Skip to main content

Iverson Lab Publications

2021

Chen Q. , Zhuo Y. , Sharma P. , Perez I. , Francis D. J. , Chakravarthy S. , Vishnivetskiy S. A. , Berndt S. , Hanson S. M. , Zhan X. , Brooks E. K. , Altenbach C. , Hubbell W. L. , Klug C. S. , Iverson T. M. , Gurevich V. V. , An Eight Amino Acid Segment Controls Oligomerization and Preferred Conformation of the two Non-visual Arrestins Journal of Molecular Biology. 2021 Feb 19; 433 (4).

2020

Stubbs HE , Bensing BA , Yamakawa I , Sharma P , Yu H , Chen X , Sullam PM , Iverson TM , Tandem sialoglycan-binding modules in a Streptococcus sanguinis serine-rich repeat adhesin create target dependent avidity effects Journal of Biological Chemistry. 2020 Aug 20;
Sharma P , Maklashina E , Cecchini G , Iverson T M , The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein Proceedings of the National Academy of Sciences of the United States of America. 2020 Sep 4;
kaya AI , Perry NA , Gurevich VV , Iverson TM , Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor Proceedings of the National Academy of Sciences of the United States of America. 2020 Jun 23;

2019

Sammons RM , Perry NA , Li Y , Cho EJ , Piserchio A , Zamora-Olivares DP , Ghose R , Kaoud TS , Debevec G , Bartholomeusz C , Gurevich VV , Iverson TM , Giulianotti M , Houghten RA , Dalby KN , A novel class of common docking domain inhibitors that prevent ERK2 activation and substrate phosphorylation ACS Chemical Biology. 2019 Jun 21;
Perry NA , Fialkowski KP , Kaoud TS , Kaya AI , Chen AL , Taliaferro JM , Gurevich VV , Dalby KN , Iverson TM , Arrestin-3 interaction with maternal embryonic leucine-zipper kinase Cellular Signalling . 2019 Nov ;
Berndt S , Gurevich VV , Iverson TM , Crystal structure of the SH3 domain of human Lyn non-receptor tyrosine kinase PLoS One. 2019 Apr 10;
Perry NA , Kaoud TS , Ortega OO , Kaya AI , Marcus DJ , Pleinis JM , Berndt S , Chen Q , Zhan X , Dalby KN , Lopez CF , Iverson TM , Gurevich VV , Arrestin-3 scaffolding of the JNK3 cascade suggests a mechanism for signal amplification Proceedings of the National Academy of Sciences of the United States of America. 2019 Jan 15;
Sharma P , Maklashina E , Cecchini G , Iverson TM , Maturation of the respiratory complex II flavoprotein Current opinion in structural biology. 2019 Mar 6; 59 38-46
Perry NA , Zhan X , Gurevich EV , Iverson TM , Gurevich VV , Using In Vitro Pull-Down and In-Cell Overexpression Assays to Study Protein Interactions with Arrestin Methods in molecular biology (Clifton, N.J.). 2019 Mar ; 1957 107-120
McCulloch KM , Yamakawa I , Shifrin DA , McConnell RE , Foegeding NJ , Singh PK , Mao S , Tyska MJ , Iverson TM , An alternative N-terminal fold of the intestine-specific annexin A13a induces dimerization and regulates membrane-binding The Journal of biological chemistry. 2019 Jan 4;

2018

Badmalia MD , Sharma P , Yadav SPS , Singh S , Khatri N , Garg R , Ashish FNU , Bonsai Gelsolin Survives Heat Induced Denaturation by Forming β-Amyloids which Leach Out Functional Monomer Scientific Reports. 2018 ; 8
Sharma P , Maklashina E , Cecchini G , Iverson TM , Crystal structure of an assembly intermediate of respiratory Complex II. Nature communications. 2018 Jan 18; 9 (1). 274
Starbird CA , Perry NA , Chen Q , Berndt S , Yamakawa I , Loukachevitch LV , Limbrick EM , Bachmann BO , Iverson TM , McCulloch KM , The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains Biochemistry. 2018 Dec 7;
Chen Q , Iverson TM , Gurevich VV , Structural Basis of Arrestin-Dependent Signal Transduction. Trends in biochemical sciences. 2018 Apr 7; 6 (43). 412-23
Maklashina E , Rajagukguk S , Iverson TM , Cecchini G , The unassembled flavoprotein subunits of human and bacterial complex II have impaired catalytic activity and generate only minor amounts of ROS. The Journal of biological chemistry. 2018 Apr 2; 20 (293). 7754-65
Starbird CA , Tomasiak TM , Singh PK , Yankovskaya V , Maklashina E , Eisenbach M , Cecchini G , Iverson TM , New crystal forms of the integral membrane Escherichia coli quinol:fumarate reductase suggest that ligands control domain movement. Journal of structural biology. 2018 Apr ; 202 (1). 100-104
Tso SC , Chen Q , Vishnivetskiy SA , Gurevich VV , Iverson TM , Brautigam CA , Using two-site binding models to analyze microscale thermophoresis data. Analytical biochemistry. 2018 Jan 1; 540-541 64-75

2017

Chen Q , Perry NA , Vishnivetskiy SA , Berndt S , Gilbert NC , Zhuo Y , Singh PK , Tholen J , Ohi MD , Gurevich EV , Brautigam CA , Klug CS , Gurevich VV , Iverson TM , Structural basis of arrestin-3 activation and signaling. Nature communications. 2017 Nov 10; 8 (1). 1427
Starbird CA , Maklashina E , Sharma P , Qualls-Histed S , Cecchini G , Iverson TM , Structural and biochemical analyses reveal insights into covalent flavinylation of the Complex II homolog quinol:fumarate reductase. The Journal of biological chemistry. 2017 Dec 4; 292 (31). 12921-12933
Prokop S , Perry NA , Vishnivetskiy SA , Toth AD , Inoue A , Milligan G , Iverson TM , Hunyady L , Gurevich VV , Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors. Cellular signalling. 2017 Aug ; 36 98-107

2016

Loukachevitch LV , Bensing BA , Yu H , Zeng J , Chen X , Sullam PM , Iverson TM , Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand. Biochemistry. 2016 Oct 11;
Kaya AI , Lokits AD , Gilbert JA , Iverson TM , Meiler J , Hamm HE , A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor. The Journal of biological chemistry. 2016 Dec 9; 291 (37). 19674-86
Bensing BA , Khedri Z , Deng L , Yu H , Prakobphol A , Fisher SJ , Chen X , Iverson TM , Varki A , Sullam PM , Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins. Glycobiology. 2016 Dec ; 26 (11). 1222-1234
Zhan X , Stoy H , Kaoud TS , Perry NA , Chen Q , Perez A , Els-Heindl S , Slagis JV , Iverson TM , Beck-Sickinger AG , Gurevich EV , Dalby KN , Gurevich VV , Peptide mini-scaffold facilitates JNK3 activation in cells. Scientific reports. 2016 Feb 12; 6 21025
Maklashina E , Rajagukguk S , Starbird CA , McDonald WH , Koganitsky A , Eisenbach M , Iverson TM , Cecchini G , Binding of the Covalent Flavin Assembly Factor to the Flavoprotein Subunit of Complex II. The Journal of biological chemistry. 2016 Feb 5; 291 (6). 2904-16
Bensing BA , Loukachevitch LV , McCulloch KM , Yu H , Vann KR , Wawrzak Z , Anderson S , Chen X , Sullam PM , Iverson TM , Structural Basis for Sialoglycan Binding by the Streptococcus sanguinis SrpA Adhesin. The Journal of biological chemistry. 2016 Apr 1; 291 (14). 7230-40

2015

McCulloch KM , McCranie EK , Smith JA , Sarwar M , Mathieu JL , Gitschlag BL , Du Y , Bachmann BO , Iverson TM , Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 2015 Aug 3;
Chen Q , Vishnivetskiy SA , Zhuang T , Cho MK , Thaker TM , Sanders CR , Gurevich VV , Iverson TM , The rhodopsin-arrestin-1 interaction in bicelles. Methods in molecular biology (Clifton, N.J.). 2015 ; 1271 77-95
Kaya AI , Iverson TM , Hamm HE , Functional stability of rhodopsin in a bicelle system: evaluating G protein activation by rhodopsin in bicelles. Methods in molecular biology (Clifton, N.J.). 2015 ; 1271 67-76

2014

Vishnivetskiy SA , Zhan X , Chen Q , Iverson TM , Gurevich VV , Arrestin expression in E. coli and purification. Current protocols in pharmacology. 2014 Dec 1; 67 Unit 2.11.1-19
Kaya AI , Lokits AD , Gilbert JA , Iverson TM , Meiler J , Hamm HE , A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit. The Journal of biological chemistry. 2014 Aug 29; 289 (35). 24475-87
Birmingham WR , Starbird CA , Panosian TD , Nannemann DP , Iverson TM , Bachmann BO , Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nature chemical biology. 2014 May ; 10 (5). 392-9
Thaker TM , Sarwar M , Preininger AM , Hamm HE , Iverson TM , A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1. The Journal of biological chemistry. 2014 Apr 18; 289 (16). 11331-41

2013

Seo HS , Minasov G , Seepersaud R , Doran KS , Dubrovska I , Shuvalova L , Anderson WF , Iverson TM , Sullam PM , Characterization of fibrinogen binding by glycoproteins Srr1 and Srr2 of Streptococcus agalactiae. The Journal of biological chemistry. 2013 Dec 13; 288 (50). 35982-96
Singh PK , Sarwar M , Maklashina E , Kotlyar V , Rajagukguk S , Tomasiak TM , Cecchini G , Iverson TM , Plasticity of the quinone-binding site of the complex II homolog quinol:fumarate reductase. The Journal of biological chemistry. 2013 Aug 23; 288 (34). 24293-301
Iverson TM , Sexism: A revealing experiment. Nature. 2013 Apr 4; 496 (7443). 31
Zhuang T , Chen Q , Cho MK , Vishnivetskiy SA , Iverson TM , Gurevich VV , Sanders CR , Involvement of distinct arrestin-1 elements in binding to different functional forms of rhodopsin. Proceedings of the National Academy of Sciences of the United States of America. 2013 Jan 15; 110 (3). 942-7
Vishnivetskiy SA , Chen Q , Palazzo MC , Brooks EK , Altenbach C , Iverson TM , Hubbell WL , Gurevich VV , Engineering visual arrestin-1 with special functional characteristics. The Journal of biological chemistry. 2013 Feb 1; 288 (5). 3394-405
Thaker TM , Tanabe M , Fowler ML , Preininger AM , Ingram-Smith C , Smith KS , Iverson TM , Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans. Journal of structural biology. 2013 Feb ; 181 (2). 185-9
Iverson TM , Catalytic mechanisms of complex II enzymes: a structural perspective. Biochimica et biophysica acta. 2013 May ; 1827 (5). 648-57

2012

Iverson TM , Maklashina E , Cecchini G , Structural basis for malfunction in complex II. The Journal of biological chemistry. 2012 Oct 12; 287 (42). 35430-8
Iverson TM , Panosian TD , Birmingham WR , Nannemann DP , Bachmann BO , Molecular differences between a mutase and a phosphatase: investigations of the activation step in Bacillus cereus phosphopentomutase. Biochemistry. 2012 Mar 6; 51 (9). 1964-75
Lee JY , Duan L , Iverson TM , Dima RI , Exploring the role of topological frustration in actin refolding with molecular simulations. The journal of physical chemistry. B. 2012 Feb 9; 116 (5). 1677-86
Thaker TM , Kaya AI , Preininger AM , Hamm HE , Iverson TM , Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective. Methods in molecular biology (Clifton, N.J.). 2012 ; 796 133-74

2011

Panosian TD , Nannemann DP , Watkins GR , Phelan VV , McDonald WH , Wadzinski BE , Bachmann BO , Iverson TM , Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. The Journal of biological chemistry. 2011 Mar 11; 286 (10). 8043-54
Lee JY , Iverson TM , Dima RI , Molecular investigations into the mechanics of actin in different nucleotide states. The journal of physical chemistry. B. 2011 Jan 13; 115 (1). 186-95
Tomasiak TM , Archuleta TL , Andréll J , Luna-Chávez C , Davis TA , Sarwar M , Ham AJ , McDonald WH , Yankovskaya V , Stern HA , Johnston JN , Maklashina E , Cecchini G , Iverson TM , Geometric restraint drives on- and off-pathway catalysis by the Escherichia coli menaquinol:fumarate reductase. The Journal of biological chemistry. 2011 Jan 28; 286 (4). 3047-56
Pyburn TM , Bensing BA , Xiong YQ , Melancon BJ , Tomasiak TM , Ward NJ , Yankovskaya V , Oliver KM , Cecchini G , Sulikowski GA , Tyska MJ , Sullam PM , Iverson TM , A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors. PLoS pathogens. 2011 Jul ; 7 (7). e1002112
Kuchtey J , Olson LM , Rinkoski T , Mackay EO , Iverson TM , Gelatt KN , Haines JL , Kuchtey RW , Mapping of the disease locus and identification of ADAMTS10 as a candidate gene in a canine model of primary open angle glaucoma. PLoS genetics. 2011 Feb ; 7 (2). e1001306
Kaya AI , Thaker TM , Preininger AM , Iverson TM , Hamm HE , Coupling efficiency of rhodopsin and transducin in bicelles. Biochemistry. 2011 Apr 19; 50 (15). 3193-203

2010

Tanabe M , Nimigean CM , Iverson TM , Structural basis for solute transport, nucleotide regulation, and immunological recognition of Neisseria meningitidis PorB. Proceedings of the National Academy of Sciences of the United States of America. 2010 Apr 13; 107 (15). 6811-6
Pyburn TM , Yankovskaya V , Bensing BA , Cecchini G , Sullam PM , Iverson TM , Purification, crystallization and preliminary X-ray diffraction analysis of the carbohydrate-binding region of the Streptococcus gordonii adhesin GspB. Acta crystallographica. Section F, Structural biology and crystallization communications. 2010 Nov 1; 66 (Pt 11). 1503-7
Vey JL , Al-Mestarihi A , Hu Y , Funk MA , Bachmann BO , Iverson TM , Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis . Biochemistry. 2010 Nov 2; 49 (43). 9306-17
Panosian TD , Nannemann DP , Bachmann BO , Iverson TM , Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus. Acta crystallographica. Section F, Structural biology and crystallization communications. 2010 Jul 1; 66 (Pt 7). 811-4

2009

Thompson AN , Kim I , Panosian TD , Iverson TM , Allen TW , Nimigean CM , Mechanism of potassium-channel selectivity revealed by Na(+) and Li(+) binding sites within the KcsA pore. Nature structural & molecular biology. 2009 Dec ; 16 (12). 1317-24
Tanabe M , Iverson TM , Expression, purification and preliminary X-ray analysis of the Neisseria meningitidis outer membrane protein PorB. Acta crystallographica. Section F, Structural biology and crystallization communications. 2009 Oct 1; 65 (Pt 10). 996-1000
Adler DH , Phillips JA , Cogan JD , Iverson TM , Schnetz-Boutaud N , Stein JA , Brenner DA , Milne GL , Morrow JD , Boutaud O , Oates JA , The enteropathy of prostaglandin deficiency. Journal of gastroenterology. 2009 ; 44 Suppl 19 1-7
Preininger AM , Funk MA , Oldham WM , Meier SM , Johnston CA , Adhikary S , Kimple AJ , Siderovski DP , Hamm HE , Iverson TM , Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits. Biochemistry. 2009 Mar 31; 48 (12). 2630-42

2008

Tomasiak TM , Maklashina E , Cecchini G , Iverson TM , A threonine on the active site loop controls transition state formation in Escherichia coli respiratory complex II. The Journal of biological chemistry. 2008 May 30; 283 (22). 15460-8

2007

Tomasiak TM , Cecchini G , Iverson TM , Succinate as Donor; Fumarate as Acceptor. EcoSal Plus. 2007 Apr ; 2 (2).

2006

Iverson TM , Evolution and unique bioenergetic mechanisms in oxygenic photosynthesis. Current opinion in chemical biology. 2006 Apr ; 10 (2). 91-100
Maklashina E , Iverson TM , Sher Y , Kotlyar V , Andréll J , Mirza O , Hudson JM , Armstrong FA , Rothery RA , Weiner JH , Cecchini G , Fumarate reductase and succinate oxidase activity of Escherichia coli complex II homologs are perturbed differently by mutation of the flavin binding domain. The Journal of biological chemistry. 2006 Apr 21; 281 (16). 11357-65

2004

Ferreira KN , Iverson TM , Maghlaoui K , Barber J , Iwata S , Architecture of the photosynthetic oxygen-evolving center. Science (New York, N.Y.). 2004 Mar 19; 303 (5665). 1831-8

2003

Cecchini G , Maklashina E , Yankovskaya V , Iverson TM , Iwata S , Variation in proton donor/acceptor pathways in succinate:quinone oxidoreductases. FEBS letters. 2003 Jun 12; 545 (1). 31-8

2002

Doukov TI , Iverson TM , Seravalli J , Ragsdale SW , Drennan CL , A Ni-Fe-Cu center in a bifunctional carbon monoxide dehydrogenase/acetyl-CoA synthase. Science (New York, N.Y.). 2002 Oct 18; 298 (5593). 567-72
Iyer R , Iverson TM , Accardi A , Miller C , A biological role for prokaryotic ClC chloride channels. Nature. 2002 Oct 17; 419 (6908). 715-8
Iverson TM , Luna-Chavez C , Croal LR , Cecchini G , Rees DC , Crystallographic studies of the Escherichia coli quinol-fumarate reductase with inhibitors bound to the quinol-binding site. The Journal of biological chemistry. 2002 May 3; 277 (18). 16124-30

2001

Iverson TM , Arciero DM , Hooper AB , Rees DC , High-resolution structures of the oxidized and reduced states of cytochrome c554 from Nitrosomonas europaea. Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry. 2001 Apr ; 6 (4). 390-7
Strop P , Smith KS , Iverson TM , Ferry JG , Rees DC , Crystal structure of the “cab”-type beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum. The Journal of biological chemistry. 2001 Mar 30; 276 (13). 10299-305

2000

Iverson TM , Luna-Chavez C , Schröder I , Cecchini G , Rees DC , Analyzing your complexes: structure of the quinol-fumarate reductase respiratory complex. Current opinion in structural biology. 2000 Aug ; 10 (4). 448-55
Luna-Chavez C , Iverson TM , Rees DC , Cecchini G , Overexpression, purification, and crystallization of the membrane-bound fumarate reductase from Escherichia coli. Protein expression and purification. 2000 Jun ; 19 (1). 188-96

1999

Iverson TM , Luna-Chavez C , Cecchini G , Rees DC , Structure of the Escherichia coli fumarate reductase respiratory complex. Science (New York, N.Y.). 1999 Jun 18; 284 (5422). 1961-6

1998

Iverson TM , Arciero DM , Hsu BT , Logan MS , Hooper AB , Rees DC , Heme packing motifs revealed by the crystal structure of the tetra-heme cytochrome c554 from Nitrosomonas europaea. Nature structural biology. 1998 Nov ; 5 (11). 1005-12