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Erythrocyte G protein as a novel target for malarial chemotherapy.


Murphy SCSean C , Harrison T Travis , Hamm HE Heidi E , Lomasney JW Jon W , Mohandas N Narla , Haldar K Kasturi . PLoS medicine. 2006 12 ; 3(12). e528


Malaria remains a serious health problem because resistance develops to all currently used drugs when their parasite targets mutate. Novel antimalarial drug targets are urgently needed to reduce global morbidity and mortality. Our prior results suggested that inhibiting erythrocyte Gs signaling blocked invasion by the human malaria parasite Plasmodium falciparum.