Eukaryotic cells accomplish cell division with exquisite spatial and temporal control. A key event during cell division is the formation of an actin- and myosin-based contractile ring that constricts to physically separate two new daughter cells. Our lab is fascinated with how chromosome segregation and cytokinesis are coordinated to ensure genomic integrity and the molecular details of how the contractile ring is formed and organized. To study these topics, we employ a powerful combination of experimental techniques including sophisticated super-resolution imaging, biochemical reconstitution, structural biology, proteomics/mass spectrometry and genetics.
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We are members of the Department of Cell and Developmental Biology at Vanderbilt University in Nashville, TN. For more information about our institution and life in Nashville, visit our links or Contact Us.