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Broadie Laboratory

Broadie Laboratory Publications

2024

Nelson N , Vita D , Broadie K , Experience-dependent glial pruning of synaptic glomeruli during the critical period Sci Rep. 2024 ;
Leahy S , Vita D , Broadie K , PTPN11/Corkscrew activates local presynaptic MAPK signaling to regulate Synapsin, synaptic vesicle pools, and neurotransmission strength, with a dual requirement in neurons and glia J Neurosci. 2024 ;
Nelson N , Miller V , Baumann N , Broadie K , Experience-Dependent Remodeling of Juvenile Brain Olfactory Sensory Neuron Synaptic Connectivity in an Early-Life Critical Period JoVE. 2024 ;
Sears J , Broadie K , Use-dependent, untapped dual kinase signaling localized in brain learning circuitry J Neurosci. 2024 ;

2023

Eberwein A , Kulkarni S , Rushton E , Broadie K , Glycosphingolipids are linked to elevated neurotransmission and neurodegeneration in a Drosophila model of Niemann Pick type C DMM. 2023 ;
Song C , Broadie K , Fragile X mental retardation protein coordinates neuron-to-glia communication for clearance of developmentally transient brain neurons Proc Natl Acad Sci. 2023 ;
Leahy SN , Song C , Vita DJ , Broadie K , FMRP activity and control of Csw/SHP2 translation regulate MAPK-dependent synaptic transmission PLoS Biol. 2023 ;

2022

Song C , Broadie K , Dysregulation of BMP, Wnt, and Insulin Signaling in Fragile X Syndrome Front Cell Dev Biol. 2022 ;
Song C , Leahy SN , Rushton EM , Broadie K , RNA-binding FMRP and Staufen sequentially regulate the Coracle scaffold to control synaptic glutamate receptor and bouton development Development. 2022 ;
Sears J , Broadie K , Temporally and Spatially Localized PKA Activity within Learning and Memory Circuitry Regulated by Network Feedback eNeuro. 2022 ;

2021

Bhimreddy M , Rushton E , Kopke DL , Broadie K , Secreted C-type lectin regulation of neuromuscular junction synaptic vesicle dynamics modulates coordinated movement J Cell Sci.. 2021 ;
Vita DJ , Meier CJ , Broadie K , Neuronal fragile X mental retardation protein activates glial insulin receptor mediated PDF-Tri neuron developmental clearance Nature Communications. 2021 Feb 19;
Golovin RM , Vest J , Broadie K , Neuron-Specific FMRP Roles in Experience-Dependent Remodeling of Olfactory Brain Innervation During an Early-life Critical Period J Neurosci. 2021 Jan 4;

2020

Sivadas A , Broadie K , HOW DOES MY BRAIN COMMUNICATE WITH MY BODY? Front Young Minds. 2020 Oct 8;
Tackenberg MC , Giannoni-Guzman MA , Sanchez-Perez E , Doll CA , Agosto-Rivera JL , Broadie K , Moore D , McMahon DG , Neonicotinoids disrupt circadian rhythms and sleep in honey bees Sci Rep. 2020 Oct 21;
Sears JC , Broadie K , FMRP-PKA Activity Negative Feedback Regulates RNA Binding-Dependent Fibrillation in Brain Learning and Memory Circuitry Cell Rep. 2020 Oct 13;
Rushton E , Kopke DL , Broadie K , Extracellular heparan sulfate proteoglycans and glycan-binding lectins orchestrate trans-synaptic signaling J Cell Sci. 2020 Aug 11;
Kennedy T , Rinker D , Broadie K , Genetic background mutations drive neural circuit hyperconnectivity in a fragile X syndrome model BMC Biol. 2020 Jul 30;
Kopke DL , Leahy SN , Vita DJ , Lima SC , Newman ZL , Broadie K , Carrier of Wingless (Cow) Regulation of Drosophila Neuromuscular Junction Development eNeuro. 2020 Mar 10;

2019

Sears JC , Choi WJ , Broadie K , Fragile X Mental Retardation Protein positively regulates PKA anchor Rugose and PKA activity to control actin assembly in learning/memory circuitry Neurobiology of Disease. 2019 Feb 13;
Golovin RM , Vest J , Vita DJ , Broadie K , Activity-Dependent Remodeling of Drosophila Olfactory Sensory Neuron Brain Innervation During an Early-Life Critical Period Journal of Neuroscience. 2019 Feb 12;
Kim N , Kim S , Nahm M , Kopke D , Kim J , Cho E , Lee MJ , Kim SH , Broadie K , Lee S , BMP-dependent synaptic development requires Abi-Abl-Rac signaling of BMP receptor macropinocytosis Nature Communications. 2019 Feb 8;

2018

Kennedy T , Broadie K , Newly Identified Electrically Coupled Neurons Support Development of the Drosophila Giant Fiber Model Circuit eNeuro. 2018 Dec 14;
Kopke DL , Broadie K , FM Dye Cycling at the Synapse: Comparing High Potassium Depolarization, Electrical and Channelrhodopsin Stimulation Journal of Visualized Experiments. 2018 May 24;
Sears JC , Broadie K , Fragile X Mental Retardation Protein Regulates Activity-Dependent Membrane Trafficking and Trans-Synaptic Signaling Mediating Synaptic Remodeling. 2018 Jan 12;

2017

Kennedy T , Broadie K , Fragile X Mental Retardation Protein Restricts Small Dye Iontophoresis Entry into Central Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2017 Sep 7;
Kopke DL , Lima SC , Alexandre C , Broadie K , Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling. Development (Cambridge, England). 2017 Oct 1; 144 (19). 3499-3510
Davis JK , Broadie K , Multifarious Functions of the Fragile X Mental Retardation Protein. Trends in genetics : TIG. 2017 Oct ; 33 (10). 703-714
Vita DJ , Broadie K , ESCRT-III Membrane Trafficking Misregulation Contributes To Fragile X Syndrome Synaptic Defects. Scientific reports. 2017 Aug 17; 7 (1). 8683
Doll CA , Vita DJ , Broadie K , Fragile X Mental Retardation Protein Requirements in Activity-Dependent Critical Period Neural Circuit Refinement. Current biology : CB. 2017 Aug 7; 27 (15). 2318-2330.e3
Dear ML , Shilts J , Broadie K , Neuronal activity drives FMRP- and HSPG-dependent matrix metalloproteinase function required for rapid synaptogenesis. Science signaling. 2017 Nov 7; 10 (504).

2013

Wei C , Thatcher EJ , Olena AF , Cha DJ , Perdigoto AL , Marshall AF , Carter BD , Broadie K , Patton JG , miR-153 regulates SNAP-25, synaptic transmission, and neuronal development. PloS one. 2013 ; 8 (2). e57080
Nahm M , Lee MJ , Parkinson W , Lee M , Kim H , Kim YJ , Kim S , Cho YS , Min BM , Bae YC , Broadie K , Lee S , Spartin regulates synaptic growth and neuronal survival by inhibiting BMP-mediated microtubule stabilization. Neuron. 2013 Feb 20; 77 (4). 680-95
Staples J , Broadie K , The cell polarity scaffold Lethal Giant Larvae regulates synapse morphology and function. Journal of cell science. 2013 May 1; 126 (Pt 9). 1992-2003
Guss KA , Benson M , Gubitosi N , Brondell K , Broadie K , Skeath JB , Expression and function of scalloped during Drosophila development. Developmental dynamics : an official publication of the American Association of Anatomists. 2013 Jul ; 242 (7). 874-85
Friedman SH , Dani N , Rushton E , Broadie K , Fragile X mental retardation protein regulates trans-synaptic signaling in Drosophila. Disease models & mechanisms. 2013 Nov ; 6 (6). 1400-13
Parkinson W , Dear ML , Rushton E , Broadie K , N-glycosylation requirements in neuromuscular synaptogenesis. Development (Cambridge, England). 2013 Dec ; 140 (24). 4970-81

2014

Gatto CL , Pereira D , Broadie K , GABAergic circuit dysfunction in the Drosophila Fragile X syndrome model. Neurobiology of disease. 2014 May ; 65 142-59
Doll CA , Broadie K , Impaired activity-dependent neural circuit assembly and refinement in autism spectrum disorder genetic models. Frontiers in cellular neuroscience. 2014 ; 8 30
Dani N , Zhu H , Broadie K , Two protein N-acetylgalactosaminyl transferases regulate synaptic plasticity by activity-dependent regulation of integrin signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2014 Sep 24; 34 (39). 13047-65
Jumbo-Lucioni P , Parkinson W , Broadie K , Overelaborated synaptic architecture and reduced synaptomatrix glycosylation in a Drosophila classic galactosemia disease model. Disease models & mechanisms. 2014 Dec ; 7 (12). 1365-78

2015

Doll CA , Broadie K , Activity-dependent FMRP requirements in development of the neural circuitry of learning and memory. Development (Cambridge, England). 2015 Apr 1; 142 (7). 1346-56

2011

Broadie K , Baumgartner S , Prokop A , Extracellular matrix and its receptors in Drosophila neural development. Developmental neurobiology. 2011 Nov ; 71 (11). 1102-30

2017

Shilts J , Broadie K , Secreted tissue inhibitor of matrix metalloproteinase restricts trans-synaptic signaling to coordinate synaptogenesis. Journal of cell science. 2017 Jun 2;
Golovin RM , Broadie K , Neural Circuits: Reduced Inhibition in Fragile X Syndrome. Current biology : CB. 2017 Apr 24; 27 (8). R298-R300

2016

Golovin RM , Broadie K , Developmental experience-dependent plasticity in the first synapse of the Drosophila olfactory circuit. Journal of neurophysiology. 2016 Dec 1; 116 (6). 2730-2738
Jumbo-Lucioni PP , Parkinson WM , Kopke DL , Broadie K , Coordinated movement, neuromuscular synaptogenesis and trans-synaptic signaling defects in Drosophila galactosemia models. Human molecular genetics. 2016 Sep 1; 25 (17). 3699-3714
Parkinson WM , Dookwah M , Dear ML , Gatto CL , Aoki K , Tiemeyer M , Broadie K , Synaptic roles for phosphomannomutase type 2 in a new Drosophila congenital disorder of glycosylation disease model. Disease models & mechanisms. 2016 May 1; 9 (5). 513-27
Doll CA , Broadie K , Neuron class-specific requirements for Fragile X Mental Retardation Protein in critical period development of calcium signaling in learning and memory circuitry. Neurobiology of disease. 2016 May ; 89 76-87
Jiang H , Hanna E , Gatto CL , Page TL , Bhuva B , Broadie K , A fully automated Drosophila olfactory classical conditioning and testing system for behavioral learning and memory assessment. Journal of neuroscience methods. 2016 Mar 1; 261 62-74
Dear ML , Dani N , Parkinson W , Zhou S , Broadie K , Two classes of matrix metalloproteinases reciprocally regulate synaptogenesis. Development (Cambridge, England). 2016 Jan 1; 143 (1). 75-87

2009

Gatto CL , Broadie K , The fragile X mental retardation protein in circadian rhythmicity and memory consolidation. Molecular neurobiology. 2009 Apr ; 39 (2). 107-29
Rushton E , Rohrbough J , Broadie K , Presynaptic secretion of mind-the-gap organizes the synaptic extracellular matrix-integrin interface and postsynaptic environments. Developmental dynamics : an official publication of the American Association of Anatomists. 2009 Mar ; 238 (3). 554-71
Tessier CR , Broadie K , Activity-dependent modulation of neural circuit synaptic connectivity. Frontiers in molecular neuroscience. 2009 ; 2 8
Gatto CL , Broadie K , Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture. Frontiers in neural circuits. 2009 ; 3 8

2010

Gatto CL , Broadie K , Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models. Frontiers in synaptic neuroscience. 2010 ; 2 4
Kliman M , Vijayakrishnan N , Wang L , Tapp JT , Broadie K , McLean JA , Structural mass spectrometry analysis of lipid changes in a Drosophila epilepsy model brain. Molecular bioSystems. 2010 Jun ; 6 (6). 958-66
Coffee RL , Tessier CR , Woodruff EA , Broadie K , Fragile X mental retardation protein has a unique, evolutionarily conserved neuronal function not shared with FXR1P or FXR2P. Disease models & mechanisms. 2010 ; 3 (7-8). 471-85
Long AA , Mahapatra CT , Woodruff EA , Rohrbough J , Leung HT , Shino S , An L , Doerge RW , Metzstein MM , Pak WL , Broadie K , The nonsense-mediated decay pathway maintains synapse architecture and synaptic vesicle cycle efficacy. Journal of cell science. 2010 Oct 1; 123 (Pt 19). 3303-15

2011

Tessier CR , Broadie K , The fragile X mental retardation protein developmentally regulates the strength and fidelity of calcium signaling in Drosophila mushroom body neurons. Neurobiology of disease. 2011 Jan ; 41 (1). 147-59

2010

Rohrbough J , Broadie K , Anterograde Jelly belly ligand to Alk receptor signaling at developing synapses is regulated by Mind the gap. Development (Cambridge, England). 2010 Oct ; 137 (20). 3523-33
Vijayakrishnan N , Phillips SE , Broadie K , Drosophila rolling blackout displays lipase domain-dependent and -independent endocytic functions downstream of dynamin. Traffic (Copenhagen, Denmark). 2010 Dec ; 11 (12). 1567-78

2012

Dani N , Broadie K , Glycosylated synaptomatrix regulation of trans-synaptic signaling. Developmental neurobiology. 2012 Jan ; 72 (1). 2-21

2011

Gatto CL , Broadie K , Drosophila modeling of heritable neurodevelopmental disorders. Current opinion in neurobiology. 2011 Dec ; 21 (6). 834-41
Gatto CL , Broadie K , Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons. Developmental biology. 2011 Aug 15; 356 (2). 291-307
Siller SS , Broadie K , Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. Disease models & mechanisms. 2011 Sep ; 4 (5). 673-85

2012

Coffee RL , Williamson AJ , Adkins CM , Gray MC , Page TL , Broadie K , In vivo neuronal function of the fragile X mental retardation protein is regulated by phosphorylation. Human molecular genetics. 2012 Feb 15; 21 (4). 900-15
Rushton E , Rohrbough J , Deutsch K , Broadie K , Structure-function analysis of endogenous lectin mind-the-gap in synaptogenesis. Developmental neurobiology. 2012 Aug ; 72 (8). 1161-79
Siller SS , Broadie K , Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome. Neural plasticity. 2012 ; 2012 124548
Dani N , Nahm M , Lee S , Broadie K , A targeted glycan-related gene screen reveals heparan sulfate proteoglycan sulfation regulates WNT and BMP trans-synaptic signaling. PLoS genetics. 2012 ; 8 (11). e1003031

2013

Rohrbough J , Kent KS , Broadie K , Weiss JB , Jelly Belly trans-synaptic signaling to anaplastic lymphoma kinase regulates neurotransmission strength and synapse architecture. Developmental neurobiology. 2013 Mar ; 73 (3). 189-208

2005

Featherstone DE , Rushton E , Rohrbough J , Liebl F , Karr J , Sheng Q , Rodesch CK , Broadie K , An essential Drosophila glutamate receptor subunit that functions in both central neuropil and neuromuscular junction. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005 Mar 23; 25 (12). 3199-208

2006

Huang FD , Woodruff E , Mohrmann R , Broadie K , Rolling blackout is required for synaptic vesicle exocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006 Mar 1; 26 (9). 2369-79
Vijayakrishnan N , Broadie K , Temperature-sensitive paralytic mutants: insights into the synaptic vesicle cycle. Biochemical Society transactions. 2006 Feb ; 34 (Pt 1). 81-7

2007

Yan Y , Broadie K , In vivo assay of presynaptic microtubule cytoskeleton dynamics in Drosophila. Journal of neuroscience methods. 2007 May 15; 162 (1-2). 198-205
Pan L , Broadie KS , Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A convergently regulate the synaptic ratio of ionotropic glutamate receptor subclasses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007 Nov 7; 27 (45). 12378-89
Haas KF , Miller SL , Friedman DB , Broadie K , The ubiquitin-proteasome system postsynaptically regulates glutamatergic synaptic function. Molecular and cellular neurosciences. 2007 May ; 35 (1). 64-75
Haas KF , Woodruff E , Broadie K , Proteasome function is required to maintain muscle cellular architecture. Biology of the cell / under the auspices of the European Cell Biology Organization. 2007 Nov ; 99 (11). 615-26
Rohrbough J , Rushton E , Woodruff E , Fergestad T , Vigneswaran K , Broadie K , Presynaptic establishment of the synaptic cleft extracellular matrix is required for post-synaptic differentiation. Genes & development. 2007 Oct 15; 21 (20). 2607-28

2008

Kucenas S , Takada N , Park HC , Woodruff E , Broadie K , Appel B , CNS-derived glia ensheath peripheral nerves and mediate motor root development. Nature neuroscience. 2008 Feb ; 11 (2). 143-51
Haas KF , Broadie K , Roles of ubiquitination at the synapse. Biochimica et biophysica acta. 2008 Aug ; 1779 (8). 495-506
Pan L , Woodruff E , Liang P , Broadie K , Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling. Molecular and cellular neurosciences. 2008 Apr ; 37 (4). 747-60
Tessier CR , Broadie K , Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning. Development (Cambridge, England). 2008 Apr ; 135 (8). 1547-57
Reeve SP , Lin X , Sahin BH , Jiang F , Yao A , Liu Z , Zhi H , Broadie K , Li W , Giangrande A , Hassan BA , Zhang YQ , Mutational analysis establishes a critical role for the N terminus of fragile X mental retardation protein FMRP. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Mar 19; 28 (12). 3221-6
Long AA , Kim E , Leung HT , Woodruff E , An L , Doerge RW , Pak WL , Broadie K , Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Apr 2; 28 (14). 3668-82
Gatto CL , Broadie K , Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure. Development (Cambridge, England). 2008 Aug ; 135 (15). 2637-48
Phillips SE , Woodruff EA , Liang P , Patten M , Broadie K , Neuronal loss of Drosophila NPC1a causes cholesterol aggregation and age-progressive neurodegeneration. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Jun 25; 28 (26). 6569-82
Bolduc FV , Bell K , Cox H , Broadie KS , Tully T , Excess protein synthesis in Drosophila fragile X mutants impairs long-term memory. Nature neuroscience. 2008 Oct ; 11 (10). 1143-5
Woodruff EA , Broadie K , Honegger HW , Two peptide transmitters co-packaged in a single neurosecretory vesicle. Peptides. 2008 Dec ; 29 (12). 2276-80

2009

Repicky S , Broadie K , Metabotropic glutamate receptor-mediated use-dependent down-regulation of synaptic excitability involves the fragile X mental retardation protein. Journal of neurophysiology. 2009 Feb ; 101 (2). 672-87
Vijayakrishnan N , Woodruff EA , Broadie K , Rolling blackout is required for bulk endocytosis in non-neuronal cells and neuronal synapses. Journal of cell science. 2009 Jan 1; 122 (Pt 1). 114-25

2004

Pan L , Zhang YQ , Woodruff E , Broadie K , The Drosophila fragile X gene negatively regulates neuronal elaboration and synaptic differentiation. Current biology : CB. 2004 Oct 26; 14 (20). 1863-70

2005

Zhang YQ , Friedman DB , Wang Z , Woodruff E , Pan L , O'donnell J , Broadie K , Protein expression profiling of the drosophila fragile X mutant brain reveals up-regulation of monoamine synthesis. Molecular & cellular proteomics : MCP. 2005 Mar ; 4 (3). 278-90
Zhang YQ , Broadie K , Fathoming fragile X in fruit flies. Trends in genetics : TIG. 2005 Jan ; 21 (1). 37-45
Rohrbough J , Broadie K , Lipid regulation of the synaptic vesicle cycle. Nature reviews. Neuroscience. 2005 Feb ; 6 (2). 139-50
Broadie K , Pan L , Translational complexity of the fragile x mental retardation protein: insights from the fly. Molecular cell. 2005 Mar 18; 17 (6). 757-9

2002

Broadie KS , Richmond JE , Establishing and sculpting the synapse in Drosophila and C. elegans. Current opinion in neurobiology. 2002 Oct ; 12 (5). 491-8
Richmond JE , Broadie KS , The synaptic vesicle cycle: exocytosis and endocytosis in Drosophila and C. elegans. Current opinion in neurobiology. 2002 Oct ; 12 (5). 499-507

2003

Rohrbough J , O'Dowd DK , Baines RA , Broadie K , Cellular bases of behavioral plasticity: establishing and modifying synaptic circuits in the Drosophila genetic system. Journal of neurobiology. 2003 Jan ; 54 (1). 254-71
Aravamudan B , Broadie K , Synaptic Drosophila UNC-13 is regulated by antagonistic G-protein pathways via a proteasome-dependent degradation mechanism. Journal of neurobiology. 2003 Feb 15; 54 (3). 417-38
Matthies HJ , Broadie K , Techniques to dissect cellular and subcellular function in the Drosophila nervous system. Methods in cell biology. 2003 ; 71 195-265
Renden RB , Broadie K , Mutation and activation of Galpha s similarly alters pre- and postsynaptic mechanisms modulating neurotransmission. Journal of neurophysiology. 2003 May ; 89 (5). 2620-38
Speese SD , Trotta N , Rodesch CK , Aravamudan B , Broadie K , The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Current biology : CB. 2003 May 27; 13 (11). 899-910

2004

Featherstone David , Broadie Kendal , Functional Development of the Neuromusculature 2004 ;
Trotta N , Rodesch CK , Fergestad T , Broadie K , Cellular bases of activity-dependent paralysis in Drosophila stress-sensitive mutants. Journal of neurobiology. 2004 Sep 5; 60 (3). 328-47
Zhang YQ , Matthies HJ , Mancuso J , Andrews HK , Woodruff E , Friedman D , Broadie K , The Drosophila fragile X-related gene regulates axoneme differentiation during spermatogenesis. Developmental biology. 2004 Jun 15; 270 (2). 290-307
Broadie K , Axon pruning: an active role for glial cells. Current biology : CB. 2004 Apr 20; 14 (8). R302-4
Huang FD , Matthies HJ , Speese SD , Smith MA , Broadie K , Rolling blackout, a newly identified PIP2-DAG pathway lipase required for Drosophila phototransduction. Nature neuroscience. 2004 Oct ; 7 (10). 1070-8
Bogdanik L , Mohrmann R , Ramaekers A , Bockaert J , Grau Y , Broadie K , Parmentier ML , The Drosophila metabotropic glutamate receptor DmGluRA regulates activity-dependent synaptic facilitation and fine synaptic morphology. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Oct 13; 24 (41). 9105-16
Rohrbough J , Rushton E , Palanker L , Woodruff E , Matthies HJ , Acharya U , Acharya JK , Broadie K , Ceramidase regulates synaptic vesicle exocytosis and trafficking. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2004 Sep 8; 24 (36). 7789-803
Trotta N , Orso G , Rossetto MG , Daga A , Broadie K , The hereditary spastic paraplegia gene, spastin, regulates microtubule stability to modulate synaptic structure and function. Current biology : CB. 2004 Jul 13; 14 (13). 1135-47

1999

Aravamudan B , Fergestad T , Davis WS , Rodesch CK , Broadie K , Drosophila UNC-13 is essential for synaptic transmission. Nature neuroscience. 1999 Nov ; 2 (11). 965-71
Beumer KJ , Rohrbough J , Prokop A , Broadie K , A role for PS integrins in morphological growth and synaptic function at the postembryonic neuromuscular junction of Drosophila. Development (Cambridge, England). 1999 Dec ; 126 (24). 5833-46

2000

Zhang Y , Featherstone D , Davis W , Rushton E , Broadie K , Drosophila D-titin is required for myoblast fusion and skeletal muscle striation. Journal of cell science. 2000 Sep ; 113 ( Pt 17) 3103-15
Broadie Kendal , Electrophysiological approaches to the neuromusculature 2000 ; 273-296
Broadie Kendal , Functional assays of the peripheral and central nervous systems. Drosophila Protocols 2000 ; 297-312
Featherstone DE , Rushton EM , Hilderbrand-Chae M , Phillips AM , Jackson FR , Broadie K , Presynaptic glutamic acid decarboxylase is required for induction of the postsynaptic receptor field at a glutamatergic synapse. Neuron. 2000 Jul ; 27 (1). 71-84
Featherstone DE , Broadie K , Surprises from Drosophila: genetic mechanisms of synaptic development and plasticity. Brain research bulletin. 2000 Nov 15; 53 (5). 501-11
Rohrbough J , Grotewiel MS , Davis RL , Broadie K , Integrin-mediated regulation of synaptic morphology, transmission, and plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2000 Sep 15; 20 (18). 6868-78
Rodesch CK , Broadie K , Genetic studies in Drosophila: vesicle pools and cytoskeleton-based regulation of synaptic transmission. Neuroreport. 2000 Dec 18; 11 (18). R45-53

2001

Fergestad T , Broadie K , Interaction of stoned and synaptotagmin in synaptic vesicle endocytosis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Feb 15; 21 (4). 1218-27
Bodily KD , Morrison CM , Renden RB , Broadie K , A novel member of the Ig superfamily, turtle, is a CNS-specific protein required for coordinated motor control. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 May 1; 21 (9). 3113-25
Renden R , Berwin B , Davis W , Ann K , Chin CT , Kreber R , Ganetzky B , Martin TF , Broadie K , Drosophila CAPS is an essential gene that regulates dense-core vesicle release and synaptic vesicle fusion. Neuron. 2001 Aug 16; 31 (3). 421-37
Featherstone DE , Davis WS , Dubreuil RR , Broadie K , Drosophila alpha- and beta-spectrin mutations disrupt presynaptic neurotransmitter release. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Jun 15; 21 (12). 4215-24
Fergestad T , Wu MN , Schulze KL , Lloyd TE , Bellen HJ , Broadie K , Targeted mutations in the syntaxin H3 domain specifically disrupt SNARE complex function in synaptic transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2001 Dec 1; 21 (23). 9142-50
Zhang YQ , Bailey AM , Matthies HJ , Renden RB , Smith MA , Speese SD , Rubin GM , Broadie K , Drosophila fragile X-related gene regulates the MAP1B homolog Futsch to control synaptic structure and function. Cell. 2001 Nov 30; 107 (5). 591-603

2002

Beumer K , Matthies HJ , Bradshaw A , Broadie K , Integrins regulate DLG/FAS2 via a CaM kinase II-dependent pathway to mediate synapse elaboration and stabilization during postembryonic development. Development (Cambridge, England). 2002 Jul ; 129 (14). 3381-91
Featherstone DE , Rushton E , Broadie K , Developmental regulation of glutamate receptor field size by nonvesicular glutamate release. Nature neuroscience. 2002 Feb ; 5 (2). 141-6
Featherstone DE , Broadie K , Wrestling with pleiotropy: genomic and topological analysis of the yeast gene expression network. BioEssays : news and reviews in molecular, cellular and developmental biology. 2002 Mar ; 24 (3). 267-74
Rohrbough J , Broadie K , Electrophysiological analysis of synaptic transmission in central neurons of Drosophila larvae. Journal of neurophysiology. 2002 Aug ; 88 (2). 847-60

Zhang YQ , Rodesch CK , Broadie K , Living synaptic vesicle marker: synaptotagmin-GFP. Genesis (New York, N.Y. : 2000). ; 34 (1-2). 142-5

1995

Schulze KL , Broadie K , Perin MS , Bellen HJ , Genetic and electrophysiological studies of Drosophila syntaxin-1A demonstrate its role in nonneuronal secretion and neurotransmission. Cell. 1995 Jan 27; 80 (2). 311-20
Sweeney ST , Broadie K , Keane J , Niemann H , O'Kane CJ , Targeted expression of tetanus toxin light chain in Drosophila specifically eliminates synaptic transmission and causes behavioral defects. Neuron. 1995 Feb ; 14 (2). 341-51
Broadie Kendal , Bate Michael , The Drosophila NMJ: a genetic model system for synapse formation and function Seminars in Developmental Biology. 1995 ; 6 (3). 221-231
Auld VJ , Fetter RD , Broadie K , Goodman CS , Gliotactin, a novel transmembrane protein on peripheral glia, is required to form the blood-nerve barrier in Drosophila. Cell. 1995 Jun 2; 81 (5). 757-67
Broadie KS , Genetic dissection of the molecular mechanisms of transmitter vesicle release during synaptic transmission. Journal of physiology, Paris. 1995 ; 89 (2). 59-70
Bate M , Broadie K , Wiring by fly: the neuromuscular system of the Drosophila embryo. Neuron. 1995 Sep ; 15 (3). 513-25
Broadie K , Prokop A , Bellen HJ , O'Kane CJ , Schulze KL , Sweeney ST , Syntaxin and synaptobrevin function downstream of vesicle docking in Drosophila. Neuron. 1995 Sep ; 15 (3). 663-73

1996

Keshishian H , Broadie K , Chiba A , Bate M , The drosophila neuromuscular junction: a model system for studying synaptic development and function. Annual review of neuroscience. 1996 ; 19 545-75
Broadie Kendal , Molecular mechanisms of neurotransmitter release: Regulation of the synaptic vesicle cycle in Drosophila Biochemical Society Transactions. 1996 ; 24 639-645
Prokop A , Landgraf M , Rushton E , Broadie K , Bate M , Presynaptic development at the Drosophila neuromuscular junction: assembly and localization of presynaptic active zones. Neuron. 1996 Oct ; 17 (4). 617-26
Baumgartner S , Littleton JT , Broadie K , Bhat MA , Harbecke R , Lengyel JA , Chiquet-Ehrismann R , Prokop A , Bellen HJ , A Drosophila neurexin is required for septate junction and blood-nerve barrier formation and function. Cell. 1996 Dec 13; 87 (6). 1059-68

1997

Broadie K , Rushton E , Skoulakis EM , Davis RL , Leonardo, a Drosophila 14-3-3 protein involved in learning, regulates presynaptic function. Neuron. 1997 Aug ; 19 (2). 391-402

1998

Broadie K , Forward and reverse genetic approaches to synaptogenesis. Current opinion in neurobiology. 1998 Feb ; 8 (1). 128-38

1999

Broadie KS , Development of electrical properties and synaptic transmission at the embryonic neuromuscular junction. International review of neurobiology. 1999 ; 43 45-67
Rohrbough J , Pinto S , Mihalek RM , Tully T , Broadie K , latheo, a Drosophila gene involved in learning, regulates functional synaptic plasticity. Neuron. 1999 May ; 23 (1). 55-70

2000

Broadie Kendal , Electrophysiological approaches to the neuromusculature 2000 ; 273-296
Broadie Kendal , Functional assays of the peripheral and central nervous systems 2000 ;

1999

Zhang YQ , Broadie K , Cloning, mapping and tissue-specific expression of Drosophila clathrin-associated protein AP50 gene. Gene. 1999 Jun 11; 233 (1-2). 171-9
Fergestad T , Davis WS , Broadie K , The stoned proteins regulate synaptic vesicle recycling in the presynaptic terminal. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1999 Jul 15; 19 (14). 5847-60
Wu MN , Fergestad T , Lloyd TE , He Y , Broadie K , Bellen HJ , Syntaxin 1A interacts with multiple exocytic proteins to regulate neurotransmitter release in vivo. Neuron. 1999 Jul ; 23 (3). 593-605

1990

Broadie KS , Sylwester AW , Bate M , Tublitz NJ , Immunological, biochemical and physiological analyses of cardioacceleratory peptide 2 (CAP2) activity in the embryo of the tobacco hawkmoth Manduca sexta. Development (Cambridge, England). 1990 Jan ; 108 (1). 59-71

1991

Broadie Kendal , Bradshaw William , Mechanisms of interference competition in the western tree-hole mosquito, Aedes sierrensis Ecological Entomology. 1991 Mar 14; 16 (2). 145-154
Broadie KS , Bate , Tublitz Nathan , Quantitative staging of embryonic development of the tobacco hawkmoth, Manduca sexta Roux's Archives of Developmental Biology. 1991 ; (199). 327-334
Tublitz N , Brink D , Broadie KS , Loi PK , Sylwester AW , From behavior to molecules: an integrated approach to the study of neuropeptides. Trends in neurosciences. 1991 Jun ; 14 (6). 254-9
Broadie KS , Bate M , The development of adult muscles in Drosophila: ablation of identified muscle precursor cells. Development (Cambridge, England). 1991 Sep ; 113 (1). 103-18

1992

Broadie Kendal , Bate Michael , Embryonic development of the neuromuscular junction of Drosophila Molecular Biology of the Cell. 1992 ; (3). 254
Broadie Kendal , Skaer Helen , Bate Michael , Whole-embryo culture of Drosophila: development of embryonic tissues in vitro Roux's Archive of Developmental Biology. 1992 Jun 10; 201 364-375

1993

Broadie KS , Bate M , Development of the embryonic neuromuscular synapse of Drosophila melanogaster. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1993 Jan ; 13 (1). 144-66
Broadie KS , Bate M , Development of larval muscle properties in the embryonic myotubes of Drosophila melanogaster. The Journal of neuroscience : the official journal of the Society for Neuroscience. 1993 Jan ; 13 (1). 167-80
Broadie K , Bate M , Innervation directs receptor synthesis and localization in Drosophila embryo synaptogenesis. Nature. 1993 Jan ; 361 (6410). 350-3
Broadie K , Bate M , Muscle development is independent of innervation during Drosophila embryogenesis. Development (Cambridge, England). 1993 Oct ; 119 (2). 533-43
Broadie K , Bate M , Activity-dependent development of the neuromuscular synapse during Drosophila embryogenesis. Neuron. 1993 Oct ; 11 (4). 607-19
Broadie Kendal , Development of the Neuromuscular Junction in the Embryo of Drosophila melanogaster University of Cambridge PhD Thesis. 1993 ;
Broadie K , Sink H , Van Vactor D , Fambrough D , Whitington PM , Bate M , Goodman CS , From growth cone to synapse: the life history of the RP3 motor neuron. Development (Cambridge, England). Supplement. 1993 ; 227-38

1994

Meadows LA , Gell D , Broadie K , Gould AP , White RA , The cell adhesion molecule, connectin, and the development of the Drosophila neuromuscular system. Journal of cell science. 1994 Jan ; 107 ( Pt 1) 321-8
Broadie KS , Synaptogenesis in Drosophila: coupling genetics and electrophysiology. Journal of physiology, Paris. 1994 ; 88 (2). 123-39
Harrison SD , Broadie K , van de Goor J , Rubin GM , Mutations in the Drosophila Rop gene suggest a function in general secretion and synaptic transmission. Neuron. 1994 Sep ; 13 (3). 555-66
Hoch M , Broadie K , Jäckle H , Skaer H , Sequential fates in a single cell are established by the neurogenic cascade in the Malpighian tubules of Drosophila. Development (Cambridge, England). 1994 Dec ; 120 (12). 3439-50
Broadie K , Bellen HJ , DiAntonio A , Littleton JT , Schwarz TL , Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 1994 Oct 25; 91 (22). 10727-31

1995

Broadie Kendal , The Drosophila neuromuscular synapse: A genetic model for synapse development and function Invertebrate Neuroscience - the Cutting Edge of Biomedical Research. Elsevier, Tokyo. 1995 ;