AUTHORS
Zaganjor
E ,
Spinelli
JB ,
Haigis
MC .
Journal of Cell Biology. 2017 8 7; 216(8).
2239-2241
- PMID: 28716843[PubMed].
- PMCID: PMC5551721.
ABSTRACT
Numerous metabolic enzymes assemble into filamentous structures, which are thought to serve additional regulatory functions. In this issue, Webb et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb.201701084) show that the liver-specific isoform of phosphofructokinase-1 forms filaments in vitro and localizes as puncta in cells along the plasma membrane. This suggests spatial organization of glycolysis in higher organisms.