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Proteasome function is required to maintain muscle cellular architecture.


AUTHORS

Haas KF , Woodruff E , Broadie K , . Biology of the cell / under the auspices of the European Cell Biology Organization. 2007 11 ; 99(11). 615-26

ABSTRACT

Protein degradation via the UPS (ubiquitin-proteasome system) plays critical roles in muscle metabolism and signalling pathways. The present study investigates temporal requirements of the UPS in muscle using conditional expression of mutant proteasome beta subunits to cause targeted inhibition of proteasome function.


Protein degradation via the UPS (ubiquitin-proteasome system) plays critical roles in muscle metabolism and signalling pathways. The present study investigates temporal requirements of the UPS in muscle using conditional expression of mutant proteasome beta subunits to cause targeted inhibition of proteasome function.


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