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Publications

Huseman, ED, Byl, JAW, Chapp, SM, Schley, ND, Osheroff, N, Townsend, SD et al.. Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids. ACS Cent Sci. 2021;7 (8):1327-1337. doi: 10.1021/acscentsci.1c00040. PubMed PMID:34471677 PubMed Central PMC8393218.

Osheroff, N. The COVID-19 Pandemic: a Year Lost, or a Year Found?. Med Sci Educ. 2021; :1-6. doi: 10.1007/s40670-021-01392-x. PubMed PMID:34466278 PubMed Central PMC8390108.

Osheroff, N. Getting stressed over topoisomerase I poisons. Cell Chem Biol. 2021;28 (6):743-745. doi: 10.1016/j.chembiol.2021.04.015. PubMed PMID:34143956 PubMed Central PMC8445809.

Vann, KR, Oviatt, AA, Osheroff, N. Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors. Biochemistry. 2021;60 (21):1630-1641. doi: 10.1021/acs.biochem.1c00240. PubMed PMID:34008964 PubMed Central PMC8209676.

Collins, JA, Osheroff, N. 1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases. Chem Res Toxicol. 2021;34 (4):1082-1090. doi: 10.1021/acs.chemrestox.0c00492. PubMed PMID:33760604 PubMed Central PMC8058326.

Ortega, JA, Arencibia, JM, Minniti, E, Byl, JAW, Franco-Ulloa, S, Borgogno, M et al.. Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β. J Med Chem. 2020;63 (21):12873-12886. doi: 10.1021/acs.jmedchem.0c00774. PubMed PMID:33079544 PubMed Central PMC7668297.

Gibson, EG, Oviatt, AA, Osheroff, N. Two-Dimensional Gel Electrophoresis to Resolve DNA Topoisomers. Methods Mol Biol. 2020;2119 :15-24. doi: 10.1007/978-1-0716-0323-9_2. PubMed PMID:31989511 PubMed Central PMC7012906.

Gibson, EG, Oviatt, AA, Cacho, M, Neuman, KC, Chan, PF, Osheroff, N et al.. Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV. Biochemistry. 2019;58 (44):4447-4455. doi: 10.1021/acs.biochem.9b00805. PubMed PMID:31617352 PubMed Central PMC7450530.

Heintzman, DR, Campos, LV, Byl, JAW, Osheroff, N, Dewar, JM. Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination. Cell Rep. 2019;29 (2):422-436.e5. doi: 10.1016/j.celrep.2019.08.097. PubMed PMID:31597101 PubMed Central PMC6919565.

Kuriappan, JA, Osheroff, N, De Vivo, M. Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II. J Chem Inf Model. 2019;59 (9):4007-4017. doi: 10.1021/acs.jcim.9b00605. PubMed PMID:31449404 PubMed Central PMC6800198.

Dalvie, ED, Gopas, J, Golan-Goldhirsh, A, Osheroff, N. 6,6'-Dihydroxythiobinupharidine as a poison of human type II topoisomerases. Bioorg Med Chem Lett. 2019;29 (15):1881-1885. doi: 10.1016/j.bmcl.2019.06.003. PubMed PMID:31182315 PubMed Central PMC6588444.

Gibson, EG, Bax, B, Chan, PF, Osheroff, N. Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase. ACS Infect Dis. 2019;5 (4):570-581. doi: 10.1021/acsinfecdis.8b00315. PubMed PMID:30757898 PubMed Central PMC6461504.

Jang, Y, Son, H, Lee, SW, Hwang, W, Jung, SR, Byl, JAW et al.. Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA. Cell Chem Biol. 2019;26 (4):502-511.e3. doi: 10.1016/j.chembiol.2018.12.003. PubMed PMID:30713098 PubMed Central PMC6474810.

Oviatt, AA, Kuriappan, JA, Minniti, E, Vann, KR, Onuorah, P, Minarini, A et al.. Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ. Bioorg Med Chem Lett. 2018;28 (17):2961-2968. doi: 10.1016/j.bmcl.2018.07.010. PubMed PMID:30006062 PubMed Central PMC6097886.

Gibson, EG, Blower, TR, Cacho, M, Bax, B, Berger, JM, Osheroff, N et al.. Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons. ACS Infect Dis. 2018;4 (8):1211-1222. doi: 10.1021/acsinfecdis.8b00035. PubMed PMID:29746087 PubMed Central PMC6309371.

Dahlman, KB, Weinger, MB, Lomis, KD, Nanney, L, Osheroff, N, Moore, DE Jr et al.. Integrating Foundational Sciences in a Clinical Context in the Post-Clerkship Curriculum. Med Sci Educ. 2018;28 (1):145-154. . PubMed PMID:29632705 PubMed Central PMC5889049.

Infante Lara, L, Fenner, S, Ratcliffe, S, Isidro-Llobet, A, Hann, M, Bax, B et al.. Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences. Nucleic Acids Res. 2018;46 (5):2218-2233. doi: 10.1093/nar/gky072. PubMed PMID:29447373 PubMed Central PMC5861436.

Bird, EC, Osheroff, N, Pettepher, CC, Cutrer, WB, Carnahan, RH. Using Small Case-Based Learning Groups as a Setting for Teaching Medical Students How to Provide and Receive Peer Feedback. Med Sci Educ. 2017;27 (4):759-765. doi: 10.1007/s40670-017-0461-x. PubMed PMID:29326856 PubMed Central PMC5757314.

Niederhoffer, EC, Cline, SD, Osheroff, N, Simmons, JM, Diekman, AB, Franklin, DS et al.. Teaching Biochemistry and Genetics to Students of Dentistry, Medicine, and Pharmacy 6 International Conference of the Association of Biochemistry Educators (ABE) Clearwater Beach, FL, USA, May 7-11, 2017. Med Sci Educ. 2017;27 (4):855-859. doi: 10.1007/s40670-017-0441-1. PubMed PMID:29291139 PubMed Central PMC5744257.

Ashley, RE, Dittmore, A, McPherson, SA, Turnbough, CL Jr, Neuman, KC, Osheroff, N et al.. Activities of gyrase and topoisomerase IV on positively supercoiled DNA. Nucleic Acids Res. 2017;45 (16):9611-9624. doi: 10.1093/nar/gkx649. PubMed PMID:28934496 PubMed Central PMC5766186.

Ashley, RE, Blower, TR, Berger, JM, Osheroff, N. Recognition of DNA Supercoil Geometry by Mycobacterium tuberculosis Gyrase. Biochemistry. 2017;56 (40):5440-5448. doi: 10.1021/acs.biochem.7b00681. PubMed PMID:28921956 PubMed Central PMC5637011.

Minniti, E, Byl, JAW, Riccardi, L, Sissi, C, Rosini, M, De Vivo, M et al.. Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα. Bioorg Med Chem Lett. 2017;27 (20):4687-4693. doi: 10.1016/j.bmcl.2017.09.011. PubMed PMID:28919339 PubMed Central PMC5623067.

Ashley, RE, Lindsey, RH Jr, McPherson, SA, Turnbough, CL Jr, Kerns, RJ, Osheroff, N et al.. Interactions between Quinolones and Bacillus anthracis Gyrase and the Basis of Drug Resistance. Biochemistry. 2017;56 (32):4191-4200. doi: 10.1021/acs.biochem.7b00203. PubMed PMID:28708938 PubMed Central PMC5560241.

Kristoffersen, EL, Givskov, A, Jørgensen, LA, Jensen, PW, W Byl, JA, Osheroff, N et al.. Interlinked DNA nano-circles for measuring topoisomerase II activity at the level of single decatenation events. Nucleic Acids Res. 2017;45 (13):7855-7869. doi: 10.1093/nar/gkx480. PubMed PMID:28541438 PubMed Central PMC5570003.

Yu, X, Davenport, JW, Urtishak, KA, Carillo, ML, Gosai, SJ, Kolaris, CP et al.. Genome-wide TOP2A DNA cleavage is biased toward translocated and highly transcribed loci. Genome Res. 2017;27 (7):1238-1249. doi: 10.1101/gr.211615.116. PubMed PMID:28385713 PubMed Central PMC5495075.

Infante Lara, L, Sledge, A, Laradji, A, Okoro, CO, Osheroff, N. Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα. Bioorg Med Chem Lett. 2017;27 (3):586-589. doi: 10.1016/j.bmcl.2016.12.011. PubMed PMID:27998679 PubMed Central PMC5241170.

Pettepher, CC, Lomis, KD, Osheroff, N. From Theory to Practice: Utilizing Competency-based Milestones to Assess Professional Growth and Development in the Foundational Science Blocks of a Pre-Clerkship Medical School Curriculum. Med Sci Educ. 2016;26 (3):491-497. doi: 10.1007/s40670-016-0262-7. PubMed PMID:27752401 PubMed Central PMC5064946.

Vann, KR, Ergün, Y, Zencir, S, Oncuoglu, S, Osheroff, N, Topcu, Z et al.. Inhibition of human DNA topoisomerase IIα by two novel ellipticine derivatives. Bioorg Med Chem Lett. 2016;26 (7):1809-12. doi: 10.1016/j.bmcl.2016.02.034. PubMed PMID:26906637 PubMed Central PMC4785065.

Vann, KR, Ekiz, G, Zencir, S, Bedir, E, Topcu, Z, Osheroff, N et al.. Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα. Chem Res Toxicol. 2016;29 (3):415-20. doi: 10.1021/acs.chemrestox.6b00009. PubMed PMID:26894873 PubMed Central PMC4864862.

Aldred, KJ, Blower, TR, Kerns, RJ, Berger, JM, Osheroff, N. Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase. Proc Natl Acad Sci U S A. 2016;113 (7):E839-46. doi: 10.1073/pnas.1525055113. PubMed PMID:26792518 PubMed Central PMC4763725.

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