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Weaver Lab

Weaver Lab Publications

2018

Abney KK , Ramos-Hunter SJ , Romaine IM , Goodwin JS , Sulikowski GA , Weaver CD , Selective Activation of N,N’-Diacyl Rhodamine Pro-fluorophores Paired with Releasing Enzyme, Porcine Liver Esterase (PLE) Chemistry (Weinheim an der Bergstrasse, Germany). 2018 May 25; 24 (36). 8985-8988
Kharade SV , Kurata H , Bender AM , Blobaum AL , Figueroa EE , Duran A , Kramer M , Days E , Vinson P , Flores D , Satlin LM , Meiler J , Weaver CD , Lindsley CW , Hopkins CR , Denton JS , Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992 Molecular pharmacology. 2018 Jun 12; 94 (2). 926-937
Dutter BF , Ender A , Sulikowski GA , Weaver CD , Rhodol-based thallium sensors for cellular imaging of potassium channel activity Organic & biomolecular chemistry. 2018 Jul 27;

2017

Nance KD , Days EL , Weaver CD , Coldren A , Farmer TD , Cho HP , Niswender CM , Blobaum AL , Niswender KD , Lindsley CW , Discovery of a Novel Series of Orally Bioavailable and CNS Penetrant Glucagon-like Peptide-1 Receptor (GLP-1R) Noncompetitive Antagonists Based on a 1,3-Disubstituted-7-aryl-5,5-bis(trifluoromethyl)-5,8-dihydropyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione Core Journal of medicinal chemistry. 2017 Feb 03; 60 (4). 1611-1616
Azumaya CM , Days EL , Vinson PN , Stauffer S , Sulikowski G , Weaver CD , Nakagawa T , Screening for AMPA receptor auxiliary subunit specific modulators PloS one. 2017 Mar 30; 12 (3). e0174742
Marron Fernandez de Velasco E , Zhang L , N Vo B , Tipps M , Farris S , Xia Z , Anderson A , Carlblom N , Weaver CD , Dudek SM , Wickman K , GIRK2 splice variants and neuronal G protein-gated K channels: implications for channel function and behavior Scientific reports. 2017 May 09; 7 (1). 1639
Wieting JM , Vadukoot AK , Sharma S , Abney KK , Bridges TM , Daniels JS , Morrison RD , Wickman K , Weaver CD , Hopkins CR , Discovery and Characterization of 1H-Pyrazol-5-yl-2-phenylacetamides as Novel, Non-Urea-Containing GIRK1/2 Potassium Channel Activators ACS chemical neuroscience. 2017 Jul 19; 8 (9). 1873-1879
Schubert M , Stichel J , Du Y , Tough IR , Sliwoski G , Meiler J , Cox HM , Weaver CD , Beck-Sickinger AG , Identification and Characterization of the First Selective Y Receptor Positive Allosteric Modulator Journal of medicinal chemistry. 2017 Aug 28; 60 (17). 7605-7612

2016

Dadi PK , Vierra NC , Days E , Dickerson MT , Vinson PN , Weaver CD , Jacobson DA , Selective Small Molecule Activators of TREK-2 Channels Stimulate Dorsal Root Ganglion c-Fiber Nociceptor Two-Pore-Domain Potassium Channel Currents and Limit Calcium Influx ACS chemical neuroscience. 2016 Nov 23; 8 (3). 558-568
Delpire E , Weaver CD , Challenges of Finding Novel Drugs Targeting the K-Cl Cotransporter ACS chemical neuroscience. 2016 Nov 08; 7 (12). 1624-1627
Kim HY , Korade Z , Tallman KA , Liu W , Weaver CD , Mirnics K , Porter NA , Inhibitors of 7-Dehydrocholesterol Reductase: Screening of a Collection of Pharmacologically Active … Chemical research in toxicology. 2016 May 16; 29 (5). 892-900
Sliwoski G , Schubert M , Stichel J , Weaver D , Beck-Sickinger AG , Meiler J , Discovery of Small-Molecule Modulators of the Human Y4 Receptor. PloS one. 2016 ; 11 (6). e0157146
Barber M. , Schönberger , Burgstaller , Levitz , Weaver , Isacoff Y. , Baier , Trauner Dirk , Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO) Chemical Science. 2016 ; (7). 2347-2352

2015

Barber DM , Schönberger M , Burgstaller J , Levitz J , Weaver CD , Isacoff EY , Baier H , Trauner D , Optical control of neuronal activity using a light-operated GIRK channel opener (LOGO) Chemical science. 2015 Nov 23; 7 (3). 2347-2352
Kotecki L , Hearing M , McCall NM , Marron Fernandez de Velasco E , Pravetoni M , Arora D , Victoria NC , Munoz MB , Xia Z , Slesinger PA , Weaver CD , Wickman K , GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2015 May 6; 35 (18). 7131-42
Du Y , Days E , Romaine I , Abney KK , Kaufmann K , Sulikowski G , Stauffer S , Lindsley CW , Weaver CD , Development and Validation of a Thallium Flux-Based Functional Assay for the Sodium Channel NaV1.7 a… ACS chemical neuroscience. 2015 Jun 17; 6 (6). 871-8

2014

Morris LC , Nance KD , Gentry PR , Days EL , Weaver CD , Niswender CM , Thompson AD , Jones CK , Locuson CW , Morrison RD , Daniels JS , Niswender KD , Lindsley CW , Discovery of (S)-2-cyclopentyl-N-((1-isopropylpyrrolidin2-yl)-9-methyl-1-oxo-2,9-dihydro-1H-pyrrido[… Journal of medicinal chemistry. 2014 Dec 11; 57 (23). 10192-7
Glickman JF , Lundbäck T , Napper AD , Niles WD , Simeonov A , Weaver CD , Yin HH , Zaman GJ , Osada H , Controversies in ASSAY and drug development technologies: a focus on assessing irreproducibility. Assay and drug development technologies. 2014 Oct ; 12 (8). 443-51
Raphemot R , Rouhier MF , Swale DR , Days E , Weaver CD , Lovell KM , Konkel LC , Engers DW , Bollinger SF , Hopkins C , Piermarini PM , Denton JS , Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier… PloS one. 2014 ; 9 (11). e110772
Kumar KK , Lowe EW , Aboud AA , Neely MD , Redha R , Bauer JA , Odak M , Weaver CD , Meiler J , Aschner M , Bowman AB , Cellular manganese content is developmentally regulated in human dopaminergic neurons. Scientific reports. 2014 ; 4 6801
Wen W , Wu W , Weaver CD , Lindsley CW , Discovery of potent and selective GIRK1/2 modulators via ‘molecular switches’ within a series of 1-(… Bioorganic & medicinal chemistry letters. 2014 Nov 1; 24 (21). 5102-6
Jalan-Sakrikar N , Field JR , Klar R , Mattmann ME , Gregory KJ , Zamorano R , Engers DW , Bollinger SR , Weaver CD , Days EL , Lewis LM , Utley TJ , Hurtado M , Rigault D , Acher F , Walker AG , Melancon BJ , Wood MR , Lindsley CW , Conn PJ , Xiang Z , Hopkins CR , Niswender CM , Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new… ACS chemical neuroscience. 2014 Dec 17; 5 (12). 1221-37
Wydeven N , Marron Fernandez de Velasco E , Du Y , Benneyworth MA , Hearing MC , Fischer RA , Thomas MJ , Weaver CD , Wickman K , Mechanisms underlying the activation of G-protein-gated inwardly rectifying K+ (GIRK) channels by th… Proceedings of the National Academy of Sciences of the United States of America. 2014 Jul 22; 111 (29). 10755-60
Turlington M , Malosh C , Jacobs J , Manka JT , Noetzel MJ , Vinson PN , Jadhav S , Herman EJ , Lavreysen H , Mackie C , Bartolomé-Nebreda JM , Conde-Ceide S , Martín-Martín ML , Tong HM , López S , MacDonald GJ , Steckler T , Daniels JS , Weaver CD , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Stauffer SR , Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the m… Journal of medicinal chemistry. 2014 Jul 10; 57 (13). 5620-37
Morris LC , Days EL , Turney M , Mi D , Lindsley CW , Weaver CD , Niswender KD , A Duplexed High-Throughput Screen to Identify Allosteric Modulators of the Glucagon-Like Peptide 1 a… Journal of biomolecular screening. 2014 Feb 13; 19 (6). 847-858

2013

Wu YJ , Conway CM , Sun LQ , Machet F , Chen J , Chen P , He H , Bourin C , Calandra V , Polino JL , Davis CD , Heman K , Gribkoff VK , Boissard CG , Knox RJ , Thompson MW , Fitzpatrick W , Weaver D , Harden DG , Natale J , Dworetzky SI , Starrett JE , Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent … Bioorganic & medicinal chemistry letters. 2013 Nov 15; 23 (22). 6188-91
Raphemot R , Kadakia RJ , Olsen ML , Banerjee S , Days E , Smith SS , Weaver CD , Denton JS , Development and validation of fluorescence-based and automated patch clamp-based functional assays f… Assay and drug development technologies. 2013 Nov ; 11 (9-10). 532-43
Gregory KJ , Herman EJ , Ramsey AJ , Hammond AS , Byun NE , Stauffer SR , Manka JT , Jadhav S , Bridges TM , Weaver CD , Niswender CM , Steckler T , Drinkenburg WH , Ahnaou A , Lavreysen H , Macdonald GJ , Bartolomé JM , Mackie C , Hrupka BJ , Caron MG , Daigle TL , Lindsley CW , Conn PJ , Jones CK , N-aryl piperazine metabotropic glutamate receptor 5 positive allosteric modulators possess efficacy … The Journal of pharmacology and experimental therapeutics. 2013 Nov ; 347 (2). 438-57
Bartolomé-Nebreda JM , Conde-Ceide S , Delgado F , Iturrino L , Pastor J , Pena MÁ , Trabanco AA , Tresadern G , Wassvik CM , Stauffer SR , Jadhav S , Gogi K , Vinson PN , Noetzel MJ , Days E , Weaver CD , Lindsley CW , Niswender CM , Jones CK , Conn PJ , Rombouts F , Lavreysen H , Macdonald GJ , Mackie C , Steckler T , Dihydrothiazolopyridone derivatives as a novel family of positive allosteric modulators of the metab… Journal of medicinal chemistry. 2013 Sep 26; 56 (18). 7243-59
Ramos-Hunter SJ , Engers DW , Kaufmann K , Du Y , Lindsley CW , Weaver CD , Sulikowski GA , Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators. Bioorganic & medicinal chemistry letters. 2013 Sep 15; 23 (18). 5195-8
Wen W , Wu W , Romaine IM , Kaufmann K , Du Y , Sulikowski GA , Weaver CD , Lindsley CW , Discovery of ‘molecular switches’ within a GIRK activator scaffold that afford selective GIRK inhibi… Bioorganic & medicinal chemistry letters. 2013 Aug 15; 23 (16). 4562-6
Kaufmann K , Romaine I , Days E , Pascual C , Malik A , Yang L , Zou B , Du Y , Sliwoski G , Morrison RD , Denton J , Niswender CM , Daniels JS , Sulikowski GA , Xie XS , Lindsley CW , Weaver CD , ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays … ACS chemical neuroscience. 2013 Sep 18; 4 (9). 1278-86
Raphemot R , Weaver CD , Denton JS , High-throughput screening for small-molecule modulators of inward rectifier potassium channels. Journal of visualized experiments : JoVE. 2013 ; (71).
Butkiewicz M , Lowe EW , Mueller R , Mendenhall JL , Teixeira PL , Weaver CD , Meiler J , Benchmarking ligand-based virtual High-Throughput Screening with the PubChem database. Molecules (Basel, Switzerland). 2013 ; 18 (1). 735-56

2012

Rinker C. , Jones L. , Pitts , Rutzler , Camp , Sun , Xu , Dorset C. , Weaver , Zwiebel J. , Novel high-throughput screens of Anopheles gambiae odorant receptors reveal candidate behaviour-modi… Physiological Entomology. 2012 Mar ; 37 (1). 33-41
Ruggiero AM , Wright J , Ferguson SM , Lewis M , Emerson KS , Iwamoto H , Ivy MT , Holmstrand EC , Ennis EA , Weaver CD , Blakely RD , Nonoisotopic assay for the presynaptic choline transporter reveals capacity for allosteric modulatio… ACS chemical neuroscience. 2012 Oct 17; 3 (10). 767-81
Potet F , Lorinc AN , Chaigne S , Hopkins CR , Venkataraman R , Stepanovic SZ , Lewis LM , Days E , Sidorov VY , Engers DW , Zou B , Afshartous D , George AL , Campbell CM , Balser JR , Li M , Baudenbacher FJ , Lindsley CW , Weaver CD , Kupershmidt S , Identification and characterization of a compound that protects cardiac tissue from human Ether-à-g… The Journal of biological chemistry. 2012 Nov 16; 287 (47). 39613-25
Manka JT , Vinson PN , Gregory KJ , Zhou Y , Williams R , Gogi K , Days E , Jadhav S , Herman EJ , Lavreysen H , Mackie C , Bartolomé JM , Macdonald GJ , Steckler T , Daniels JS , Weaver CD , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Stauffer SR , Optimization of an ether series of mGlu5 positive allosteric modulators: molecular determinants of M… Bioorganic & medicinal chemistry letters. 2012 Oct 15; 22 (20). 6481-5
Delpire E , Baranczak A , Waterson AG , Kim K , Kett N , Morrison RD , Daniels JS , Weaver CD , Lindsley CW , Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly select… Bioorganic & medicinal chemistry letters. 2012 Jul 15; 22 (14). 4532-5
Blättermann S , Peters L , Ottersbach PA , Bock A , Konya V , Weaver CD , Gonzalez A , Schröder R , Tyagi R , Luschnig P , Gäb J , Hennen S , Ulven T , Pardo L , Mohr K , Gütschow M , Heinemann A , Kostenis E , A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer. Nature chemical biology. 2012 Jul ; 8 (7). 631-8
Mueller R , Dawson ES , Niswender CM , Butkiewicz M , Hopkins CR , Weaver CD , Lindsley CW , Conn PJ , Meiler J , Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate recep… Journal of molecular modeling. 2012 Sep ; 18 (9). 4437-46
Padula WV , Mishra MK , Weaver CD , Yilmaz T , Splaine ME , Building information for systematic improvement of the prevention of hospital-acquired pressure ulce… BMJ quality & safety. 2012 Jun ; 21 (6). 473-80
Noetzel MJ , Rook JM , Vinson PN , Cho HP , Days E , Zhou Y , Rodriguez AL , Lavreysen H , Stauffer SR , Niswender CM , Xiang Z , Daniels JS , Jones CK , Lindsley CW , Weaver CD , Conn PJ , Functional impact of allosteric agonist activity of selective positive allosteric modulators of meta… Molecular pharmacology. 2012 Feb ; 81 (2). 120-33
Noetzel MJ , Rook JM , Vinson PN , Cho HP , Days E , Zhou Y , Rodriguez AL , Lavreysen H , Stauffer SR , Niswender CM , Xiang Z , Daniels JS , Jones CK , Lindsley CW , Weaver CD , Conn PJ , Functional impact of allosteric agonist activity of selective positive allosteric modulators of meta… Molecular pharmacology. 2012 Feb ; 81 (2). 120-33
Rodriguez AL , Zhou Y , Williams R , Weaver CD , Vinson PN , Dawson ES , Steckler T , Lavreysen H , Mackie C , Bartolomé JM , Macdonald GJ , Daniels JS , Niswender CM , Jones CK , Conn PJ , Lindsley CW , Stauffer SR , Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonami… Bioorganic & medicinal chemistry letters. 2012 Dec 15; 22 (24). 7388-92

2011

Thorne CA , Lafleur B , Lewis M , Hanson AJ , Jernigan KK , Weaver DC , Huppert KA , Chen TW , Wichaidit C , Cselenyi CS , Tahinci E , Meyers KC , Waskow E , Orton D , Salic A , Lee LA , Robbins DJ , Huppert SS , Lee E , A biochemical screen for identification of small-molecule regulators of the Wnt pathway using Xenopu… Journal of biomolecular screening. 2011 Oct ; 16 (9). 995-1006
Stoops SL , Pearson AS , Weaver C , Waterson AG , Days E , Farmer C , Brady S , Weaver CD , Beauchamp RD , Lindsley CW , Identification and optimization of small molecules that restore E-cadherin expression and reduce inv… ACS chemical biology. 2011 May 20; 6 (5). 452-65
Reid PR , Bridges TM , Sheffler DJ , Cho HP , Lewis LM , Days E , Daniels JS , Jones CK , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , Wood MR , Discovery and optimization of a novel, selective and brain penetrant M1 positive allosteric modulato… Bioorganic & medicinal chemistry letters. 2011 May 1; 21 (9). 2697-701
Bhave G , Chauder BA , Liu W , Dawson ES , Kadakia R , Nguyen TT , Lewis LM , Meiler J , Weaver CD , Satlin LM , Lindsley CW , Denton JS , Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium c… Molecular pharmacology. 2011 Jan ; 79 (1). 42-50
Xiang Z , Thompson AD , Brogan JT , Schulte ML , Melancon BJ , Mi D , Lewis LM , Zou B , Yang L , Morrison R , Santomango T , Byers F , Brewer K , Aldrich JS , Yu H , Dawson ES , Li M , McManus O , Jones CK , Daniels JS , Hopkins CR , Xie XS , Conn PJ , Weaver CD , Lindsley CW , The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibi… ACS chemical neuroscience. 2011 Dec 21; 2 (12). 730-742
Raphemot R , Lonergan DF , Nguyen TT , Utley T , Lewis LM , Kadakia R , Weaver CD , Gogliotti R , Hopkins C , Lindsley CW , Denton JS , Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifie… Frontiers in pharmacology. 2011 ; 2 75
Williams R , Manka JT , Rodriguez AL , Vinson PN , Niswender CM , Weaver CD , Jones CK , Conn PJ , Synthesis and SAR of centrally active mGlu5 positive allosteric modulators based on an aryl acetylen… Bioorganic & medicinal chemistry letters. 2011 Mar 1; 21 (5). 1350-3
Xiang Z , Thompson AD , Brogan JT , Schulte ML , Melancon BJ , Mi D , Lewis LM , Zou B , Yang L , Morrison R , Santomango T , Byers F , Brewer K , Aldrich JS , Yu H , Dawson ES , Li M , McManus O , Jones CK , Daniels JS , Hopkins CR , Xie XS , Conn PJ , Weaver CD , Lindsley CW , The Discovery and Characterization of ML218: A Novel, Centrally Active T-Type Calcium Channel Inhibi… ACS chemical neuroscience. 2011 Dec 21; 2 (12). 730-742
Jones CK , Engers DW , Thompson AD , Field JR , Blobaum AL , Lindsley SR , Zhou Y , Gogliotti RD , Jadhav S , Zamorano R , Bogenpohl J , Smith Y , Morrison R , Daniels JS , Weaver CD , Conn PJ , Lindsley CW , Niswender CM , Hopkins CR , Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxop… Journal of medicinal chemistry. 2011 Nov 10; 54 (21). 7639-47
Weaver CD , Triple-addition assay protocols for detecting and characterizing modulators of seven-transmembrane r… Current protocols in chemical biology. 2011 Sep 1; 3 (3). 119-40
Miller M , Shi J , Zhu Y , Kustov M , Tian JB , Stevens A , Wu M , Xu J , Long S , Yang P , Zholos AV , Salovich JM , Weaver CD , Hopkins CR , Lindsley CW , McManus O , Li M , Zhu MX , Identification of ML204, a novel potent antagonist that selectively modulates native TRPC4/C5 ion ch… The Journal of biological chemistry. 2011 Sep 23; 286 (38). 33436-46
Manna JD , Reyzer ML , Latham JC , Weaver CD , Marnett LJ , Caprioli RM , High-throughput quantification of bioactive lipids by MALDI mass spectrometry: application to prosta… Analytical chemistry. 2011 Sep 1; 83 (17). 6683-8
Cheung YY , Zamorano R , Blobaum AL , Weaver CD , Conn PJ , Lindsley CW , Niswender CM , Hopkins CR , Solution-phase parallel synthesis and SAR of homopiperazinyl analogs as positive allosteric modulato… ACS combinatorial science. 2011 Mar 14; 13 (2). 159-65
Pantel J , Williams SY , Mi D , Sebag J , Corbin JD , Weaver CD , Cone RD , Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signali… European journal of pharmacology. 2011 Jun 11; 660 (1). 139-47
Engers DW , Field JR , Le U , Zhou Y , Bolinger JD , Zamorano R , Blobaum AL , Jones CK , Jadhav S , Weaver CD , Conn PJ , Lindsley CW , Niswender CM , Hopkins CR , Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)… Journal of medicinal chemistry. 2011 Feb 24; 54 (4). 1106-10

2010

Zhou Y , Manka JT , Rodriguez AL , Weaver CD , Days EL , Vinson PN , Jadhav S , Hermann EJ , Jones CK , Conn PJ , Lindsley CW , Stauffer SR , Discovery of N-Aryl Piperazines as Selective mGlu(5) Potentiators with Efficacy in a Rodent Model Pr… ACS medicinal chemistry letters. 2010 Nov 11; 1 (8). 433-438
Rodriguez AL , Grier MD , Jones CK , Herman EJ , Kane AS , Smith RL , Williams R , Zhou Y , Marlo JE , Days EL , Blatt TN , Jadhav S , Menon UN , Vinson PN , Rook JM , Stauffer SR , Niswender CM , Lindsley CW , Weaver CD , Conn PJ , Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemic… Molecular pharmacology. 2010 Dec ; 78 (6). 1105-23
Lewis M , Weaver CD , McClain MS , Identification of Small Molecule Inhibitors of Clostridium perfringens ε-Toxin Cytotoxicity Using a… Toxins. 2010 Jul 1; 2 (7). 1825-1847
Engers DW , Gentry PR , Williams R , Bolinger JD , Weaver CD , Menon UN , Conn PJ , Lindsley CW , Niswender CM , Hopkins CR , Synthesis and SAR of novel, 4-(phenylsulfamoyl)phenylacetamide mGlu4 positive allosteric modulators … Bioorganic & medicinal chemistry letters. 2010 Sep 1; 20 (17). 5175-8
Mueller R , Rodriguez AL , Dawson ES , Butkiewicz M , Nguyen TT , Oleszkiewicz S , Bleckmann A , Weaver CD , Lindsley CW , Conn PJ , Meiler J , Identification of Metabotropic Glutamate Receptor Subtype 5 Potentiators Using Virtual High-Throughp… ACS chemical neuroscience. 2010 Apr 21; 1 (4). 288-305
Lebois EP , Bridges TM , Lewis LM , Dawson ES , Kane AS , Xiang Z , Jadhav SB , Yin H , Kennedy JP , Meiler J , Niswender CM , Jones CK , Conn PJ , Weaver CD , Lindsley CW , Discovery and characterization of novel subtype-selective allosteric agonists for the investigation … ACS chemical neuroscience. 2010 ; 1 (2). 104-121
Niswender CM , Johnson KA , Miller NR , Ayala JE , Luo Q , Williams R , Saleh S , Orton D , Weaver CD , Conn PJ , Context-dependent pharmacology exhibited by negative allosteric modulators of metabotropic glutamate… Molecular pharmacology. 2010 Mar ; 77 (3). 459-68

2009

Delpire E , Days E , Lewis LM , Mi D , Kim K , Lindsley CW , Weaver CD , Small-molecule screen identifies inhibitors of the neuronal K-Cl cotransporter KCC2. Proceedings of the National Academy of Sciences of the United States of America. 2009 Mar 31; 106 (13). 5383-8
Aldrich LN , Lebois EP , Lewis LM , Nalywajko NT , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , MAOS ls for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]p… Tetrahedron letters. 2009 Jan 14; 50 (2). 212-215
Marlo JE , Niswender CM , Days EL , Bridges TM , Xiang Y , Rodriguez AL , Shirey JK , Brady AE , Nalywajko T , Luo Q , Austin CA , Williams MB , Kim K , Williams R , Orton D , Brown HA , Lindsley CW , Weaver CD , Conn PJ , Discovery and characterization of novel allosteric potentiators of M1 muscarinic receptors reveals m… Molecular pharmacology. 2009 Mar ; 75 (3). 577-88
Zhou Y , Rodriguez AL , Williams R , Weaver CD , Conn PJ , Lindsley CW , Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. Bioorganic & medicinal chemistry letters. 2009 Dec 1; 19 (23). 6502-6
Felts AS , Saleh SA , Le U , Rodriguez AL , Weaver CD , Conn PJ , Lindsley CW , Emmitte KA , Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5. Bioorganic & medicinal chemistry letters. 2009 Dec 1; 19 (23). 6623-6
Weaver CD , Sheffler DJ , Lewis LM , Bridges TM , Williams R , Nalywajko NT , Kennedy JP , Mulder MM , Jadhav S , Aldrich LA , Jones CK , Marlo JE , Niswender CM , Mock MM , Zheng F , Conn PJ , Lindsley CW , Discovery and development of a potent and highly selective small molecule muscarinic acetylcholine r… Current topics in medicinal chemistry. 2009 ; 9 (13). 1217-26
Lewis LM , Bhave G , Chauder BA , Banerjee S , Lornsen KA , Redha R , Fallen K , Lindsley CW , Weaver CD , Denton JS , High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium … Molecular pharmacology. 2009 Nov ; 76 (5). 1094-103
Williams R , Johnson KA , Gentry PR , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , Hopkins CR , Synthesis and SAR of a novel positive allosteric modulator (PAM) of the metabotropic glutamate recep… Bioorganic & medicinal chemistry letters. 2009 Sep 1; 19 (17). 4967-70
Engers DW , Niswender CM , Weaver CD , Jadhav S , Menon UN , Zamorano R , Conn PJ , Lindsley CW , Hopkins CR , Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic… Journal of medicinal chemistry. 2009 Jul 23; 52 (14). 4115-8
Rodriguez AL , Williams R , Zhou Y , Lindsley SR , Le U , Grier MD , Weaver CD , Conn PJ , Lindsley CW , Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype. Bioorganic & medicinal chemistry letters. 2009 Jun 15; 19 (12). 3209-13
Bridges TM , Marlo JE , Niswender CM , Jones CK , Jadhav SB , Gentry PR , Plumley HC , Weaver CD , Conn PJ , Lindsley CW , Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive… Journal of medicinal chemistry. 2009 Jun 11; 52 (11). 3445-8
Yilmaz T , Weaver CD , Gallagher MJ , Cordero-Coma M , Cervantes-Castaneda RA , Klisovic D , Lavaque AJ , Larson RJ , Intravitreal triamcinolone acetonide injection for treatment of refractory diabetic macular edema: a… Ophthalmology. 2009 May ; 116 (5). 902-11; quiz 912-3
Sheffler DJ , Williams R , Bridges TM , Xiang Z , Kane AS , Byun NE , Jadhav S , Mock MM , Zheng F , Lewis LM , Jones CK , Niswender CM , Weaver CD , Lindsley CW , Conn PJ , A novel selective muscarinic acetylcholine receptor subtype 1 antagonist reduces seizures without im… Molecular pharmacology. 2009 Aug ; 76 (2). 356-68

2008

Gentles RG , Hu S , Huang Y , Grant-Young K , Poss MA , Andres C , Fiedler T , Knox R , Lodge N , Weaver CD , Harden DG , Preliminary SAR studies on non-apamin-displacing 4-(aminomethylaryl)pyrrazolopyrimidine K(Ca) channe… Bioorganic & medicinal chemistry letters. 2008 Oct 15; 18 (20). 5694-7
Gentles RG , Grant-Young K , Hu S , Huang Y , Poss MA , Andres C , Fiedler T , Knox R , Lodge N , Weaver CD , Harden DG , Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conduct… Bioorganic & medicinal chemistry letters. 2008 Oct 1; 18 (19). 5316-9
Niswender CM , Johnson KA , Weaver CD , Jones CK , Xiang Z , Luo Q , Rodriguez AL , Marlo JE , de Paulis T , Thompson AD , Days EL , Nalywajko T , Austin CA , Williams MB , Ayala JE , Williams R , Lindsley CW , Conn PJ , Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of … Molecular pharmacology. 2008 Nov ; 74 (5). 1345-58
Lewis LM , Sheffler D , Williams R , Bridges TM , Kennedy JP , Brogan JT , Mulder MJ , Williams L , Nalywajko NT , Niswender CM , Weaver CD , Conn PJ , Lindsley CW , Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists. Bioorganic & medicinal chemistry letters. 2008 Feb 1; 18 (3). 885-90
Niswender CM , Johnson KA , Luo Q , Ayala JE , Kim C , Conn PJ , Weaver CD , A novel assay of Gi/o-linked G protein-coupled receptor coupling to potassium channels provides new … Molecular pharmacology. 2008 Apr ; 73 (4). 1213-24

2004

Faria TN , Timoszyk JK , Stouch TR , Vig BS , Landowski CP , Amidon GL , Weaver CD , Wall DA , Smith RL , A novel high-throughput pepT1 transporter assay differentiates between substrates and antagonists. Molecular pharmaceutics. 2004 Jan 12; 1 (1). 67-76
Weaver CD , Harden D , Dworetzky SI , Robertson B , Knox RJ , A thallium-sensitive, fluorescence-based assay for detecting and characterizing potassium channel mo… Journal of biomolecular screening. 2004 Dec ; 9 (8). 671-7

Trads JB , Burgstaller J , Laprell L , Konrad DB , de la Osa de la Rosa L , Weaver CD , Baier H , Trauner D , Barber DM , Optical control of GIRK channels using visible light Organic & biomolecular chemistry. ; 15 (1). 76-81
Weaver CD , Thallium Flux Assay for Measuring the Activity of Monovalent Cation Channels and Transporters Methods in molecular biology (Clifton, N.J.). ; 1684 105-114