AUTHORS
Zaganjor
E ,
Vyas
S ,
Haigis
MC .
Cell Chemical Biology. 2017 6 22; 24(6).
656-658
- PMID: 28644956[PubMed].
ABSTRACT
In a recent issue of Cell Metabolism, Anderson et al. (2017) report that SIRT4 regulates insulin sensitivity in the pancreas via activation of methylcrotonyl-CoA carboxylase 1 (MCCC1) by removal of dicarboxyacyl-lysine modifications. Thus, SIRT4 activates leucine catabolism and causes decreased secretion of insulin from the pancreas