Pores for thought: nuclear pore complex proteins.
AUTHORS
Rout| Wente
MP| SRM P| S R .
Trends in cell biology. 1994 10 ; 4(10).
357-65
- PMID: 14731624[PubMed].
ABSTRACT
Nuclear pore complexes (NPCs) are enormous macromolecular structures that mediate the active exchange of proteins and RNPs between the nucleus and cytoplasm. Recent work has resulted in a windfall of identified NPC polypeptides, many with unique sequences. Several of the proteins have been shown to be part of extended cytoplasmic and nucleoplasmic NPC filaments. Biochemical, structural and genetic studies on NPC proteins are just beginning to allow an understanding of how they associate into a functional organelle.
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