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The focus of the Schey lab is on the development and application of mass spectrometry to understand fundamental biochemical processes in health and disease. Areas of technology development include: imaging mass spectrometry, membrane protein analysis, and proteomics. Areas of application include: protein aging, ocular lens biochemistry and retina diseases such as age-related macular degeneration. State-of-the-art instrumentation and methods, such as hydrogen-deuterium exchange MS, imaging mass spectrometry, native mass spectrometry, top-down mass spectrometry, and single cell proteomics, are employed to examine protein-protein interactions, post-translational modifications, protein crosslinking, spatially-resolved proteomics/lipidomics, and cell aging.