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Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans


Sundararajan LLakshmi , Stern JJamie , Miller DMDavid M . Developmental Biology. 2019 4 17; 451(1). 53-67


The shape of an individual neuron is linked to its function with axons sending signals to other cells and dendrites receiving them. Although much is known of the mechanisms for axonal outgrowth, the striking complexity of dendritic architecture has hindered efforts to uncover pathways that direct dendritic branching. Here we review the results of an experimental strategy that exploits the power of genetic analysis and live cell imaging of the PVD sensory neuron in C. elegans to reveal key molecular drivers of dendrite morphogenesis.