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SARS-CoV-2 shares a similar character with influenza. Check out our collaborative work on Nsp1 published in Science Advances!

Feb. 5, 2021

Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression

https://advances.sciencemag.org/content/7/6/eabe7386

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Our cryo-EM structure of the mRNP remodeling machinery posted at bioRxiv!

Jan. 4, 2021

Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2

Yihu XieBradley P ClarkeYong Joon KimAustin L IveyPate S HillYi ShiYi Ren

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Congratulations Mei for his findings published in PNAS! A wonderful collaborative work on elucidating how SARS-CoV-2 hijacks Nup98 to antagonize interferon signaling!

Oct. 24, 2020

We previously revealed the mechanism of how vesicular stomatitis virus hijacks Nup98 to block host gene expression. Our most recent work published in PNAS shows that SARS-CoV-2 utilizes a similar strategy to target Nup98 in order to block interferon signaling.

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Farewell lunch for Austin!

Jan. 17, 2020

Farewell lunch for Austin. We wish him all the best!

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