Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry.
AUTHORS
Bachmann
BOBrian O ,
McNees
R Ruth ,
Melancon
BJ Bruce J ,
Ghidu
VP Victor P ,
Clark
R Rachel ,
Crews
BC Brenda C ,
Deguire
SM Sean M ,
Marnett
LJ Lawrence J ,
Sulikowski
GA Gary A .
Organic letters. 2010 7 2; 12(13).
2944-7
- PMID: 20515014[PubMed].
- PMCID: PMC2905629.
- NIHMSID: NIHMS210444
ABSTRACT
The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2-C3 carbon-carbon double bond of apoptolidin A.
The isolation, characterization, and cytotoxicity against H292 cells of apoptolidin G are reported. Apoptolidin G is shown to be derived by a light-induced isomerization of the C2-C3 carbon-carbon double bond of apoptolidin A.