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Circadian Clocks: Unexpected Biochemical Cogs.


Mori TTetsuya , Mchaourab H Hassane , Johnson CH Carl Hirschie . Current biology : CB. 2015 10 5; 25(19). R842-4


A circadian oscillation can be reconstituted in vitro from three proteins that cycles with a period of ∼ 24 h. Two recent studies provide surprising biochemical answers to why this remarkable oscillator has such a long time constant and how it can switch effortlessly between alternating enzymatic modes.