The hyperglycemic byproduct methylglyoxal impairs anticoagulant activity through covalent adduction of antithrombin III.
AUTHORS
Jacobson
R ,
Mignemi
N ,
Rose
K ,
O'Rear
L ,
Sarilla
S ,
Hamm
HE ,
Barnett
JV ,
Verhamme
IM ,
Schoenecker
J .
Thrombosis Research. 2014 12 ; 134(6).
1350-7
- PMID: 25307422[PubMed].