Circadian Clocks: Unexpected Biochemical Cogs.
AUTHORS
Mori
TTetsuya ,
Mchaourab
H Hassane ,
Johnson
CH Carl Hirschie .
Current biology : CB. 2015 10 5; 25(19).
R842-4
- PMID: 26439342[PubMed].
- PMCID: PMC4697453.
- NIHMSID: NIHMS744952
ABSTRACT
A circadian oscillation can be reconstituted in vitro from three proteins that cycles with a period of ∼ 24 h. Two recent studies provide surprising biochemical answers to why this remarkable oscillator has such a long time constant and how it can switch effortlessly between alternating enzymatic modes.