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A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export.


York| Odom| Murphy| Ives| Wente JD| AR| R| EB| SRJ D| A R| R| E B| S R . Science (New York, N.Y.). 1999 7 2; 285(5424). 96-100


In order to identify additional factors required for nuclear export of messenger RNA, a genetic screen was conducted with a yeast mutant deficient in a factor Gle1p, which associates with the nuclear pore complex (NPC). The three genes identified encode phospholipase C and two potential inositol polyphosphate kinases. Together, these constitute a signaling pathway from phosphatidylinositol 4, 5-bisphosphate to inositol hexakisphosphate (IP6). The common downstream effects of mutations in each component were deficiencies in IP6 synthesis and messenger RNA export, indicating a role for IP6 in GLE1 function and messenger RNA export.

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