Discovery and SAR of a novel series of non-MPEP site mGlu₅ PAMs based on an aryl glycine sulfonamide scaffold.
AUTHORS
Rodriguez
ALAlice L ,
Zhou
Y Ya ,
Williams
R Richard ,
Weaver
CD C David ,
Vinson
PN Paige N ,
Dawson
ES Eric S ,
Steckler
T Thomas ,
Lavreysen
H Hilde ,
Mackie
C Claire ,
Bartolomé
JM José M ,
Macdonald
GJ Gregor J ,
Daniels
JS J Scott ,
Niswender
CM Colleen M ,
Jones
CK Carrie K ,
Conn
PJ P Jeffrey ,
Lindsley
CW Craig W ,
Stauffer
SR Shaun R .
Bioorganic & medicinal chemistry letters. 2012 12 15; 22(24).
7388-92
- PMID: 23142615[PubMed].
- PMCID: PMC3539767.
- NIHMSID: NIHMS421242
ABSTRACT
Herein we report the discovery and SAR of a novel series of non-MPEP site metabotropic glutamate receptor 5 (mGlu(5)) positive allosteric modulators (PAMs) based on an aryl glycine sulfonamide scaffold. This series represents a rare non-MPEP site mGlu(5) PAM chemotype.
Herein we report the discovery and SAR of a novel series of non-MPEP site metabotropic glutamate receptor 5 (mGlu(5)) positive allosteric modulators (PAMs) based on an aryl glycine sulfonamide scaffold. This series represents a rare non-MPEP site mGlu(5) PAM chemotype.