller NR, Sulikowski GA, Lindsley CW, A new multi-gram synthetic route to labeling precursors for the D(2/3) PET agent 18F-fallypride. Bioorganic & medicinal chemistry letters. 2008 Aug 15; 18 (16) 4467-9

2007

Luo Z, Peplowski K, Sulikowski GA, Formation of the BC ring system of upenamide via a Staudinger/aza-Wittig reaction. Organic letters. 2007 Nov 22; 9 (24) 5051-4