Publications
For a complete list of publications, please go to: https://pubmed.ncbi.nlm.nih.gov/?term=delgiorno+ke&sort=date
2023
Wong J, Trinh VQ, Jyotsana N, Baig JF, Revetta F, Shi C, Means AL, DelGiorno KE, and Tan MCB. “Differential spatial distribution of HNF4α isoforms during dysplastic progression of intraductal papillary mucinous neoplasms of the pancreas”. Scientific Reports, 2023. Nov 16;13(1):20088. doi: 10.1038/s41598-023-47238-x.
Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, Jolly MK, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KS, Pe’er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Szeto GL, Tomlin CJ, Yanai I, Zervantonakis IK, and Dueck HR. “Modeling collective cell behavior in cancer: perspectives from an interdisciplinary conversation”. Cell Systems, 2023. Apr 19;14(4):252-257. doi: 10.1016/j.cels.2023.03.002.
DelGiorno KE. “CD73 is a critical immune checkpoint in a molecular subtype of pancreatic cancer”. Commentary on Faraoni et al. Cancer Research, 2023. Apr 4;83(7):977-978. doi: 10.1158/0008-5472.CAN-23-0268.
Cephas A, Hwang WL, Maitra A, Parnas O, and DelGiorno KE. “It is better to light a candle than to curse the darkness: Single cell transcriptomics sheds new light on pancreas biology and disease”. Gut, 2023. Invited review. Mar 30:gutjnl-2022-329313. doi: 10.1136/gutjnl-2022-329313. Named top viewed Gut paper 2023 from June 2023.
O’Brien BJ, Faraoni, EY, Strickland LN, Ma Z, Mota V, Mota S, Chen X, Mills T, Eltzschig HK, DelGiorno KE, Bailey-Lundberg JM. “Adenosine signaling promotes resolution of neutrophil-mediated tissue injury and restrains metaplasia in pancreatitis”. The FASEB Journal, 2023. Jan;37(1):e22684. doi: 10.1096/fj.202201537R.
2022
Trinh VQ, Roland J, Wong J, Revetta F, Patel K, Shi C, DelGiorno KE, Carter B, and Tan MCB. “Peak density of immature nerve cells occurs with high-grade dysplasia in intraductal papillary mucinous neoplasms of the pancreas”. Journal of Pathology, 2022. June 10. doi: 10.1002/path.5978.
O’Leary CE, Ma Z, Culpepper T, Novak SW, and DelGiorno KE. “New insights into tuft cell formation: Implications for structure-function relationships”. Current Opinion in Cell Biology, 2022. Apr 22;76:102082.
Luhtala N, and DelGiorno KE. “Women in Gastrointestinal Sciences: 2021”. Frontiers in Physiology, 2022. Oct 19; 13:1048724.
Caplan LR*, Vavinskaya V*, Gelikman DG, Jyotsana N, Trinh VQ, Olive KP, Tan MCB, and DelGiorno KE. “Enteroendocrine cell formation is an early event in pancreatic tumorigenesis”. Frontiers in Physiology, 2022. April 27;12:865452. Part of the Women in Gastrointestinal Sciences series. *These authors contributed equally.
Jyotsana N, Ta KT, and DelGiorno KE. “The Role of Cystine/Glutamate Antiporter SLC7A11/xCT in the Pathophysiology of Cancer”. Frontiers in Oncology, 2022. Feb 23;12:858462. Part of the Women in Gastrointestinal Sciences series. Named Top 10 viewed review article in 2022 by Frontiers in Oncology.
Gubbala VB, Jyotsana N, Trinh VQ, Maurer HC, Naeem RF, Lytle NK, Ma Z, Zhao S, Lin W, Han Haiyong, Shi Y, Hunter T, Singh PK, Olive KP, Tan MCB, Kaech SM, Wahl GM, and DelGiorno KE. “Eicosanoids in the pancreatic tumor microenvironment – a multicellular, multifaceted progression”. Gastro Hep Advances, 2022. 1(4):682-697. Named a Top 15 high-impact basic science research article of 2022 by the American Gastroenterological Association.
Ma Z, Lytle NK, Chen B, Jyotsana N, Novak SW, Cho CJ, Caplan L, Ben-Levy O, Neininger AC, Burnette DT, Trinh VQ, Tan MCB, Patterson EA, Arrojo e Drigo R, Giraddi RR, Ramos C, Means AL, Matsumoto I, Manor U, Mills JC, Goldenring JR, Lau KS, Wahl GM, and DelGiorno KE. “Single cell transcriptomics reveals a conserved metaplasia program in pancreatic injury”. Gastroenterology, 2022. 162(2):604-620. Reported on in The Scientist: https://www.the-scientist.com/news-opinion/how-pancreas-injuries-can-cause-cancer-in-mice-69393
2020
DelGiorno KE, Chung C, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O’Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, and Wahl GM. “Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2”. Gastroenterology, 2020. 159(5):1866-1881. Named in the Top 20 list of 2020 for Paradigm-Shifting Research in Gastroenterology, Hepatology, and Nutrition by the Gastroenterology Board of Editors. Reported on in Nature Reviews, Gastroenterology and Hepatology: https://www.nature.com/articles/s41575-020-00358-5
Badgley MA, Kremer D, Maurer HC, DelGiorno KE, Lee H, Purohit V, Sagalovskiy I, Ma A, Kapillian J, Firl CEM, Decker AR, Sastra SA, Palermo CF, Andrade LR, Sajjakulnukit P, Zhang L, Tolstyka Z, Hirschorn T, Lamb C, Liu T, Gu W, Seeley ES, Stone E, Georgiou G, Manor U, Iuga A, Wahl GM, Stockwell BR, Lyssiotis CA, and Olive KP. “Cysteine depletion induces pancreatic tumor ferroptosis in mice”. Science, 2020. 368(6486):85-59.
DelGiorno KE* and Naeem RF*, Fang HL, Chung C, Ramos C, Luhtala N, O’Connor C, Hunter T, Manor U, and Wahl G#. “Tuft cell formation reflects epithelial plasticity in pancreatic injury; implications for modeling human pancreatitis”. Frontiers in Physiology, 2020. *Co-first author.
2019
Shi Y, Gao W, Lytle NK, Huang P, Yuan X, Dann A, Ridinger M, DelGiorno KE, Antal CE, Liang G, Atkins AR, Erikson G, Sun H, Meisenhelder J, Terenziani E, Woo G, Fang L, Santisakultarm T, Manor U, Xu R, Becerra CR, Borazanci E, Von Hoff DD, Grandgenett PM, Hollingsworth MA, Leblanc M, Umetsu SE, Collisson EA, Scadeng M, Lowy AM, Donahue TR, Tannishtha R, Downes M, Evans RM, Wahl GM, Pawson T, Tian R, and Hunter T. “Targeting LIF-mediated paracrine interaction for pancreatic cancer therapy and monitoring”. Nature, 2019. 569(7754):131-135.
2017
Saison-Ridinger M, DelGiorno KE, Zhang T, Kraus A, French R, Jaquish D, Tsui C, Erikson G, Shokhirev M, Liddle C, Yu R, Downes M, Evans RM, Saghatelian A, Lowy AM, and Wahl GM. “Reprogramming pancreatic stellate cells via p53 activation: A putative target for pancreatic cancer therapy”. Plos One, 2017. 6:12(12):e0189051.
2016
Dufort CC* and DelGiorno KE*, Carlson MA, Osgood RJ, Zhoa C, Huang Z, Thompson CB, Connor RJ, Thanos CD, Brockenbrough CJ, Provenzano PP, Frost GI, Shepard HM, and Hingorani SR. “Interstitial pressure in pancreatic ductal adenocarcinoma is dominated by a gel-fluid phase”. Biophysical Journal, 2016. 110:2106-2119. *Co-first author.
Dufort CC, DelGiorno KE, and Hingorani SR. “Mounting pressure in the microenvironment: Fluids, solids, and cells in pancreatic ductal adenocarcinoma”. Gastroenterology, 2016. 150:1545-1557.
Liou GY, Doppler H, DelGiorno KE, Zhang L, Leitges M, Crawford HC, Murphy MP, and Storz P. “Mutant KRas-induced mitochondrial oxidative stress in acinar cells upregulates autocrine EGFR signaling to drive formation of pancreatic precancerous lesions”. Cell Reports, 2016. 14(10):2325-36
2015
Whittle MC, Izeradjene K, Rani PG, Feng L, Carlson MA, DelGiorno KE, Wood LD, Goggins M, Hruban RH, Chang AE, Calses P, Thorsen SM, and Hingorani SR. “RUNX3 controls a metastatic switch in pancreatic ductal adenocarcinoma”. Cell, 2015. 161:1-16.
2014
Wu CC, Carpenter ES, Takeuchi KK, Halbrook CJ, Peverley LV, Bien H, Hall JC, DelGiorno KE, Pal D, Song Y, Shi C, Lin RZ and Crawford HC. “PI3K regulation of RAC1 is required for Kras-induced pancreatic tumorigenesis”. Gastroenterology, 2014. 147:1405-1416.
DelGiorno KE, Carlson M, Osgood R, Provenzano PP, Brockenbrough S, Thompson CB, Shepard HM, Frost GI, Potter JD and Hingorani SR. “Response to Chauhan et al.: Interstitial pressure and vascular collapse in pancreas cancer – fluids and solids, measurement and meaning”. Cancer Cell, 2014. 26: p.16-17.
Stromnes I, DelGiorno KE, Greenburg PD, and Hingorani SR. “Stromal re-engineering to treat pancreas cancer”. Carcinogenesis, 2014. 35: p. 1451-1460.
Bailey JM, DelGiorno KE, and Crawford HC. “The Secret Origins and Surprising Fates of Pancreas Tumors”. Carcinogenesis, 2014. 35: p. 1436-1440.
DelGiorno KE* and Tam JW*, Hall JC, Thotakura G, Crawford HC and van der Velden AWM. “Persistent salmonellosis causes pancreatitis in a murine model of infection”. PLoS One, 2014. 9: p.e92807. * Co-first author.
DelGiorno KE, Hall JC, Takeuchi KK, Pan FC, Halbrook CJ, Washington, MK, Olive KP, Spence JR, Sipos B, Wright CVE, Wells JM, and Crawford HC. “Identification and manipulation of biliary metaplasia in pancreatic tumors”. Gastroenterology, 2014. 146: p.233-244 e5.
2013
Ali WH, Chen Q, DelGiorno KE, Su W, Hall JC, Honqu T, Tian H, Kanaho Y, Di Paolo G, Crawford HC, and Frohman MA. “Deficiencies of the lipid- signaling enzymes phospholipase D1 and D2 alter cytoskeletal organization, macrophage phagocytosis, and cytokine-stimulated neutrophil recruitment”. PLoS One, 2013. 8: p.e55325
2012
Ardito CM, Gruner BM, Takeuchi KK, Lubeseder-Martellato C, Teichmann N, Mazur PK, DelGiorno KE, Carpenter ES, Halbrook CJ, Hall JC, Pal D, Briel T, Herner A, Trajkovic-Arsic M, Sipos B, Liou GY, Storz P, Murray NR, Threadgill DW, Sibilia M, Washington MK, Wilson CL, Schmid RM, Raines EW, Crawford HC and Siveke JT. “EGF receptor is required for KRAS-induced pancreatic tumorigenesis”. Cancer Cell, 2012. 22: p.304-317.
2010
Bombardelli L, Carpenter ES, Wu AP, Alston N, DelGiorno KE, and Crawford HC. “Pancreas-specific ablation of beta1 integrin induces tissue degeneration by disrupting acinar cell polarity”. Gastroenterology, 2010. 138: p.2531-40, 2540 e1-4.