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Zaganjor Lab


2023

Crabtree A , Neikirk K , Marshall G , Vang L , Whiteside J , Williams Q , Altamura T , Owens C , Stephens D , Shao B , Koh A , Killion M , Lopez G , Lam J , Rodriguez B , Mungai M , Stanley J , Dean E , Koh J , Gaddy A , Scudese E , Sweetwyne T , Davis J , Zaganjor E , Murray A , Katti P , Damo M , Vue Z , Hinton Jr A , Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue Advanced Biology. 2023 Aug 21;
Vue Z , Neikirk K , Vang L , Garza-Lopez E , Christensen A , Shao J , Lam J , Beasley K , Marshall G , Crabtree A , Anudokem Jr J , Rodriguez B , Kirk B , Bacevac S , Barongan T , Shao B , Stephens C , Kabugi K , Koh H , Koh A , Evans S , Taylor B , Reddy K , Miller-Fleming T , Actkins V , Zaganjor E , Daneshgar N , Murray A , Mobley C , Damo M , Gaddy A , Riggs B , Wanjalla C , Kirabo A , McReynolds M , Gomez A , Phillips A , Exil V , Dai D , Hinton Jr A , Three-dimensional mitochondria reconstructions of murine cardiac muscle changes in size across aging American Journal of Physiology-Heart and Circulatory Physiology. 2023 Nov 1;
Vue Z , Garza-Lopez E , Neikirk K , Katti P , Vang L , Beasley H , Shao J , Marshall G , Crabtree A , Murphy C , Jenkins C , Prasad P , Evans C , Taylor B , Mungai M , Killion M , Stephens D , Christensen A , Lam J , Rodriguez B , Phillips A , Daneshgar N , Koh H , Koh A , Davis J , Devine N , Muhammod S , Scudese E , Arnold R , Chavarin V , Robinson D , Chakraborty M , Gaddy A , Sweetwyne T , Wilson G , Zaganjor E , Kezos J , Dondi C , Reddy K , Glancy B , Kirabo A , Quintana M , Dai D , Ocorr K , Murray A , Damo M , Exil V , Riggs B , Mobley C , Gomez A , McReynolds R , Hinton Jr A , 3D reconstruction of murine mitochondria reveals changes in structure during aging linked to the MICOS complex Aging Cell. 2023 Nov 13;
Shinde A , Nunn R , Wilson A , Chvasta T , Pinette A , Myers W , Peck H , Spinelli B , Zaganjor E , Inhibition of nucleotide biosynthesis disrupts lipid accumulation and adipogenesis Journal of Biological Chemistry. 2023 Mar 22;

2022

Notarangelo G , Spinelli B , Perez M , Baker J , Kurmi K , Elia I , Stopka A , Baquer G , Lin J , Golby J , Joshi S , Baron F , Drijvers M , Georgiev P , Ringel E , Zaganjor E , McBrayer K , Sorger K , Sharpe H , Wucherpfennig W , Santagata S , Agar YR , Suvà L , Haigis C , Oncometabolite d-2HG alters T cell metabolism to impair CD8+ T cell function. Science. 2022 Sep 30;
Nunn ER , Shinde AB , Zaganjor E , Weighing in on Adipogenesis Frontiers in Physiology. 2022 Feb 22; 13 821278
Spinelli JB , Zaganjor E , Mitochondrial efficiency directs cell fate Nature Cell Biology. 2022 Feb 24; 24 (2). 125-126

2021

Shinde AB , Zaganjor E , AdipoAtlas: Mapping out human white adipose tissue Cell Reports Medicine. 2021 Oct 19; 2 (10). 100429
Oren Y , Tsabar M , Cuoco MS , Amir-Zilberstein L , Cabanos HF , Hütter JC , Hu B , Thakore PI , Tabaka M , Fulco CP , Colgan W , Cuevas BM , Hurvitz SA , Slamon DJ , Deik A , Pierce KA , Clish C , Hata AN , Zaganjor E , Lahav G , Politi K , Brugge JS , Regev A , Cycling cancer persister cells arise from lineages with distinct programs Nature. 2021 Aug 11; 596 (7873). 576-582
Zaganjor E , Yoon H , Spinelli JB , Nunn ER , Laurent G , Keskinidis P , Sivaloganathan S , Joshi S , Notarangelo G , Mulei S , Chvasta MT , Tucker SA , Kalafut K , van de Ven RAH , Clish CB , Haigis MC , SIRT4 is an early regulator of branched-chain amino acid catabolism that promotes adipogenesis Cell Reports. 2021 Jul 13; 36 (2).

2020

Yoon H , Spinelli JB , Zaganjor E , Wong SJ , German NJ , Randall EC , Dean A , Clermont A , Paulo JA , Garcia D , Li H , Rombold O , Agar NYR , Goodyear LJ , Shaw RJ , Gygi SP , Auwerx J , Haigis MC , PHD3 Loss Promotes Exercise Capacity and Fat Oxidation in Skeletal Muscle Cell Metabolism. 2020 Jul 9; S1550-4131 (20). 30318-1
Qiao S , Koh SB , Vivekanandan V , Salunke D , Patra KC , Zaganjor E , Ross K , Mizukami Y , Jeanfavre S , Chen A , Mino-Kenudson M , Ramaswamy S , Clish C , Haigis M , Bardeesy N , Ellisen LW , REDD1 loss reprograms lipid metabolism to drive progression of RASK mutant tumors Genes & Development. 2020 Apr 9; 34 (11-12). 751-766

2018

Gonzalez Herrera KN , Zaganjor E , Ishikawa Y , Spinelli JB , Yoon H , Lin JR , Satterstrom FK , Ringel A , Mulei S , Souza A , Gorham JM , Benson CC , Seidman JG , Sorger PK , Clish CB , Haigis MC , Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3 Cell Reports. 2018 Feb 20; 22 (8). 1945-1955
Escudero S , Zaganjor E , Lee S , Mill CP , Morgan AM , Crawford EB , Chen J , Wales TE , Mourtada R , Luccarelli J , Bird GH , Steidl U , Engen JR , Haigis MC , Opferman JT , Walensky LD , Dynamic Regulation of Long-Chain Fatty Acid Oxidation by a Noncanonical Interaction between the MCL-1 BH3 Helix and VLCAD Molecular Cell. 2018 Mar 1; 69 (5). 729-743
Lee JJ , van de Ven RAH , Zaganjor E , Ng MR , Barakat A , Demmers JJPG , Finley LWS , Gonzalez Herrera KN , Hung YP , Harris IS , Jeong SM , Danuser G , McAllister SS , Haigis MC , Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. Proc Natl Acad Sci USA. 2018 Jul 3; 115 (27). 7057-7062

2017

Zaganjor E , Vyas S , Haigis MC , SIRT4 Is a Regulator of Insulin Secretion Cell Chemical Biology. 2017 Jun 22; 24 (6). 656-658
Zaganjor E , Spinelli JB , Haigis MC , Strength in numbers: Phosphofructokinase polymerization prevails in the liver Journal of Cell Biology. 2017 Aug 7; 216 (8). 2239-2241

2016

McReynolds AC , Karra AS , Li Y , Lopez ED , Turjanski AG , Dioum E , Lorenz K , Zaganjor E , Stippec S , McGlynn K , Earnest S , Cobb MH , Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding Biochemistry. 2016 Mar 29; 55 (12). 1909-17
Vyas S , Zaganjor E , Haigis MC , Mitochondria and Cancer Cell. 2016 Jul 28; 166 (3). 555-556
German NJ , Yoon H , Yusuf RZ , Morgan JP , Finley LW , Laurent G , Haas W , Satterstrom FK , Guarnerio J , Zaganjor E , Santos D , Pandolfi PP , Beck AH , Gygi SP , Scadden DT , Kaelin WG Jr , Haigis MC , PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2 Molecular Cell. 2016 Sep 15; 63 (6). 1006-20
Yang W , Nagasawa K , Münch C , Xu Y , Satterstrom K , Jeong S , Hayes SD , Jedrychowski MP , Vyas FS , Zaganjor E , Guarani V , Ringel AE , Gygi SP , Harper JW , Haigis MC , Mitochondrial Sirtuin Network Reveals Dynamic SIRT3-Dependent Deacetylation in Response to Membrane Depolarization Cell. 2016 Nov 3; 167 (4). 985-1000

2014

Zaganjor E , Osborne JK , Weil LM , Diaz-Martinez LA , Gonzales JX , Singel SM , Larsen JE , Girard L , Minna JD , Cobb MH , Ras regulates kinesin 13 family members to control cell migration pathways in transformed human bronchial epithelial cells Oncogene. 2014 Nov 20; 33 (47). 5457-66
Singel SM , Cornelius C , Zaganjor E , Batten K , Sarode VR , Buckley DL , Peng Y , John GB , Li HC , Sadeghi N , Wright WE , Lum L , Corson TW , Shay JW , KIF14 promotes AKT phosphorylation and contributes to chemoresistance in triple-negative breast cancer. Neoplasia. 2014 Mar ; 16 (3). 247-56
E Zaganjor , Weil LM , Gonzales JX , Minna JD , Cobb MH , Ras transformation uncouples the kinesin-coordinated cellular nutrient response Proc Natl Acad Sci USA. 2014 Jul 22; 111 (29). 10568-73

2013

Wauson EM , Zaganjor E , Cobb MH , Amino acid regulation of autophagy through the GPCR TAS1R1-TAS1R3 Autophagy. 2013 Mar ; 9 (3). 418-9
Klein AM , Zaganjor E , Cobb MH , Chromatin-tethered MAPKs Curr Opin Cell Biol. 2013 Apr ; 25 (2). 272-7

2012

Osbourne JK , Zaganjor E , Cobb MH , Signal control through Raf: in sickness and in health Cell Research. 2012 Jan ; 22 (1). 14-22
Wauson EM , Zaganjor E , Lee AY , Guerra ML , Ghosh AB , Bookout AL , Chambers CP , Jivan A , McGlynn K , Hutchinson MR , Deberardinis RJ , Cobb MH , The G protein- coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy Molecular Cell. 2012 Sep 28; 47 (6). 851-62

2008

Lawrence MC , Jivan A , Shao C , Duan L , Goad D , Zaganjor E , Osborne J , McGlynn K , Stippec S , Earnest S , Chen W , Cobb MH , The roles of MAPKs in disease Cell Research. 2008 Apr ; 18 (4). 436-42

2007

Yagoda N , von Rechenberg M , Zaganjor E , Bauer AJ , Yang WS , Fridman DJ , Wolpaw AL , Smukste I , Peltier JM , Boniface JJ , Smith R , Lessnick SL , Sahasrabudhe S , Stockwell BR , RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels Nature. 2007 Jun 14; 447 (7146). 864-8

Pannek M , Alhalabi Z , Tomaselli D , Menna M , Fiorentino F , Robaa D , Weyand M , Puhlmann M , Tomassi S , Barreca F , Tafani M , Zaganjor E , Haigis C , Sippl W , Rotili D , Mai A , Steegborn C , Specific Inhibitors of Mitochondrial Deacylase Sirtuin 4 Endowed with Cellular Activity ;