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Broadie Laboratory

The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy.

AUTHORS

Speese SDSean D , Trotta N Nick , Rodesch CK Chris K , Aravamudan B Bharathi , Broadie K Kendal . Current biology : CB. 2003 5 27; 13(11). 899-910

ABSTRACT

The ubiquitin proteasome system (UPS) mediates regulated protein degradation and provides a mechanism for closely controlling protein abundance in spatially restricted domains within cells. We hypothesized that the UPS may acutely determine the local concentration of key regulatory proteins at neuronal synapses as a means for locally modulating synaptic efficacy and the strength of neurotransmission communication.

The ubiquitin proteasome system (UPS) mediates regulated protein degradation and provides a mechanism for closely controlling protein abundance in spatially restricted domains within cells. We hypothesized that the UPS may acutely determine the local concentration of key regulatory proteins at neuronal synapses as a means for locally modulating synaptic efficacy and the strength of neurotransmission communication.

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