Skip to main content

DEP domains: More than just membrane anchors.


Chen SSonghai , Hamm HE Heidi E . Developmental cell. 2006 10 ; 11(4). 436-8


The DEP domain is present in a number of signaling molecules, including Regulator of G protein Signaling (RGS) proteins, and has been implicated in membrane targeting. New findings in yeast, however, demonstrate a major role for a DEP domain in mediating the interaction of an RGS protein to the C-terminal tail of a GPCR, thus placing RGS in close proximity with its substrate G protein alpha subunit.