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IPRs puff along: A SNAPpy dance with IP and Ca


Nakhe AYArya Y , Jacobson DADavid A . The Journal of biological chemistry. 2023 02 10; 299(3). 103010


Concerted openings of clustered inositol 1,4,5-trisphosphate receptors (IPRs) result in short, localized Ca bursts, also called puffs, which are crucial regulators of Ca-dependent signaling processes. However, the processes regulating Ca puff amplitude (average ∼0.5 ΔF/F) and duration (at half-maximal; average ∼25-30 ms) have yet to be elucidated. A recent study in JBC by Smith and Taylor determined that Ca puff amplitude is independent of IPR cluster density and that the termination of IPR Ca puff is regulated by IP dissociation, illuminating the steps of this regulatory dance.