A new multi-gram synthetic route to labeling precursors for the D(2/3) PET agent 18F-fallypride.
AUTHORS
Kim
KKwangho ,
Miller
NR Nicole R ,
Sulikowski
GA Gary A ,
Lindsley
CW Craig W .
Bioorganic & medicinal chemistry letters. 2008 8 15; 18(16).
4467-9
- PMID: 18674906[PubMed].
- PMCID: PMC3177602.
- NIHMSID: NIHMS66496
ABSTRACT
This Letter describes a new multi-gram synthetic protocol for the preparation of the classic tosylate labeling precursor for the D(2/3) PET agent [(18)F]fallypride. In the course of our studies, we also discovered two novel labeling precusors, the previously undescribed mesylate and chloro congeners of fallypride.
This Letter describes a new multi-gram synthetic protocol for the preparation of the classic tosylate labeling precursor for the D(2/3) PET agent [(18)F]fallypride. In the course of our studies, we also discovered two novel labeling precusors, the previously undescribed mesylate and chloro congeners of fallypride.