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The triple negative breast cancer line, MDA-MD-231, exhibit high levels of beta-catenin staining (left) and elevated Wnt signaling. Incubating MDA-MD-231 cells with an antibody that binds the Wnt coreceptor, LRP6, dramatically decreases cytoplasmic beta-catenin staining and promotes beta-catenin localization to the cell junctions (right). Green is beta-catenin and blue is DNA.

Posted by on Tuesday, June 12, 2018 in Uncategorized.