Discovery and SAR of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of mGlu5.
AUTHORS
Felts
ASAndrew S ,
Saleh
SA Sam A ,
Le
U Uyen ,
Rodriguez
AL Alice L ,
Weaver
CD C David ,
Conn
PJ P Jeffrey ,
Lindsley
CW Craig W ,
Emmitte
KA Kyle A .
Bioorganic & medicinal chemistry letters. 2009 12 1; 19(23).
6623-6
- PMID: 19854049[PubMed].
- PMCID: PMC2801349.
- NIHMSID: NIHMS159411
ABSTRACT
A high-throughput cell-based screen identified a series of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of metabotropic glutamate receptor 5 (mGlu(5)). This Letter describes the SAR of this series and the profile of selected compounds in selectivity and radioligand binding assays.
A high-throughput cell-based screen identified a series of 6-substituted-4-anilinoquinazolines as non-competitive antagonists of metabotropic glutamate receptor 5 (mGlu(5)). This Letter describes the SAR of this series and the profile of selected compounds in selectivity and radioligand binding assays.