AUTHORS
Osbourne
JK ,
Zaganjor
E ,
Cobb
MH .
Cell Research. 2012 1 ; 22(1).
14-22
- PMID: 22143568[PubMed].
- PMCID: PMC3351917.
ABSTRACT
The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is the prototype mammalian mitogen-activated protein kinase (MAPK) signaling cascade that regulates a number of processes, including proliferation, differentiation, survival, migration, stress responses and apoptosis. How this seemingly linear cascade is modulated to achieve a specific cellular function has been a main focus of the field. In this review, we describe new as well as old findings in the regulation of the ERK1/2 pathway in normal and disease states via MAP3Ks.