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Jacobson Lab

Jacobson Lab Publications

2023

Nakhe AY , Dadi PK , Kim J , Shrestha S , Cartailler JP , Sampson L , Magnuson MA , Jacobson DA , The MODY-associated TALK-1 L114P mutation causes islet α-cell overactivity and β-cell inactivity resulting in transient neonatal diabetes and glucose dyshomeostasis in adults bioRxiv : the preprint server for biology. 2023 Jul 26;
Nakhe AY , Jacobson DA , IPRs puff along: A SNAPpy dance with IP and Ca The Journal of biological chemistry. 2023 Feb 10; 299 (3). 103010

2022

Zaborska KE , Jordan KL , Thorson AS , Dadi PK , Schaub CM , Nakhe AY , Dickerson MT , Lynch JC , Weiss AJ , Dobson JR , Jacobson DA , Liraglutide increases islet Ca oscillation frequency and insulin secretion by activating hyperpolarization-activated cyclic nucleotide-gated channels Diabetes, obesity & metabolism. 2022 May 30; 24 (9). 1741-1752
Dickerson MT , Dadi PK , Zaborska KE , Nakhe AY , Schaub CM , Dobson JR , Wright NM , Lynch JC , Scott CF , Robinson LD , Jacobson DA , G protein-coupled receptor inhibition of beta-cell electrical excitability and insulin secretion depends on Na/K ATPase activation Nature communications. 2022 Oct 29; 13 (1). 6461
Rahim M , Nakhe AY , Banerjee DR , Overway EM , Bosma KJ , Rosch JC , Oeser JK , Wang B , Lippmann ES , Jacobson DA , O'Brien RM , Young JD , Glucose-6-phosphatase catalytic subunit 2 negatively regulates glucose oxidation and insulin secretion in pancreatic β-cells The Journal of biological chemistry. 2022 Feb 15; 298 (4). 101729
Cheung R , Pizza G , Chabosseau P , Rolando D , Tomas A , Burgoyne T , Wu Z , Salowka A , Tapa A , Macklin A , Cao Y , Nguyen-Tu MS , Dickerson MT , Jacobson DA , Marchetti P , Shapiro J , Piemonti L , de Koning E , Leclerc I , Bouzakri K , Sakamoto K , Smith DM , Rutter GA , Martinez-Sanchez A , Glucose-Dependent miR-125b is a Negative Regulator of β-Cell Function Diabetes. 2022 Apr 27;

2021

Mousavy Gharavy SN , Owen BM , Millership SJ , Chabosseau P , Pizza G , Martinez-Sanchez A , Tasoez E , Georgiadou E , Hu M , Fine NHF , Jacobson DA , Dickerson MT , Idevall-Hagren O , Montoya A , Kramer H , Mehta Z , Withers DJ , Ninov N , Gadue PJ , Cardenas-Diaz FL , Cruciani-Guglielmacci C , Magnan C , Ibberson M , Leclerc I , Voz M , Rutter GA , Sexually dimorphic roles for the type 2 diabetes-associated C2cd4b gene in murine glucose homeostasis Diabetologia. 2021 Jan 25; 64 (4). 850-864
Sanavia T , Huang C , Manduchi E , Xu Y , Dadi PK , Potter LA , Jacobson DA , Di Camillo B , Magnuson MA , Stoeckert CJ , Gu G , Temporal Transcriptome Analysis Reveals Dynamic Gene Expression Patterns Driving β-Cell Maturation Frontiers in cell and developmental biology. 2021 May 04; 9 648791
Kuo T , Du W , Miyachi Y , Dadi PK , Jacobson DA , Segrè D , Accili D , Antagonistic epistasis of Hnf4α and FoxO1 metabolic networks through enhancer interactions in β-cell function Molecular metabolism. 2021 May 25; 53 101256
Graff SM , Johnson SR , Leo PJ , Dadi PK , Dickerson MT , Nakhe AY , McInerney-Leo AM , Marshall M , Zaborska KE , Schaub CM , Brown MA , Jacobson DA , Duncan EL , A KCNK16 mutation causing TALK-1 gain of function is associated with maturity-onset diabetes of the young JCI insight. 2021 Jul 08; 6 (13).
West JD , Austin ED , Rizzi EM , Yan L , Tanjore H , Crabtree AL , Moore CS , Muthian G , Carrier EJ , Jacobson DA , Hamid R , Kendall PL , Majka S , Rathinasabapathy A , KCNK3 Mutation Causes Altered Immune Function in Pulmonary Arterial Hypertension Patients and Mouse Models International journal of molecular sciences. 2021 May 09; 22 (9).
Dickerson MT , Jacobson DA , Channeling β-cell Maturity: KATP Surface Localization Imparts Glucose Sensing Endocrinology. 2021 ; 162 (11).
Altman MK , Schaub CM , Dadi PK , Dickerson MT , Zaborska KE , Nakhe AY , Graff SM , Galletta TJ , Amarnath G , Thorson AS , Gu G , Jacobson DA , TRPM7 is a crucial regulator of pancreatic endocrine development and high-fat-diet-induced β-cell proliferation Development (Cambridge, England). 2021 Aug 16; 148 (16).

2020

Yang X , Graff SM , Heiser CN , Ho KH , Chen B , Simmons AJ , Southard-Smith AN , David G , Jacobson DA , Kaverina I , Wright CVE , Lau KS , Gu G , Coregulator Sin3a Promotes Postnatal Murine β-Cell Fitness by Regulating Genes in Ca Homeostasis, Cell Survival, Vesicle Biosynthesis, Glucose Metabolism, and Stress Response Diabetes. 2020 Apr 03; 69 (6). 1219-1231
Georgiadou E , Haythorne E , Dickerson MT , Lopez-Noriega L , Pullen TJ , da Silva Xavier G , Davis SPX , Martinez-Sanchez A , Semplici F , Rizzuto R , McGinty JA , French PM , Cane MC , Jacobson DA , Leclerc I , Rutter GA , The pore-forming subunit MCU of the mitochondrial Ca uniporter is required for normal glucose-stimulated insulin secretion in vitro and in vivo in mice Diabetologia. 2020 Apr 29; 63 (7). 1368-1381
Lengyel M , Czirják G , Jacobson DA , Enyedi P , TRESK and TREK-2 two-pore-domain potassium channel subunits form functional heterodimers in primary somatosensory neurons The Journal of biological chemistry. 2020 Jul 07; 295 (35). 12408-12425
Zaborska KE , Dadi PK , Dickerson MT , Nakhe AY , Thorson AS , Schaub CM , Graff SM , Stanley JE , Kondapavuluru RS , Denton JS , Jacobson DA , Lactate activation of α-cell K channels inhibits glucagon secretion by hyperpolarizing the membrane potential and reducing Ca entry Molecular metabolism. 2020 Jul 28; 42 101056
Dickerson MT , Dadi PK , Butterworth RB , Nakhe AY , Graff SM , Zaborska KE , Schaub CM , Jacobson DA , Tetraspanin-7 regulation of L-type voltage-dependent calcium channels controls pancreatic β-cell insulin secretion The Journal of physiology. 2020 Sep 01; 598 (21). 4887-4905
Yang B , Maddison LA , Zaborska KE , Dai C , Yin L , Tang Z , Zang L , Jacobson DA , Powers AC , Chen W , RIPK3-mediated inflammation is a conserved β cell response to ER stress Science advances. 2020 Dec 18; 6 (51).
Perfitt TL , Wang X , Dickerson MT , Stephenson JR , Nakagawa T , Jacobson DA , Colbran RJ , Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction The Journal of neuroscience : the official journal of the Society for Neuroscience. 2020 Feb 03;

2019

Kharade SV , Sanchez-Andres JV , Fulton MG , Shelton EL , Blobaum AL , Engers DW , Hofmann CS , Dadi PK , Lantier L , Jacobson DA , Lindsley CW , Denton JS , Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063 The Journal of pharmacology and experimental therapeutics. 2019 Jun 14; 370 (3). 350-359
Jacobson DA , Shyng SL , Ion Channels of the Islets in Type 2 Diabetes Journal of molecular biology. 2019 Aug 30;
Liu J , Banerjee A , Herring CA , Attalla J , Hu R , Xu Y , Shao Q , Simmons AJ , Dadi PK , Wang S , Jacobson DA , Liu B , Hodges E , Lau KS , Gu G , Neurog3-Independent Methylation Is the Earliest Detectable Mark Distinguishing Pancreatic Progenitor Identity Developmental cell. 2019 Jan 7; 48 (1). 49-63.e7
Dickerson MT , Dadi PK , Altman MK , Verlage KR , Thorson AS , Jordan KL , Vierra NC , Amarnath G , Jacobson DA , Glucose-mediated inhibition of calcium-activated potassium channels limits alpha-cell calcium influx and glucagon secretion American journal of physiology. Endocrinology and metabolism. 2019 Jan 29;

2018

Navarro G , Allard C , Morford JJ , Xu W , Liu S , Molinas AJ , Butcher SM , Fine NHF , Blandino-Rosano M , Sure VN , Yu S , Zhang R , Münzberg H , Jacobson DA , Katakam PV , Hodson DJ , Bernal-Mizrachi E , Zsombok A , Mauvais-Jarvis F , Androgen excess in pancreatic β cells and neurons predisposes female mice to type 2 diabetes JCI insight. 2018 Jun 21; 3 (12).
Vierra NC , Dickerson MT , Philipson LH , Jacobson DA , Simultaneous Real-Time Measurement of the β-Cell Membrane Potential and Ca2+ Influx to Assess the R… Methods in molecular biology (Clifton, N.J.). 2018 ; 1684 73-84
Dickerson MT , Bogart AM , Altman MK , Milian SC , Jordan KL , Dadi PK , Jacobson DA , Cytokine-mediated changes in K+ channel activity promotes an adaptive Ca2+ response that sustains β… Scientific reports. 2018 Jan 18; 8 (1). 1158
Vierra NC , Dickerson MT , Jordan KL , Dadi PK , Kadare KA , Altman MK , Milian SC , Jacobson DA , TALK-1 reduces delta-cell endoplasmic reticulum and cytoplasmic calcium levels limiting somatostatin… Molecular metabolism. 2018 Jan 31;
Huang C , Walker EM , Dadi PK , Hu R , Xu Y , Zhang W , Sanavia T , Mun J , Liu J , Nair GG , Tan HYA , Wang S , Magnuson MA , Stoeckert CJ , Hebrok M , Gannon M , Han W , Stein R , Jacobson DA , Gu G , Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin … Developmental cell. 2018 Apr 12;
Hart NJ , Aramandla R , Poffenberger G , Fayolle C , Thames AH , Bautista A , Spigelman AF , Babon JAB , DeNicola ME , Dadi PK , Bush WS , Balamurugan AN , Brissova M , Dai C , Prasad N , Bottino R , Jacobson DA , Drumm ML , Kent SC , MacDonald PE , Powers AC , Cystic fibrosis-related diabetes is caused by islet loss and inflammation. JCI insight. 2018 Apr 19; 3 (8).

2017

Stancill JS , Cartailler JP , Clayton HW , O'Connor JT , Dickerson MT , Dadi PK , Osipovich AB , Jacobson DA , Magnuson MA , Chronic β-Cell Depolarization Impairs β-Cell Identity by Disrupting a Network of Ca(2+)-Regulated … Diabetes. 2017 May 26;
Dickerson MT , Vierra NC , Milian SC , Dadi PK , Jacobson DA , Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells. PloS one. 2017 ; 12 (4). e0175069
Zhu L , Almaça J , Dadi PK , Hong H , Sakamoto W , Rossi M , Lee RJ , Vierra NC , Lu H , Cui Y , McMillin SM , Perry NA , Gurevich VV , Lee A , Kuo B , Leapman RD , Matschinsky FM , Doliba NM , Urs NM , Caron MG , Jacobson DA , Caicedo A , Wess J , β-arrestin-2 is an essential regulator of pancreatic β-cell function under physiological and patho… Nature communications. 2017 Feb 1; 8 14295
Wang X , Marks CR , Perfitt TL , Nakagawa T , Lee A , Jacobson DA , Colbran RJ , A novel mechanism for Ca(2+)/calmodulin-dependent protein kinase II targeting to L-type Ca(2+) chann… The Journal of biological chemistry. 2017 Sep 15;
Vierra NC , Dadi PK , Milian SC , Dickerson MT , Jordan KL , Gilon P , Jacobson DA , TALK-1 channels control β cell endoplasmic reticulum Ca(2+) homeostasis. Science signaling. 2017 Sep 19; 10 (497).
Fine NHF , Doig CL , Elhassan YS , Vierra NC , Marchetti P , Bugliani M , Nano R , Piemonti L , Rutter GA , Jacobson DA , Lavery GG , Hodson DJ , Glucocorticoids Reprogram Beta Cell Signaling to Preserve Insulin Secretion. Diabetes. 2017 Dec 4;

2016

Navarro G , Xu W , Jacobson DA , Wicksteed B , Allard C , Zhang G , De Gendt K , Kim SH , Wu H , Zhang H , Verhoeven G , Katzenellenbogen JA , Mauvais-Jarvis F , Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Ma… Cell metabolism. 2016 Apr 26;
Boortz KA , Syring KE , Dai C , Pound LD , Oeser JK , Jacobson DA , Wang JC , McGuinness OP , Powers AC , O'Brien RM , G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress. Endocrinology. 2016 Jun 14; en20161245
Dadi PK , Vierra NC , Days EL , Dickerson M , Vinson PN , Weaver CD , Jacobson DA , Selective small molecule activators of TREK-2 channels stimulate DRG c-fiber nociceptor K2P currents… ACS chemical neuroscience. 2016 Nov 2;

2015

Dadi PK , Luo B , Vierra NC , Jacobson DA , TASK-1 potassium channels limit pancreatic alpha-cell calcium influx and glucagon secretion. Molecular endocrinology (Baltimore, Md.). 2015 Apr 7; me20141321
Golson ML , Dunn JC , Maulis MF , Dadi PK , Osipovich AB , Magnuson MA , Jacobson DA , Gannon M , Activation of FoxM1 revitalizes the replicative potential of aged β -cells in male mice and enhance… Diabetes. 2015 Aug 6;
Vierra NC , Dadi PK , Jeong I , Dickerson M , Powell DR , Jacobson DA , The type-2 diabetes-associated K+ channel TALK-1 modulates beta-cell electrical excitability, 2nd-ph… Diabetes. 2015 Aug 3;

2014

Egnatchik RA , Leamy AK , Jacobson DA , Shiota M , Young JD , ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to p… Molecular metabolism. 2014 Aug ; 3 (5). 544-53
Raphemot R , Swale DR , Dadi PK , Jacobson DA , Cooper P , Wojtovich AP , Banerjee S , Nichols CG , Denton JS , Direct Activation of β-Cell KATP Channels with a Novel Xanthine Derivative. Molecular pharmacology. 2014 Jun ; 85 (6). 858-65
Dadi PK , Vierra NC , Ustione A , Piston DW , Colbran RJ , Jacobson DA , Inhibition of Pancreatic β-Cell Ca2+/Calmodulin-dependent Protein Kinase II Reduces Glucose-stimula… The Journal of biological chemistry. 2014 May 2; 289 (18). 12435-45
Egnatchik A. , Leamy K. , Jacobson A. , Shiota , Young D. , ER calcium release promotes mitochondrial dysfunction and hepatic cell lipotoxicity in response to p… molecular metabolism. 2014 May 23; 4 (4).
Dadi PK , Vierra NC , Jacobson DA , Pancreatic beta-cell specific ablation of TASK-1 channels augments glucose-stimulated calcium entry … Endocrinology. 2014 Jun 16; en20132051

2013

Fridlyand LE , Jacobson DA , Philipson LH , Ion channels and regulation of insulin secretion in human β-cells: a computational systems analysis… Islets. 2013 ; 5 (1). 1-15
Baerenwald DA , Bonnefond A , Bouatia-Naji N , Flemming BP , Umunakwe OC , Oeser JK , Pound LD , Conley NL , Cauchi S , Lobbens S , Eury E , Balkau B , Lantieri O , , Dadi PK , Jacobson DA , Froguel P , O'Brien RM , Multiple functional polymorphisms in the G6PC2 gene contribute to the association with higher fastin… Diabetologia. 2013 Jun ; 56 (6). 1306-16
Kaihara KA , Dickson LM , Jacobson DA , Tamarina N , Roe MW , Philipson LH , Wicksteed B , β-Cell-specific protein kinase A activation enhances the efficiency of glucose control by increasin… Diabetes. 2013 May ; 62 (5). 1527-36
Pound LD , Oeser JK , O'Brien TP , Wang Y , Faulman CJ , Dadi PK , Jacobson DA , Hutton JC , McGuinness OP , Shiota M , O'Brien RM , G6PC2: a negative regulator of basal glucose-stimulated insulin secretion. Diabetes. 2013 May ; 62 (5). 1547-56

2012

Pound LD , Sarkar SA , Ustione A , Dadi PK , Shadoan MK , Lee CE , Walters JA , Shiota M , McGuinness OP , Jacobson DA , Piston DW , Hutton JC , Powell DR , O'Brien RM , The physiological effects of deleting the mouse SLC30A8 gene encoding zinc transporter-8 are influen… PloS one. 2012 ; 7 (7). e40972
Denton JS , Jacobson DA , Channeling dysglycemia: ion-channel variations perturbing glucose homeostasis. Trends in endocrinology and metabolism: TEM. 2012 Jan ; 23 (1). 41-8

2010

Jacobson DA , Mendez F , Thompson M , Torres J , Cochet O , Philipson LH , Calcium-activated and voltage-gated potassium channels of the pancreatic islet impart distinct and c… The Journal of physiology. 2010 Sep 15; 588 (Pt 18). 3525-37

2009

Deriy LV , Gomez EA , Jacobson DA , Wang X , Hopson JA , Liu XY , Zhang G , Bindokas VP , Philipson LH , Nelson DJ , The granular chloride channel ClC-3 is permissive for insulin secretion. Cell metabolism. 2009 Oct ; 10 (4). 316-23
Fridlyand LE , Jacobson DA , Kuznetsov A , Philipson LH , A model of action potentials and fast Ca2+ dynamics in pancreatic beta-cells. Biophysical journal. 2009 Apr 22; 96 (8). 3126-39
Jacobson DA , Wicksteed BL , Philipson LH , The alpha-cell conundrum: ATP-sensitive K+ channels and glucose sensing. Diabetes. 2009 Feb ; 58 (2). 304-6

2008

Bao S , Jacobson DA , Wohltmann M , Bohrer A , Jin W , Philipson LH , Turk J , Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2beta i… American journal of physiology. Endocrinology and metabolism. 2008 Feb ; 294 (2). E217-29

2007

Jacobson DA , Philipson LH , Action potentials and insulin secretion: new insights into the role of Kv channels. Diabetes, obesity & metabolism. 2007 Nov ; 9 Suppl 2 89-98
Jacobson DA , Kuznetsov A , Lopez JP , Kash S , Ammälä CE , Philipson LH , Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretion. Cell metabolism. 2007 Sep ; 6 (3). 229-35
Jacobson DA , Philipson LH , TRP channels of the pancreatic beta cell. Handbook of experimental pharmacology. 2007 ; (179). 409-24
Jacobson DA , Weber CR , Bao S , Turk J , Philipson LH , Modulation of the pancreatic islet beta-cell-delayed rectifier potassium channel Kv2.1 by the polyun… The Journal of biological chemistry. 2007 Mar 9; 282 (10). 7442-9

2006

Jacobson DA , Cho J , Landa LR , Tamarina NA , Roe MW , Buxbaum JD , Philipson LH , Downstream regulatory element antagonistic modulator regulates islet prodynorphin expression. American journal of physiology. Endocrinology and metabolism. 2006 Sep ; 291 (3). E587-95

Walker EM , Cha J , Tong X , Guo M , Liu JH , Yu S , Iacovazzo D , Mauvais-Jarvis F , Flanagan SE , Korbonits M , Stafford J , Jacobson DA , Stein R , Sex-biased islet β cell dysfunction is caused by the MODY MAFA S64F variant by inducing premature aging and senescence in males Cell reports. ; 37 (2). 109813
Dai C , Walker JT , Shostak A , Bouchi Y , Poffenberger G , Hart NJ , Jacobson DA , Calcutt MW , Bottino R , Greiner DL , Shultz LD , McGuinness OP , Dean ED , Powers AC , Dapagliflozin Does Not Directly Affect Human α or β Cells Endocrinology. ; 161 (8).
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