Skip to main content

Hamm Lab

Hamm Lab Publications

2024

Erreger Kevin , Cao Shirong , Pan Yu , Jiang Mengdi , Zhang Ming-Zhi , Harris C , Hamm E , Role of protease-activated receptor 4 in mouse models of acute and chronic kidney injury Americal Journal of Physiology: Renal Physiology. 2024 Feb 1; 326 (2). F219-F226
Smith T , Cassada B , Bredow Von , Erreger Kevin , Webb M , Trombley A , Kalbfleisch J , Bender J , Zagol-Ikapitte Irene , Kramlinger M , Bouchard L , Mitchell G , Tretbar Maik , Shoichet K , Lindsley W , Meiler Jens , Hamm E , Discovery of Protease-Activated Receptor 4 (PAR4)-Tethered Ligand Antagonists Using Ultralarge Virtual Screening ACS Pharmacology & Translational Science. 2024 Mar 21; 7 (4). 1086-1100
Winfree L , Erreger Kevin , Phillips Jared , Seta Mabel , Wang Yanling , Schneider A , Bennett A , Schrag S , Hohman J , Hamm E , Elevated protease-activated receptor 4 (PAR4) gene expression in Alzheimer’s disease predicts cognitive decline Neurobiology of Aging. 2024 Apr 21; 140 93-101

2023

Ceddia P , Zurawski Zack , Gray Thompson , Adegboye Feyisayo , McDonald-Boyer Ainsley , Shi Fubiao , Liu Dianxin , Maldonado Jose , Feng Jiesi , Li Yulong , Alford Simon , Ayala E , McGuinness P , Collins Sheila , Hamm E , Gβγ-SNAP25 exocytotic brake removal enhances insulin action, promotes adipocyte browning, and protects against diet-induced obesity The Journal of Clinical Investigation. 2023 Oct 2; 133 (19).
Manz M , Zepeda C , Zurawski E , Hamm E , Grueter A , SNAP25 differentially contributes to Gi/o-coupled receptor function at glutamatergic synapses in the nucleus accumbens Frontiers in Molecular Neuroscience. 2023 May 2; 17
Caruso Giovanni , Klaus Colin , Hamm E , Gurevich V , Bisegna Paolo , Andreucci Daniele , DiBenedetto Emmanuele , Makino L , Pepperberg plot: Modeling flash response saturation in retinal rods of mouse Frontiers in Molecular Neuroscience. 2023 Jan 13; 15

2022

Geva Polina , Caruso Giovanni , Klaus Colin , Hamm E , Gurevich V , DiBenedetto Emmanuele , Makino L , Effects of cell size and bicarbonate on single photon response variability in retinal rods Frontiers in Molecular Neuroscience. 2022 Dec 14; 15
Alten Baris , Guzikowski Natalie , Zurawski Zack , Hamm HE , Kavalali Ege , Presynaptic mechanisms underlying GABA B-receptor-mediated inhibition of spontaneous neurotransmitter release Cell Reports. 2022 Jan 18; 38 (3). 110255

2021

Berton Jeanette , Duvernay MT , Mitchell Sidnee , Smith Shannon , Maeng Jae , Blobaum Anna , Davis Dexter , Meiler Jens , Hamm HE , Lindsley Craig , Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors ACS Chemical Neuroscience. 2021 Dec 15; 24 (12). 4524-4534
Yim YY , McDonald WH , Betke KM , Kaya A , Hyde K , Erreger K , Gilsback R , Hein L , Hamm HE , Specificities of Gβγ subunits for the SNARE complex before and after stimulation of α2a-adrenergic receptors. Science Signaling. 2021 Dec 21; 14 (714). 4670

2020

Werfel Thomas , Hicks Donna , Rahman Bushra , Bendeman Wendy , Duvernay MT , Maeng Jae , Hamm HE , Lavieri Robert , Joly Meghan , Pulley Jill , Elion David , Brantley-Sieders Dana , Cook Rebecca , Repurposing of a Thromboxane Receptor Inhibitor Based on a Novel Role in Metastasis Identified by Phenome-Wide Association Study Molecular Cancer Therapeutics. 2020 Oct 8; 19 (12). 2454-2464
Caruso G , Klaus CJ , Hamm HE , Gurevich VV , Makino CL , DiBenedetto E , Position of rhodopsin photoisomerization on the disk surface confers variability to the rising phase of the single photon response in vertebrate rod photoreceptors. PLoS One. 2020 Oct 14; 15 (10). 240527
Thompson Gray AD , Simonettie J , Adegboye F , Jones CK , Zurawski Z , Hamm HE , Sexual Dimorphism in Stress-induced Hyperthermia in SNAP25Δ3 mice, a mouse model with disabled Gβγ regulation of the exocytotic fusion apparatus European Journal of Neuroscience. 2020 Jul ; 52 (1). 2815-2829
Yim YY , Betke KM , McDonald WH , Gilsbach R , Chen Y , Hyde K , Wang Q , Hein L , Hamm HE , The in vivo specificity of synaptic Gβ and Gγ subunits to the α 2a adrenergic receptor at CNS synapses Scientific Reports - Nature. 2020 Feb 14; 1 (10). 2966
Hamm HE , Alford ST , Physiological roles for neuromodulation via Gi/o GPCRs working through Gβγ-SNARE interaction. Neuropsychopharmacology. 2020 Jan ; 45 (1). 221

2019

Manz KM , Baxley AG , Zurawski Z , Hamm HE , Grueter BA , Heterosynaptic GABA B Receptor Function within Feedforward Microcircuits Gates Glutamatergic Transmission in the Nucleus Accumbens Core Journal of Neuroscience. 2019 Nov 20; 39 (47). 9277-9293
Irfan M , Zurawski Z , Hamm HE , Bark C , Bark PK , Disabling Gβγ-SNAP-25 interaction in gene-targeted mice results in enhancement of long-term potentiation at Schaffer collateral-CA1 synapses in the hippocampus. Science Signaling. 2019 Jul 3; 10 (30). 695-699
Zurawski Z , Thompson Gray AD , Brady AJ , Page B , Church E , Harris NA , Dohn MR , Yim YY , Hyde K , Mortlock DP , Jones CK , Winder DG , Alford S , Hamm HE , Disabling the Gβγ-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes Science Signaling. 2019 Feb 19; 12 (596). 8595
Yim YY , Betke KM , McDonald WH , Gilsbach R , Chen Y , Hyde K , Wang Q , Hein L , Hamm HE , The in vivo specificity of synaptic Gβ and Gγ subunits to the α2a adrenergic receptor at CNS synapses. Scientific Reports - Nature. 2019 Feb 8; 9 (1). 1718
Zurawski Z , Yim YY , Alfred S , Hamm HE , The expanding roles and mechanisms of G protein-mediated presynaptic inhibition. Journal of Biological Chemistry. 2019 Feb 1; 294 (5). 1661-1670
Rigg RA , Healy LD , Chu TT , Ngo ATP , Mitrugno A , Zilberman-Rudenko J , Aslan JE , Hinds MT , Vecchiarelli LD , Morgan TK , Gruber A , Temple KJ , Lindsley CW , Duvernay MT , Hamm HE , McCarty OTJ , Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions. Platelets. Platelets. 2019 ; 30 (1). 126-135
Mitrugno A , Hamm HE , Tassi Y , Sylman JL , Zilberman-Rudenko J , Shirai T , Hebert JF , Kayton R , Zhang Y , Nan X , Shatzel JJ , Esener S , Duvernay MT , Gruber A , Williams CD , Takata Y , Armstrong R , Morgan TK , McCarty OJT , The role of coagulation and platelets in colon cancer-associated thrombosis. American Journal of Physiology-Cell Physiology. 2019 ; 316 (2). 264-C273

2018

Lokits AD , Indrischek H , Meiler J , Hamm HE , Stadler PF , Tracing the evolution of the heterotrimeric G protein α subunit in Metazoa. BMC evolutionary biology. 2018 Apr 11; 18 (1). 51
Damian M , Pons V , Renault P , M'Kadmi C , Delort B , Hartmann L , Kaya AI , Louet M , Gagne D , Ben Haj Salah K , Denoyelle S , Ferry G , Boutin JA , Wagner R , Fehrentz JA , Martinez J , Marie J , Floquet N , Galès C , Mary S , Hamm HE , Banères JL , GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation. Proceedings of the National Academy of Sciences of the United States of America. 2018 Apr 24; 115 (17). 4501-4506
Kaiser A , Hempel C , Wanka L , Schubert M , Hamm HE , Beck-Sickinger AG , G Protein Preassembly Rescues Efficacy of W Toggle Mutations in Neuropeptide Y Receptor. Molecular pharmacology. 2018 Apr ; 93 (4). 387-401

2017

Duvernay MT , Temple KJ , Maeng JG , Blobaum AL , Stauffer SR , Lindsley CW , Hamm HE , Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation… Molecular Pharmacology. 2017 Jan ; 91 (1). 39-47
Schmidt P , Bender BJ , Kaiser A , Gulati K , Scheidt HA , Hamm HE , Meiler J , Beck-Sickinger AG , Huster D , Improved Folding of the Y G Protein-Coupled Receptor into Bicelles. Frontiers in molecular biosciences. 2017 ; 4 100
Yim YY , McDonald WH , Hyde K , Cruz-Rodríguez O , Tesmer JJG , Hamm HE , Quantitative Multiple-Reaction Monitoring Proteomic Analysis of Gβ and Gγ Subunits in C57Bl6/J Bra… Biochemistry. 2017 Dec 10; 56 (40). 5405-5416
Zurawski Z , Page B , Chicka MC , Brindley RL , Wells CA , Preininger AM , Hyde K , Gilbert JA , Cruz-Rodriguez O , Currie KPM , Chapman ER , Alford S , Hamm HE , Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNAR… The Journal of biological chemistry. 2017 Dec 21; 292 (29). 12165-12177
Van Hook MJ , Babai N , Zurawski Z , Yim YY , Hamm HE , Thoreson WB , A Presynaptic Group III mGluR Recruits Gβγ/SNARE Interactions to Inhibit Synaptic Transmission by … The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Apr 26; 37 (17). 4618-4634

2016

Temple KJ , Duvernay MT , Maeng JG , Blobaum AL , Stauffer SR , Hamm HE , Lindsley CW , Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy… Bioorganic & medicinal chemistry letters. 2016 Dec 15; 26 (22). 5481-5486
Temple KJ , Duvernay MT , Young SE , Wen W , Wu W , Maeng JG , Blobaum AL , Stauffer SR , Hamm HE , Lindsley CW , Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)… Journal of medicinal chemistry. 2016 Aug 25; 59 (16). 7690-5
Kaya AI , Lokits AD , Gilbert JA , Iverson TM , Meiler J , Hamm HE , A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Rece… The Journal of biological chemistry. 2016 Dec 9; 291 (37). 19674-86
Oliver KH , Duvernay MT , Hamm HE , Carneiro AM , Loss of Serotonin Transporter Function Alters ADP-mediated Glycoprotein αIIbβ3 Activation through … The Journal of biological chemistry. 2016 Dec 16; 291 (38). 20210-9
Gupta A , Gomes I , Bobeck EN , Fakira AK , Massaro NP , Sharma I , Cavé A , Hamm HE , Parello J , Devi LA , Collybolide is a novel biased agonist of κ-opioid receptors with potent antipruritic activity. Proceedings of the National Academy of Sciences of the United States of America. 2016 May 24; 113 (21). 6041-6
Zurawski Z , Rodriguez S , Hyde K , Alford S , Hamm HE , Gβγ Binds to the Extreme C Terminus of SNAP25 to Mediate the Action of Gi/o-Coupled G Protein-Coup… Molecular pharmacology. 2016 Jan ; 89 (1). 75-83
Friedman EA , Texeira L , Delaney J , Weeke PE , Lynch DR , Kasasbeh E , Song Y , Harrell FE , Denny JC , Hamm HE , Roden DM , Cleator JH , Evaluation of the F2R IVS-14A/T PAR1 polymorphism with subsequent cardiovascular events and bleeding… Journal of thrombosis and thrombolysis. 2016 May ; 41 (4). 656-62

2015

Duvernay MT , Matafonov A , Lindsley CW , Hamm HE , Platelet Lipidomic Profiling: Novel Insight into Cytosolic Phospholipase A2α Activity and Its Role … Biochemistry. 2015 Sep 15; 54 (36). 5578-88
Kaya AI , Iverson TM , Hamm HE , Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin … Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles.. 2015 ; 1271 67-76 Part III
Yim YY , Betke K , Hamm H , Using Peptide Arrays Created by the SPOT Method for Defining Protein-Protein Interactions. Methods in molecular biology (Clifton, N.J.). 2015 ; 1278 307-20
Young SE , Duvernay MT , Schulte ML , Nance KD , Melancon BJ , Engers J , Wood MR , Hamm HE , Lindsley CW , A Novel and Selective PAR4 Antagonist: ML354 2015 Feb 11;

2014

Jacobson R , Mignemi N , Rose K , O'Rear L , Sarilla S , Hamm HE , Barnett JV , Verhamme IM , Schoenecker J , The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction … Thrombosis research. 2014 Dec ; 134 (6). 1350-7
Alexander NS , Preininger AM , Kaya AI , Stein RA , Hamm HE , Meiler J , Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release. Nature Structural Molecular Biology. 2014 Jan ; 21 (1). 56-63
Hamid E , Church E , Wells CA , Zurawski Z , Hamm HE , Alford S , Modulation of neurotransmission by GPCRs is dependent upon the microarchitecture of the primed vesic… Journal of Neuroscience. 2014 Jan 1; 1 (34). 260-74
Betke KM , Rose KL , Friedman DB , Baucum AJ , Hyde K , Shey KL , Hamm HE , Differential localization of G protein βγ subunits. Biochemistry. 2014 Apr 15; 14 (53). 2329-43
Thaker TM , Sarwar M , Preininger AM , Hamm HE , Iverson TM , A transient interaction between the phosphate binding loop and switch I contributes to the allosteri… Journal of Biological Chemistry. 2014 Apr 18; 16 (289). 11331-41
Kaya AI , Lokits AD , Gilbert JA , Iverson TM , Hamm HE , A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrime… 2014 Aug 29; 289 (35). 24475-87
Cleator JH , Duvernay MT , Holinstat M , Hudson WJ , Song Y , Harrell FE , Hamm HE , Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. The Journal of Pharmacology and Experimental Therapeutics. 2014 Oct ; 35 (1). 33-43
Wen W , Young SE , Duvernay MT , Schulte ML , Nance KD , Melancon BJ , Engers J , Locuson CW 2nd , Wood MR , Daniels JS , Wu W , Lindsley CW , Hamm HE , Stauffer SR , Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SA… Bioorganic & Medicinal Chemistry Letters. 2014 Oct 1; 24 (19). 4708-13
Jacobson R , Mignemi N , Rose K , O'Rear L , Sarilla S , Hamm HE , Barnett JV , Verhamme IM , Schoenecker J , The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction … Thrombosis Research. 2014 Dec ; 134 (6). 1350-7

2013

Young SE , Duvernay MT , Schulte ML , Lindsley CW , Hamm HE , Synthesis of indole derived protease-activated receptor 4 antagonists and characterization in human … PLoS One. 2013 Jun 11; 8 (6). e65528.
Li X , Roszko I , Sepich DS , Ni M , Hamm HE , Marlow FL , Solnica-Krezel L , Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development. 2013 Jul ; 140 (14). 3028-39
Holinstat M , Colowick NE , Hudson WJ , Blakemore D , Chen Q , Hamm HE , Cleator JH , Dichotomous effects of exposure to bivalirudin in patients undergoing percutaneous coronary interven… Journal of Thrombosis and Thrombolysis. 2013 Feb ; 35 (2). 209-22
Natarajan C , HATA AN , Hamm HE , Zent R , Breyer RM , Extracellular loop II modulates GTP sensitivity of the prostaglandin EP3 receptor. Molecular Pharmacology. 2013 Jan ; 83 (1). 206-16
Duvernay M , Young S , Gailani D , Schoenecker J , Hamm HE , Protease-activated receptor (PAR) 1 and PAR4 differentially regulate factor V expression from human … Molecular Pharmacology. 2013 Apr ; 83 (4). 781-92
Hamm HE , Kaya AI , Gilbert JA , Preininger AM , Linking receptor activation to changes in Sw I and II of Gα proteins. Journal of Structural Biology. 2013 Oct ; 184 (1). 63-74
Preininger AM , Meiler J , Hamm HE , Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspect… Journal of Molecular Biology. 2013 Jul 10; 425 (13). 2288-98

2012

Thaker TM , Kaya AI , Prieninger AM , Hamm HE , Iverson TM , Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective. 2012 ; 796 133-174
O'Neill KR , Stutz CM , Mignemi NA , Cole H , Murray MR , Nyman JS , Hamm H , Shoenecker JG , Fracture healing in protease-activated receptor-2 deficient mice. J. Orthop. Res.. 2012 Jan 13; 30 (8). 1271-6
Betke Katherine , Wells Christopher A. , Hamm Heidi E. , GPCR mediated regulation of synaptic transmission. Progress in Neurobiology. 2012 Mar ; 96 (3). 304-21
Preininger AM , Kaya AI , Gilbert JA , Busenlehner LS , Armstrong RN , Hamm HE , Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution. Biochemistry. 2012 Mar 6; 51 (9). 1911-24
wELLS CA , Betke KM , Lindsley CW , Hamm HE , Label-free detection of G protein-SNARE interactions and screening for small molecule modulators. ACS Chemical Neuroscience. 2012 Jan 18; 3 (1).
Makino CL , Wen XH , Michaud NA , Covington HI , DiBenedetto E , Hamm HE , Lem J , Caruso G , Rhodopsin expression level affects rod outer segment morphology and photoresponse kinetics. PLoS One. 2012 May 25; 7 (5). e37832
Wells CA , Zurawski Z , Betke KM , Yim YY , Hyde K , Rodriquez S , Alford S , Hamm HE , Gβγ inhibits exocytosis via interaction with critical residues on soluble N-ethylmaleimide-sensiti… Molecular Pharmacology. 2012 Dec ; 82 (6). 1136-49
Ichikawa J , Cole HA , Magnussen RA , Mignemi NA , Butler M , Holt GE , O'Rear L , Yuasa M , Pabla B , Haro H , Cates JM , Hamm HE , Schwartz HS , Schoenecker JG , Thrombin induces osteosarcoma growth, a function inhibited by low molecular weight heparin in vitro … Cancer. 2012 May 1; 118 (9). 2494-506

2011

Lenoci L , Duvernay M , Satchell S , DiBenedetto E , Hamm HE , Mathematical model of PAR1-mediated activation of human platelets. Molecular Biosystems. 2011 Apr ; 7 (4). 1129-37
Kaya AI , Thaker TM , Preininger AM , Iverson TM , Hamm HE , Coupling efficiency of rhodopsin and transducin in bicelles. Biochemistry. 2011 Apr 19; 50 (15). 3193-203
Van Eps N , Preininger AM , Alexander N , Kaya AI , Meier S , Meiler J , Hamm HE , Hubbell WL , Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha s… Proceedings of the National Academy of Sciences of the United States of America. 2011 Jun 7; 108 (23). 9420-4
Caruso G , Bisegna P , Andreucci D , Lenoci L , Gurevich VV , Hamm HE , DiBenedetto E , Identification of key factors that reduce the variability of the single photon response. Proceedings of the National Academy of Sciences of the United States of America. 2011 May 10; 108 (19). 7804-7
Holinstat M , Boutaud O , Apopa PL , Vesci J , Bala M , Oates JA , Hamm HE , Protease-activated receptor signaling in platelets activates cytosolic phospholipase A2α differentl… Arteriosclerosis, thrombosis, and vascular biology. 2011 Feb ; 31 (2). 435-42

2010

Jernigan KK , Cselenyi CS , Thorne CA , Hanson AJ , Tahinci E , Hajicek N , Oldham WM , Lee LA , Hamm HE , Hepler JR , Kozasa T , Linder ME , Lee E , Gbetagamma activates GSK3 to promote LRP6-mediated beta-catenin transcriptional activity. Science signaling. 2010 ; 3 (121). ra37
Shen L , Caruso G , Bisegna P , Andreucci D , Gurevich VV , Hamm HE , DiBenedetto E , Dynamics of mouse rod phototransduction and its sensitivity to variation of key parameters. IET systems biology. 2010 Jan ; 4 (1). 12-32
Caruso G , Bisegna P , Lenoci L , Andreucci D , Gurevich VV , Hamm HE , DiBenedetto E , Kinetics of rhodopsin deactivation and its role in regulating recovery and reproducibility of rod ph… PLoS computational biology. 2010 ; 6 (12). e1001031

2009

Marjoram RJ , Voss B , Pan Y , Dickeson SK , Zutter MM , Hamm HE , Santoro SA , Suboptimal activation of protease-activated receptors enhances alpha2beta1 integrin-mediated platele… The Journal of biological chemistry. 2009 Dec 11; 284 (50). 34640-7
Wen XH , Shen L , Brush RS , Michaud N , Al-Ubaidi MR , Gurevich VV , Hamm HE , Lem J , Dibenedetto E , Anderson RE , Makino CL , Overexpression of rhodopsin alters the structure and photoresponse of rod photoreceptors. Biophysical journal. 2009 Feb ; 96 (3). 939-50
Preininger AM , Funk MA , Oldham WM , Meier SM , Johnston CA , Adhikary S , Kimple AJ , Siderovski DP , Hamm HE , Iverson TM , Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai… Biochemistry. 2009 Mar 31; 48 (12). 2630-42
Hamm HE , Meier SM , Liao G , Preininger AM , Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Ga… Protein science : a publication of the Protein Society. 2009 Nov ; 18 (11). 2326-35
Holinstat M , Preininger AM , Milne SB , Hudson WJ , Brown HA , Hamm HE , Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosph… Molecular pharmacology. 2009 Aug ; 76 (2). 301-13
Lin F , Chen S , Sepich DS , Panizzi JR , Clendenon SG , Marrs JA , Hamm HE , Solnica-Krezel L , Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton… The Journal of cell biology. 2009 Mar 23; 184 (6). 909-21

2008

Yoon EJ , Hamm HE , Currie KP , G protein betagamma subunits modulate the number and nature of exocytotic fusion events in adrenal c… Journal of neurophysiology. 2008 Nov ; 100 (5). 2929-39
Preininger AM , Parello J , Meier SM , Liao G , Hamm HE , Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins. Biochemistry. 2008 Sep 30; 47 (39). 10281-93
Bisegna P , Caruso G , Andreucci D , Shen L , Gurevich VV , Hamm HE , DiBenedetto E , Diffusion of the second messengers in the cytoplasm acts as a variability suppressor of the single p… Biophysical journal. 2008 May 1; 94 (9). 3363-83
Oldham WM , Hamm HE , Heterotrimeric G protein activation by G-protein-coupled receptors. Nature reviews. Molecular cell biology. 2008 Jan ; 9 (1). 60-71

2007

Oldham WM , Hamm HE , How do receptors activate G proteins? Advances in protein chemistry. 2007 ; 74 67-93
Yoon EJ , Gerachshenko T , Spiegelberg BD , Alford S , Hamm HE , Gbetagamma interferes with Ca2+-dependent binding of synaptotagmin to the soluble N-ethylmaleimide-s… Molecular pharmacology. 2007 Nov ; 72 (5). 1210-9
Bilodeau ML , Hamm HE , Regulation of protease-activated receptor (PAR) 1 and PAR4 signaling in human platelets by compartme… The Journal of pharmacology and experimental therapeutics. 2007 Aug ; 322 (2). 778-88
Voss B , McLaughlin JN , Holinstat M , Zent R , Hamm HE , PAR1, but not PAR4, activates human platelets through a Gi/o/phosphoinositide-3 kinase signaling axi… Molecular pharmacology. 2007 May ; 71 (5). 1399-406
Oldham WM , Van Eps N , Preininger AM , Hubbell WL , Hamm HE , Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric … Proceedings of the National Academy of Sciences of the United States of America. 2007 May 8; 104 (19). 7927-32
Holinstat M , Voss B , Bilodeau ML , Hamm HE , Protease-activated receptors differentially regulate human platelet activation through a phosphatidi… Molecular pharmacology. 2007 Mar ; 71 (3). 686-94
Spiegelberg BD , Hamm HE , Roles of G-protein-coupled receptor signaling in cancer biology and gene transcription. Current opinion in genetics & development. 2007 Feb ; 17 (1). 40-4

2006

Murphy SC , Harrison T , Hamm HE , Lomasney JW , Mohandas N , Haldar K , Erythrocyte G protein as a novel target for malarial chemotherapy. PLoS medicine. 2006 Dec ; 3 (12). e528
Cleator JH , Zhu WQ , Vaughan DE , Hamm HE , Differential regulation of endothelial exocytosis of P-selectin and von Willebrand factor by proteas… Blood. 2006 Apr 1; 107 (7). 2736-44
Van Eps N , Oldham WM , Hamm HE , Hubbell WL , Structural and dynamical changes in an alpha-subunit of a heterotrimeric G protein along the activat… Proceedings of the National Academy of Sciences of the United States of America. 2006 Oct 31; 103 (44). 16194-9
Holinstat M , Oldham WM , Hamm HE , G-protein-coupled receptors: evolving views on physiological signalling: symposium on G-protein-coup… EMBO reports. 2006 Sep ; 7 (9). 866-9
Caruso G , Bisegna P , Shen L , Andreucci D , Hamm HE , DiBenedetto E , Modeling the role of incisures in vertebrate phototransduction. Biophysical journal. 2006 Aug 15; 91 (4). 1192-212
Photowala H , Blackmer T , Schwartz E , Hamm HE , Alford S , G protein betagamma-subunits activated by serotonin mediate presynaptic inhibition by regulating ves… Proceedings of the National Academy of Sciences of the United States of America. 2006 Mar 14; 103 (11). 4281-6
Chen S , Hamm HE , DEP domains: More than just membrane anchors. Developmental cell. 2006 Oct ; 11 (4). 436-8
Oldham WM , Hamm HE , Structural basis of function in heterotrimeric G proteins. Quarterly reviews of biophysics. 2006 May ; 39 (2). 117-66
Oldham WM , Van Eps N , Preininger AM , Hubbell WL , Hamm HE , Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins. Nature structural & molecular biology. 2006 Sep ; 13 (9). 772-7
Holinstat M , Voss B , Bilodeau ML , McLaughlin JN , Cleator J , Hamm HE , PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 r… The Journal of biological chemistry. 2006 Sep 8; 281 (36). 26665-74
Ding J , Guzman JN , Tkatch T , Chen S , Goldberg JA , Ebert PJ , Levitt P , Wilson CJ , Hamm HE , Surmeier DJ , RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons followin… Nature neuroscience. 2006 Jun ; 9 (6). 832-42
Preininger AM , Henage LG , Oldham WM , Yoon EJ , Hamm HE , Brown HA , Direct modulation of phospholipase D activity by Gbetagamma. Molecular pharmacology. 2006 Jul ; 70 (1). 311-8
Bilodeau ML , Hamm HE , Endothelial nitric-oxide synthase reveals a new face in G protein signaling. Molecular pharmacology. 2006 Mar ; 69 (3). 677-9
Georgoussi Z , Leontiadis L , Mazarakou G , Merkouris M , Hyde K , Hamm H , Selective interactions between G protein subunits and RGS4 with the C-terminal domains of the mu- an… Cellular signalling. 2006 Jun ; 18 (6). 771-82

2005

Caruso G , Khanal H , Alexiades V , Rieke F , Hamm HE , DiBenedetto E , Mathematical and computational modelling of spatio-temporal signalling in rod phototransduction. Systems biology. 2005 Sep ; 152 (3). 119-37
Chen S , Lin F , Hamm HE , RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation… The Journal of biological chemistry. 2005 Sep 30; 280 (39). 33445-52
McLaughlin JN , Shen L , Holinstat M , Brooks JD , Dibenedetto E , Hamm HE , Functional selectivity of G protein signaling by agonist peptides and thrombin for the protease-acti… The Journal of biological chemistry. 2005 Jul 1; 280 (26). 25048-59
Gerachshenko T , Blackmer T , Yoon EJ , Bartleson C , Hamm HE , Alford S , Gbetagamma acts at the C terminus of SNAP-25 to mediate presynaptic inhibition. Nature neuroscience. 2005 May ; 8 (5). 597-605
McLaughlin JN , Mazzoni MR , Cleator JH , Earls L , Perdigoto AL , Brooks JD , Muldowney JA , Vaughan DE , Hamm HE , Thrombin modulates the expression of a set of genes including thrombospondin-1 in human microvascula… The Journal of biological chemistry. 2005 Jun 10; 280 (23). 22172-80
Blackmer T , Larsen EC , Bartleson C , Kowalchyk JA , Yoon EJ , Preininger AM , Alford S , Hamm HE , Martin TF , G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytos… Nature neuroscience. 2005 Apr ; 8 (4). 421-5
Lin F , Sepich DS , Chen S , Topczewski J , Yin C , Solnica-Krezel L , Hamm H , Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence … The Journal of cell biology. 2005 Jun 6; 169 (5). 777-87
Lukov GL , Hu T , McLaughlin JN , Hamm HE , Willardson BM , Phosducin-like protein acts as a molecular chaperone for G protein betagamma dimer assembly. The EMBO journal. 2005 Jun 1; 24 (11). 1965-75

2004

Chen S , Spiegelberg BD , Lin F , Dell EJ , Hamm HE , Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins. Journal of molecular and cellular cardiology. 2004 Aug ; 37 (2). 399-406
Srinivasan C , Toon J , Amari L , Abukhdeir AM , Hamm H , Geraldes CF , Ho YK , Mota de Freitas D , Competition between lithium and magnesium ions for the G-protein transducin in the guanosine 5′-diph… Journal of inorganic biochemistry. 2004 May ; 98 (5). 691-701
Chen S , Dell EJ , Lin F , Sai J , Hamm HE , RACK1 regulates specific functions of Gbetagamma. The Journal of biological chemistry. 2004 Apr 23; 279 (17). 17861-8
Preininger AM , Hamm HE , G protein signaling: insights from new structures. Science's STKE : signal transduction knowledge environment. 2004 Feb 3; 2004 (218). re3
Cabrera-Vera TM , Hernandez S , Earls LR , Medkova M , Sundgren-Andersson AK , Surmeier DJ , Hamm HE , RGS9-2 modulates D2 dopamine receptor-mediated Ca2+ channel inhibition in rat striatal cholinergic i… Proceedings of the National Academy of Sciences of the United States of America. 2004 Nov 16; 101 (46). 16339-44

2003

Harrison U. , Samuel , Akompong , Hamm , Mohandas W. , Lomasney Jon , Haldar Kasturi , Erythrocyte G Protein–Coupled Receptor Signaling in Malarial Infection 2003 Sep 19; 301
Preininger M. , Eps Van , Yu , Medkova , Hubbell L. , Hamm Heidi , The Myristoylated Amino Terminus of GRi1 Plays a Critical Role in the Structure and Function of GRi… 2003 May 11; 42 7931-7941
Chen NF , Yu JZ , Skiba NP , Hamm HE , Rasenick MM , A specific domain of Gialpha required for the transactivation of Gialpha by tubulin is implicated in… The Journal of biological chemistry. 2003 Apr 25; 278 (17). 15285-90
Andreucci D , Bisegna P , Caruso G , Hamm HE , DiBenedetto E , Mathematical model of the spatio-temporal dynamics of second messengers in visual transduction. Biophysical journal. 2003 Sep ; 85 (3). 1358-76
Cabrera-Vera TM , Vanhauwe J , Thomas TO , Medkova M , Preininger A , Mazzoni MR , Hamm HE , Insights into G protein structure, function, and regulation. Endocrine reviews. 2003 Dec ; 24 (6). 765-81

2002

Dell J. , Connor , Chen , Stebbins G. , Skiba P. , Mochly-Rosen , Hamm E. , The BetaGamma Subunit of Heterotrimeric G Proteins Interacts with RACK1 and Two Other WD Repeat Prot… 2002 Dec 20; 51 (277). 49888–49895
Gilchrist E. , Li Anli , Hamm Heidi , Gα COOH-Terminal Minigene Vectors Dissect Heterotrimeric G Protein Signaling 2002 Feb 5;

1994

Arshavsky Y. , Dumke L. , Zhu , Artemyev O. , Skiba P. , Regulation of Transducin GTPase Activity in Bovine Rod Outer Segments* Regulation of Transducin GTPase Activity in Bovine Rod Outer Segments*. 1994 Aug 5; 269 (31). 19882-19887
Rasenick M. , Watanabe , Lazarevic B. , Hatta , Hamm E. , Synthetic Peptides as Probes for G Protein Function 1994 Aug 26; 269 (34). 21519-21525
Artemyev NO , Hamm HE , Probing G-protein function. Nature structural biology. 1994 Nov ; 1 (11). 752-4
Krupnick G. , Gurevich V. , Schepers , Hamm E. , Benovic L. , Arrestin-Rhodopsin Interaction Arrestin-Rhodopsin Interaction. 1994 Feb 4; 269 (5). 3226-3232

1993

Noel JP , Hamm HE , Sigler PB , The 2.2 A crystal structure of transducin-alpha complexed with GTP gamma S. Nature. 1993 Dec 16; 366 (6456). 654-63
Hargrave PA , Hamm HE , Hofmann KP , Interaction of rhodopsin with the G-protein, transducin. BioEssays : news and reviews in molecular, cellular and developmental biology. 1993 Jan ; 15 (1). 43-50

1992

Rarick HM , Artemyev NO , Hamm HE , A site on rod G protein alpha subunit that mediates effector activation. Science (New York, N.Y.). 1992 May 15; 256 (5059). 1031-3

1991

Mazzoni A. , Malinski E. , Hamm Heidi , Structural Analysis of Rod GTP-binding Protein, Gt Structural Analysis of Rod GTP-binding Protein, Gt. 1991 Jul 25; 266 (21). 14072-14081
Warpeha M.F. , Hamm E. , Rasenick M. , A blue-light-activated GTP-binding protein in the plasma membranes of etiolated peas A blue-light-activated GTP-binding protein in the plasma membranes of etiolated peas. 1991 Oct ; 88 8925-8929

1990

Hamm HE , Surfaces of interaction between Gt and rhodopsin in the GDP-bound and empty-pocket configurations. Advances in second messenger and phosphoprotein research. 1990 ; 24 76-82

1989

Pepe IM , Panfoli I , Hamm HE , Visual transduction in vertebrate photoreceptors. Light activation of guanylate cyclase. Cell biophysics. 1989 Apr ; 14 (2). 129-37
Mazzoni MR , Hamm HE , Effect of monoclonal antibody binding on alpha-beta gamma subunit interactions in the rod outer segm… Biochemistry. 1989 Dec 12; 28 (25). 9873-80
Hamm E. , Deretic , Mazzoni R. , Moore Ann , Takahashi S. , Rasenick M. , A Monoclonal Antibody against the Rod Outer Segment Guanyl Nucleotide-binding Protein, Transducin, B… A Monoclonal Antibody against the Rod Outer Segment Guanyl Nucleotide-binding Protein, Transducin, Blocks the Stimulatory and Inhibitory G Proteins of Adenylate Cyclase*. 1989 Jul 5; 264 (19). 11475-11482
Wood CJ , Aggleton JP , Handedness in ‘fast ball’ sports: do left-handers have an innate advantage? British journal of psychology (London, England : 1953). 1989 May ; 80 ( Pt 2) 227-40

1988

Yatani A , Hamm H , Codina J , Mazzoni MR , Birnbaumer L , Brown AM , A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels. Science (New York, N.Y.). 1988 Aug 12; 241 (4867). 828-31
Hamm HE , Deretic D , Arendt A , Hargrave PA , Koenig B , Hofmann KP , Site of G protein binding to rhodopsin mapped with synthetic peptides from the alpha subunit. Science (New York, N.Y.). 1988 Aug 12; 241 (4867). 832-5

1987

Hamm HE , Deretic D , Hofmann KP , Schleicher A , Kohl B , Mechanism of action of monoclonal antibodies that block the light activation of the guanyl nucleotid… The Journal of biological chemistry. 1987 Aug 5; 262 (22). 10831-8
Deretic D , Hamm HE , Topographic analysis of antigenic determinants recognized by monoclonal antibodies to the photorecep… The Journal of biological chemistry. 1987 Aug 5; 262 (22). 10839-47

1986

Hamm HE , Bownds MD , Protein complement of rod outer segments of frog retina. Biochemistry. 1986 Aug 12; 25 (16). 4512-23

1984

Hamm HE , Bownds MD , A monoclonal antibody to guanine nucleotide binding protein inhibits the light-activated cyclic GMP … The Journal of general physiology. 1984 Aug ; 84 (2). 265-80
Witt PL , Hamm HE , Bownds MD , Preparation and characterization of monoclonal antibodies to several frog rod outer segment proteins… The Journal of general physiology. 1984 Aug ; 84 (2). 251-63

1983

Hamm HE , Takahashi JS , Menaker M , Light-induced decrease of serotonin N-acetyltransferase activity and melatonin in the chicken pineal… Brain research. 1983 May 5; 266 (2). 287-93

1982

Hermolin J , Karell MA , Hamm HE , Bownds MD , Calcium and cyclic GMP regulation of light-sensitive protein phosphorylation in frog photoreceptor m… The Journal of general physiology. 1982 Apr ; 79 (4). 633-55

1981

Hamm HE , Menaker M , Pineal and retinal serotonin N-acetyltransferase activity: modulation by phosphate. Journal of neurochemistry. 1981 Dec ; 37 (6). 1567-72

1980

Hamm HE , Menaker M , Retinal rhythms in chicks: circadian variation in melantonin and serotonin N-acetyltransferase activ… Proceedings of the National Academy of Sciences of the United States of America. 1980 Aug ; 77 (8). 4998-5002

Bertron JL , Durvernay MT , Mitchell SG , Smith ST , Maeng JG , Blodaum AL , Davis DC , Meiler J , Hamm HE , Lindsley CW , Discovery and Optimization of a Novel Series of Competitive and Central Nervous System-Penetrant Protease-Activated Receptor 4 (PAR4) Inhibitors. ACS Chemical Neuroscience. ; 12 (24). 4524-4534
Klaus C , Caruso G , Gurevich VV , Hamm HE , Makino CL , DiBenedetto E , Phototransduction in retinal cones: Analysis of parameter importance. PLoS One. ; 10 (16). 0258721
Slessareva E. , Ma , Depree M. , Flood A. , Bae , Cabrere-Vera M. , Hamm E. , Graber G. , Closely related G protein coupled receptors use multiple and distinct domains on G protein α subun… ;
Thaker TM , Kaya AI , Preininger AM , Hamm HE , Iverson TM , Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective. ;
Huang K , Voss B , Kumar D , Hamm HE , Harth E , Dendritic molecular transporters provide control of delivery to intracellular compartments. Bioconjugate chemistry. ; 18 (2). 403-9