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Weaver Laboratory


Weaver Lab Publications

2019

Jimenez L , Yu H , McKenzie AJ , Franklin JL , Patton JG , Liu Q , Weaver AM , Quantitative Proteomic Analysis of Small and Large Extracellular Vesicles (EVs) Reveals Enrichment of Adhesion Proteins in Small EVs Journal of proteome research. 2019 Jan 23; 18 (3). 947-959

2018

Sato S , Weaver AM , Extracellular vesicles: important collaborators in cancer progression Essays in biochemistry. 2018 May 15; 62 (2). 149-163

2017

Sung BH , Weaver AM , Exosome secretion promotes chemotaxis of cancer cells Cell adhesion & migration. 2017 Jan 27; 11 (2). 187-195

2016

Maas SLN , Breakefield XO , Weaver AM , Extracellular Vesicles: Unique Intercellular Delivery Vehicles Trends in cell biology. 2016 Dec 13; 27 (3). 172-188
Sinha S , Hoshino D , Hong NH , Kirkbride KC , Grega-Larson NE , Seiki M , Tyska MJ , Weaver AM , Cortactin promotes exosome secretion by controlling branched actin dynamics The Journal of cell biology. 2016 Jul 11; 214 (2). 197-213
McKenzie AJ , Hoshino D , Hong NH , Cha DJ , Franklin JL , Coffey RJ , Patton JG , Weaver AM , KRAS-MEK Signaling Controls Ago2 Sorting into Exosomes Cell reports. 2016 Apr 21; 15 (5). 978-987

2015

Parekh A , Weaver AM , Regulation of invadopodia by mechanical signaling Experimental cell research. 2015 Nov 04; 343 (1). 89-95
Patton JG , Franklin JL , Weaver AM , Vickers K , Zhang B , Coffey RJ , Ansel KM , Blelloch R , Goga A , Huang B , L'Etoille N , Raffai RL , Lai CP , Krichevsky AM , Mateescu B , Greiner VJ , Hunter C , Voinnet O , McManus MT , Biogenesis, delivery, and function of extracellular RNA Journal of extracellular vesicles. 2015 Aug 28; 4 27494
French CL , Ye F , Revetta F , Zhang B , Coffey RJ , Washington MK , Deane NG , Beauchamp RD , Weaver AM , Linking patient outcome to high throughput protein expression data identifies novel regulators of colorectal adenocarcinoma aggressiveness F1000Research. 2015 Apr 24; 4 99
Young CD , Zimmerman LJ , Hoshino D , Formisano L , Hanker AB , Gatza ML , Morrison MM , Moore PD , Whitwell CA , Dave B , Stricker T , Bhola NE , Silva GO , Patel P , Brantley-Sieders DM , Levin M , Horiates M , Palma NA , Wang K , Stephens PJ , Perou CM , Weaver AM , O'Shaughnessy JA , Chang JC , Park BH , Liebler DC , Cook RS , Arteaga CL , Activating PIK3CA Mutations Induce an Epidermal Growth Factor Receptor (EGFR)/Extracellular Signal-regulated Kinase (ERK) Paracrine Signaling Axis in Basal-like Breast Cancer Molecular & cellular proteomics : MCP. 2015 May 07; 14 (7). 1959-76
Sung BH , Ketova T , Hoshino D , Zijlstra A , Weaver AM , Directional cell movement through tissues is controlled by exosome secretion Nature communications. 2015 May 13; 6 7164
Cha DJ , Franklin JL , Dou Y , Liu Q , Higginbotham JN , Demory Beckler M , Weaver AM , Vickers K , Prasad N , Levy S , Zhang B , Coffey RJ , Patton JG , KRAS-dependent sorting of miRNA to exosomes eLife. 2015 Jul 01; 4 e07197
Koshikawa N , Hoshino D , Taniguchi H , Minegishi T , Tomari T , Nam SO , Aoki M , Sueta T , Nakagawa T , Miyamoto S , Nabeshima K , Weaver AM , Seiki M , Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein Cancer research. 2015 Jun 30; 75 (16). 3327-39

2014

Ryzhov S , Sung BH , Zhang Q , Weaver A , Gumina RJ , Biaggioni I , Feoktistov I , Role of adenosine A2B receptor signaling in contribution of cardiac mesenchymal stem-like cells to myocardial scar formation Purinergic signalling. 2014 Mar 01; 10 (3). 477-86
Lee B , Zhou X , Riching K , Eliceiri KW , Keely PJ , Guelcher SA , Weaver AM , Jiang Y , A three-dimensional computational model of collagen network mechanics PloS one. 2014 Nov 11; 9 (11). e111896
Riching KM , Cox BL , Salick MR , Pehlke C , Riching AS , Ponik SM , Bass BR , Crone WC , Jiang Y , Weaver AM , Eliceiri KW , Keely PJ , 3D collagen alignment limits protrusions to enhance breast cancer cell persistence Biophysical journal. 2014 Dec 02; 107 (11). 2546-58
Cleghorn WM , Branch KM , Kook S , Arnette C , Bulus N , Zent R , Kaverina I , Gurevich EV , Weaver AM , Gurevich VV , Arrestins regulate cell spreading and motility via focal adhesion dynamics Molecular biology of the cell. 2014 Dec 24; 26 (4). 622-35

2013

Hoshino D , Branch KM , Weaver AM , Signaling inputs to invadopodia and podosomes Journal of cell science. 2013 Jul 10; 126 (Pt 14). 2979-89
Bryce NS , Reynolds AB , Koleske AJ , Weaver AM , WAVE2 regulates epithelial morphology and cadherin isoform switching through regulation of Twist and Abl PloS one. 2013 May 15; 8 (5). e64533
Benesh EC , Miller PM , Pfaltzgraff ER , Grega-Larson NE , Hager HA , Sung BH , Qu X , Baldwin HS , Weaver AM , Bader DM , Bves and NDRG4 regulate directional epicardial cell migration through autocrine extracellular matrix deposition Molecular biology of the cell. 2013 Sep 18; 24 (22). 3496-510
Hoshino D , Kirkbride KC , Costello K , Clark ES , Sinha S , Grega-Larson N , Tyska MJ , Weaver AM , Exosome secretion is enhanced by invadopodia and drives invasive behavior Cell reports. 2013 Nov 27; 5 (5). 1159-68

2012

Kirkbride KC , Hong NH , French CL , Clark ES , Jerome WG , Weaver AM , Regulation of late endosomal/lysosomal maturation and trafficking by cortactin affects Golgi morphology Cytoskeleton (Hoboken, N.J.). 2012 Jul 31; 69 (9). 625-43
Branch KM , Hoshino D , Weaver AM , Adhesion rings surround invadopodia and promote maturation Biology open. 2012 Jun 12; 1 (8). 711-22
Hoshino D , Jourquin J , Emmons SW , Miller T , Goldgof M , Costello K , Tyson DR , Brown B , Lu Y , Prasad NK , Zhang B , Mills GB , Yarbrough WG , Quaranta V , Seiki M , Weaver AM , Network analysis of the focal adhesion to invadopodia transition identifies a PI3K-PKCα invasive signaling axis Science signaling. 2012 Sep 11; 5 (241). ra66

2011

Kirkbride KC , Sung BH , Sinha S , Weaver AM , Cortactin: a multifunctional regulator of cellular invasiveness Cell adhesion & migration. 2011 Mar 01; 5 (2). 187-98

2010

Rejniak KA , Wang SE , Bryce NS , Chang H , Parvin B , Jourquin J , Estrada L , Gray JW , Arteaga CL , Weaver AM , Quaranta V , Anderson AR , Linking changes in epithelial morphogenesis to cancer mutations using computational modeling PLoS computational biology. 2010 Aug 26; 6 (8).
Potdar AA , Jeon J , Weaver AM , Quaranta V , Cummings PT , Human mammary epithelial cells exhibit a bimodal correlated random walk pattern PloS one. 2010 Mar 10; 5 (3). e9636

2009

Parekh A , Weaver AM , Regulation of cancer invasiveness by the physical extracellular matrix environment Cell adhesion & migration. 2009 Jul 27; 3 (3). 288-92
Weaver AM , Regulation of cancer invasion by reactive oxygen species and Tks family scaffold proteins Science signaling. 2009 Sep 15; 2 (88). pe56
Anderson AR , Hassanein M , Branch KM , Lu J , Lobdell NA , Maier J , Basanta D , Weidow B , Narasanna A , Arteaga CL , Reynolds AB , Quaranta V , Estrada L , Weaver AM , Microenvironmental independence associated with tumor progression Cancer research. 2009 Nov 03; 69 (22). 8797-806

2008

Weaver AM , Cortactin in tumor invasiveness Cancer letters. 2008 Apr 10; 265 (2). 157-66
Clark ES , Weaver AM , A new role for cortactin in invadopodia: regulation of protease secretion European journal of cell biology. 2008 Mar 14; 87 (8-9). 581-90
Enderling H , Alexander NR , Clark ES , Branch KM , Estrada L , Crooke C , Jourquin J , Lobdell N , Zaman MH , Guelcher SA , Anderson AR , Weaver AM , Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence Biophysical journal. 2008 May 30; 95 (5). 2203-18
Wegner AM , Nebhan CA , Hu L , Majumdar D , Meier KM , Weaver AM , Webb DJ , N-wasp and the arp2/3 complex are critical regulators of actin in the development of dendritic spines and synapses The Journal of biological chemistry. 2008 Apr 21; 283 (23). 15912-20
Potdar AA , Lu J , Jeon J , Weaver AM , Cummings PT , Bimodal analysis of mammary epithelial cell migration in two dimensions Annals of biomedical engineering. 2008 Nov 04; 37 (1). 230-45
Alexander NR , Branch KM , Parekh A , Clark ES , Iwueke IC , Guelcher SA , Weaver AM , Extracellular matrix rigidity promotes invadopodia activity Current biology : CB. 2008 Aug 21; 18 (17). 1295-1299
Clark ES , Brown B , Whigham AS , Kochaishvili A , Yarbrough WG , Weaver AM , Aggressiveness of HNSCC tumors depends on expression levels of cortactin, a gene in the 11q13 amplicon Oncogene. 2008 Oct 20; 28 (3). 431-44

2006

Weaver AM , Invadopodia: specialized cell structures for cancer invasion Clinical & experimental metastasis. 2006 Jul 09; 23 (2). 97-105

Cooper JA , Wear MA , Weaver AM , Arp2/3 complex: advances on the inner workings of a molecular machine Cell. ; 107 (6). 703-5
Weaver AM , Young ME , Lee WL , Cooper JA , Integration of signals to the Arp2/3 complex Current opinion in cell biology. ; 15 (1). 23-30
Weaver AM , Cytoskeletal interactions with the outside world Developmental cell. ; 9 (1). 35-8
Quaranta V , Weaver AM , Cummings PT , Anderson AR , Mathematical modeling of cancer: the future of prognosis and treatment Clinica chimica acta; international journal of clinical chemistry. ; 357 (2). 173-9
Weaver AM , Invadopodia Current biology : CB. ; 18 (9). R362-4
Sung BH , Weaver A , Cell-cell fusion: a new function for invadosomes Current biology : CB. ; 21 (3). R121-3
Sung BH , Weaver AM , Regulation of lysosomal secretion by cortactin drives fibronectin deposition and cell motility Bioarchitecture. ; 1 (6). 257-260
Weaver AM , Page JM , Guelcher SA , Parekh A , Synthetic and tissue-derived models for studying rigidity effects on invadopodia activity Methods in molecular biology (Clifton, N.J.). ; 1046 171-89
Brábek J , Constancio SS , Shin NY , Pozzi A , Weaver AM , Hanks SK , CAS promotes invasiveness of Src-transformed cells Oncogene. ; 23 (44). 7406-15
Bryce NS , Clark ES , Leysath JL , Currie JD , Webb DJ , Weaver AM , Cortactin promotes cell motility by enhancing lamellipodial persistence Current biology : CB. ; 15 (14). 1276-85
Anderson AR , Weaver AM , Cummings PT , Quaranta V , Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment Cell. ; 127 (5). 905-15
Clark ES , Whigham AS , Yarbrough WG , Weaver AM , Cortactin is an essential regulator of matrix metalloproteinase secretion and extracellular matrix degradation in invadopodia Cancer research. ; 67 (9). 4227-35
Jeon J , Alexander NR , Weaver AM , Cummings PT , Protrusion of a Virtual Model Lamellipodium by Actin Polymerization: A Coarse-grained Langevin Dynamics Model Journal of statistical physics. ; 133 (1). 79-100
Liu S , Yamashita H , Weidow B , Weaver AM , Quaranta V , Laminin-332-beta1 integrin interactions negatively regulate invadopodia Journal of cellular physiology. ; 223 (1). 134-42
Parekh A , Ruppender NS , Branch KM , Sewell-Loftin MK , Lin J , Boyer PD , Candiello JE , Merryman WD , Guelcher SA , Weaver AM , Sensing and modulation of invadopodia across a wide range of rigidities Biophysical journal. ; 100 (3). 573-582
Sung BH , Zhu X , Kaverina I , Weaver AM , Cortactin controls cell motility and lamellipodial dynamics by regulating ECM secretion Current biology : CB. ; 21 (17). 1460-9
Wirtz ED , Hoshino D , Maldonado AT , Tyson DR , Weaver AM , Response of head and neck squamous cell carcinoma cells carrying PIK3CA mutations to selected targeted therapies JAMA otolaryngology-- head & neck surgery. ; 141 (6). 543-9
Hong NH , Qi A , Weaver AM , PI(3,5)P2 controls endosomal branched actin dynamics by regulating cortactin-actin interactions The Journal of cell biology. ; 210 (5). 753-69