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Miller Lab

Food Sensation Modulates Locomotion by Dopamine and Neuropeptide Signaling in a Distributed Neuronal Network

AUTHORS

Oranth AAlexandra , Schultheis CChristian , Tolstenkov OOleg , Erbguth KKaren , Nagpal JJatin , Hain DDavid , Brauner MMartin , Wabnig SSebastian , Steuer Costa WWagner , McWhirter RDRebecca D , Zels SSven , Palumbos SSierra , Miller Iii DMDavid M , Beets IIsabel , Gottschalk AAlexander . Neuron. 2018 11 01; 100(6). 1414-1428.e10

ABSTRACT

Finding food and remaining at a food source are crucial survival strategies. We show how neural circuits and signaling molecules regulate these food-related behaviors in Caenorhabditis elegans. In the absence of food, AVK interneurons release FLP-1 neuropeptides that inhibit motorneurons to regulate body posture and velocity, thereby promoting dispersal. Conversely, AVK photoinhibition promoted dwelling behavior. We identified FLP-1 receptors required for these effects in distinct motoneurons. The DVA interneuron antagonizes signaling from AVK by releasing cholecystokinin-like neuropeptides that potentiate cholinergic neurons, in response to dopaminergic neurons that sense food. Dopamine also acts directly on AVK via an inhibitory dopamine receptor. Both AVK and DVA couple to head motoneurons by electrical and chemical synapses to orchestrate either dispersal or dwelling behavior, thus integrating environmental and proprioceptive signals. Dopaminergic regulation of food-related behavior, via similar neuropeptides, may be conserved in mammals.