SARS-CoV-2 shares a similar character with influenza. Check out our collaborative work on Nsp1 published in Science Advances!
Feb. 5, 2021
Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression
https://advances.sciencemag.org/content/7/6/eabe7386
Congratulations Mei for his findings published in PNAS! A wonderful collaborative work on elucidating how SARS-CoV-2 hijacks Nup98 to antagonize interferon signaling!
Oct. 24, 2020
We previously revealed the mechanism of how vesicular stomatitis virus hijacks Nup98 to block host gene expression. Our most recent work published in PNAS shows that SARS-CoV-2 utilizes a similar strategy to target Nup98 in order to block interferon signaling.
Our review “Mechanisms of nuclear mRNA export: a structural perspective” is online now!
Sep. 12, 2019
It is published in the virtual issue “Membrane Traffic at Atomic Resolution” of Traffic, edited by Dr. Lauren Jackson.
Yi presented at the Nuclear Transport 2019 meeting in Scotland.
Aug. 27, 2019
Thanks to Eric Schirmer and Mark Field for organizing such a wonderful meeting!
Our NIH MIRA grant is funded!
Aug. 16, 2019
Our MIRA grant entitled “Mechanisms and Regulation of Nuclear mRNA Export” is officially funded!
Ren lab’s first paper online in Nature Microbiology
Jul. 1, 2019
Our first research paper “Structural basis for influenza virus NS1 protein block of mRNA nuclear export” has just been published online in Nature Microbiology.
