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Kathryn McCulloch, Ph.D.

Assistant Professor, Chemistry and Biochemistry, California Polytechnic University, Pomona


Ph.D. Cornell University, Chemistry and Chemical Biology, 2010
M.S. Cornell University, Chemistry and Chemical Biology, 2006
B.S. Ball State University, Chemistry, 2004


McCulloch, K.M., McCranie, E.K., Smith, J.A., Sarwar, M., Mathieu, J.L., Gitschlag, B.L., Du, Y., Bachmann, B.O., Iverson, T.M. Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. (2015) Proc Natl Acad Sci USA. PMID: 26240321

McCulloch, K.M., Mukherjee, T., Begley, T.P., and Ealick, S.E. (2010) Structure Determination and Characterization of the Vitamin B6 Degradative Enzyme 2-(Acetamidomethylene)succinate Hydrolase.  Biochemistry. 49(6): 1226-1235.

Mukherjee, T., McCulloch, K.M., Ealick, S.E., and Begley, T.P. (2010) Cofactor Catabolism – An Underexplored Frontier, in Cofactor Metabolism, in Comprehensive Natural Products Chemistry II (Mander, L. and Liu, H-W., Ed.) Elsevier Science, Oxford. Vol 7: 649-674.

McCulloch, K.M., Mukherjee, T., Begley, T.P., and Ealick, S.E. (2009) Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic Acid Oxygenase from Mesorhizobium loti MAFF303099 and Its Mechanistic Implications.  Biochemistry. 48(19): 4139-4149.

McCulloch, K.M., Kinsland, C., Begley, T.P., and Ealick, S.E. (2008) Structural Studies of Thiamin Monophosphate Kinase in Complex with Substrates and Products.  Biochem. 47, 3810-3821.

Mukherjee, T.*, McCulloch, K.M.*, Ealick, S.E., and Begley, T.P. (2007) Gene Identification and Structural Characterization of the Pyridoxal 5′-Phosphate Degradative Protein 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate Decarboxylase from Mesorhizobium loti MAFF303099.  Biochem. 46, 13606-13615. * these authors contributed equally to this work.

Owegi, M.A., Pappas, D.L., Finch, M.W., Bilbo, S.A., Resendiz, C.A., Jacquemin, L.J., Warrier, A., Trombley, J.D., McCulloch, K.M., Margalef, K.L.M., Mertz, M.J., Storms, J.M., Damin, C.A., and Parra, K.J. (2006) Identification of a Domain in the Vo Subunit d that is Critical for Coupling of the Yeast Vacuolar Proton-translocating ATPase.  J. Biol. Chem. 281, 30001-30014.

Parra-Belky, K., McCulloch, K.M., Wick, N., Shircliff, R., Croft, N., Margalef, K., Brown, J., Crabill, T., Jankord, R., and Waldo, E. (2005) Immunoprecipitation and Characterization of Membrane Protein Complexes from Yeast.  Biochem. and Mol. Biol. Ed. 33, 289-292.