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Magnuson Lab

Ca signaling and metabolic stress-induced pancreatic β-cell failure

AUTHORS

Magnuson MAMark A , Osipovich ABAnna B . Frontiers in Endocrinology. 2024 7 2; 15(). 1412411

ABSTRACT

Early in the development of Type 2 diabetes (T2D), metabolic stress brought on by insulin resistance and nutrient overload causes β-cell hyperstimulation. Herein we summarize recent studies that have explored the premise that an increase in the intracellular Ca concentration ([Ca]), brought on by persistent metabolic stimulation of β-cells, causes β-cell dysfunction and failure by adversely affecting β-cell function, structure, and identity. This mini-review builds on several recent reviews that also describe how excess [Ca] impairs β-cell function.

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