Publications

Oviatt, AA, Gibson, EG, Huang, J, Mattern, K, Neuman, KC, Chan, PF et al.. Interactions between Gepotidacin and Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting. ACS Infect Dis. 2024;10 (4):1137-1151. doi: 10.1021/acsinfecdis.3c00346. PubMed PMID:38606465 PubMed Central PMC11015057.

Collins, JA, Oviatt, AA, Chan, PF, Osheroff, N. Target-Mediated Fluoroquinolone Resistance in : Actions of Ciprofloxacin against Gyrase and Topoisomerase IV. ACS Infect Dis. 2024;10 (4):1351-1360. doi: 10.1021/acsinfecdis.4c00041. PubMed PMID:38606464 PubMed Central PMC11015056.

Collins, JA, Osheroff, N. Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance. ACS Infect Dis. 2024;10 (4):1097-1115. doi: 10.1021/acsinfecdis.4c00128. PubMed PMID:38564341 PubMed Central PMC11019561.

Haramati, A, Bonaminio, G, Osheroff, N. Professional Identity Formation of Medical Science Educators: An Imperative for Academic Medicine. Med Sci Educ. 2024;34 (1):209-214. doi: 10.1007/s40670-023-01922-9. PubMed PMID:38510409 PubMed Central PMC10948639.

Deweese, JE, Osheroff, N. No Time to Relax and Unwind: Exploration of Topoisomerases and a Growing Field of Study. Int J Mol Sci. 2023;24 (17):. doi: 10.3390/ijms241713080. PubMed PMID:37685888 PubMed Central PMC10487853.

Dauda, SE, Collins, JA, Byl, JAW, Lu, Y, Yalowich, JC, Mitton-Fry, MJ et al.. Actions of a Novel Bacterial Topoisomerase Inhibitor against Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks. Int J Mol Sci. 2023;24 (15):. doi: 10.3390/ijms241512107. PubMed PMID:37569485 PubMed Central PMC10419083.

Brooks, JV, Dickinson, BL, Quesnelle, KM, Bonaminio, GA, Chalk-Wilayto, J, Dahlman, KB et al.. Professional Identity Formation of Basic Science Medical Educators: A Qualitative Study of Identity Supports and Threats. Acad Med. 2023;98 (11S):S14-S23. doi: 10.1097/ACM.0000000000005354. PubMed PMID:37556802 PubMed Central PMC10657385.

Jian, JY, Osheroff, N. Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases. Int J Mol Sci. 2023;24 (13):. doi: 10.3390/ijms241311199. PubMed PMID:37446377 PubMed Central PMC10342825.

Jian, JY, McCarty, KD, Byl, JAW, Guengerich, FP, Neuman, KC, Osheroff, N et al.. Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases. Nucleic Acids Res. 2023;51 (8):3888-3902. doi: 10.1093/nar/gkad190. PubMed PMID:36999602 PubMed Central PMC10164583.

Byl, JAW, Mueller, R, Bax, B, Basarab, GS, Chibale, K, Osheroff, N et al.. A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Gyrase. ACS Infect Dis. 2023;9 (3):706-715. doi: 10.1021/acsinfecdis.3c00012. PubMed PMID:36802491 PubMed Central PMC10006343.

Bird, EC, Pettepher, CC, Ball, MAZ, Goswami, P, Lyons, E, Reed, SC et al.. Zooming into the COVID Era Together. Med Sci Educ. 2022;32 (5):1183-1188. doi: 10.1007/s40670-022-01611-z. PubMed PMID:36124041 PubMed Central PMC9476443.

Dalvie, ED, Stacy, JC, Neuman, KC, Osheroff, N. Recognition of DNA Supercoil Handedness during Catenation Catalyzed by Type II Topoisomerases. Biochemistry. 2022;61 (19):2148-2158. doi: 10.1021/acs.biochem.2c00370. PubMed PMID:36122251 PubMed Central PMC9548324.

Lu, Y, Mann, CA, Nolan, S, Collins, JA, Parker, E, Papa, J et al.. 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. ACS Med Chem Lett. 2022;13 (6):955-963. doi: 10.1021/acsmedchemlett.2c00111. PubMed PMID:35707162 PubMed Central PMC9189870.

Van Ravenstein, SX, Mehta, KP, Kavlashvili, T, Byl, JAW, Zhao, R, Osheroff, N et al.. Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms. EMBO J. 2022;41 (12):e110632. doi: 10.15252/embj.2022110632. PubMed PMID:35578785 PubMed Central PMC9194788.

Govender, P, Müller, R, Singh, K, Reddy, V, Eyermann, CJ, Fienberg, S et al.. Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity. J Med Chem. 2022;65 (9):6903-6925. doi: 10.1021/acs.jmedchem.2c00266. PubMed PMID:35500229 PubMed Central PMC9233935.

Huseman, ED, Byl, JAW, Chapp, SM, Schley, ND, Osheroff, N, Townsend, SD et al.. Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids. ACS Cent Sci. 2021;7 (8):1327-1337. doi: 10.1021/acscentsci.1c00040. PubMed PMID:34471677 PubMed Central PMC8393218.

Osheroff, N. The COVID-19 Pandemic: a Year Lost, or a Year Found?. Med Sci Educ. 2021;31 (Suppl 1):21-26. doi: 10.1007/s40670-021-01392-x. PubMed PMID:34466278 PubMed Central PMC8390108.

Osheroff, N. Getting stressed over topoisomerase I poisons. Cell Chem Biol. 2021;28 (6):743-745. doi: 10.1016/j.chembiol.2021.04.015. PubMed PMID:34143956 PubMed Central PMC8445809.

Vann, KR, Oviatt, AA, Osheroff, N. Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors. Biochemistry. 2021;60 (21):1630-1641. doi: 10.1021/acs.biochem.1c00240. PubMed PMID:34008964 PubMed Central PMC8209676.

Collins, JA, Osheroff, N. 1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases. Chem Res Toxicol. 2021;34 (4):1082-1090. doi: 10.1021/acs.chemrestox.0c00492. PubMed PMID:33760604 PubMed Central PMC8058326.

Ortega, JA, Arencibia, JM, Minniti, E, Byl, JAW, Franco-Ulloa, S, Borgogno, M et al.. Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β. J Med Chem. 2020;63 (21):12873-12886. doi: 10.1021/acs.jmedchem.0c00774. PubMed PMID:33079544 PubMed Central PMC7668297.

Gibson, EG, Oviatt, AA, Osheroff, N. Two-Dimensional Gel Electrophoresis to Resolve DNA Topoisomers. Methods Mol Biol. 2020;2119 :15-24. doi: 10.1007/978-1-0716-0323-9_2. PubMed PMID:31989511 PubMed Central PMC7012906.

Gibson, EG, Oviatt, AA, Cacho, M, Neuman, KC, Chan, PF, Osheroff, N et al.. Bimodal Actions of a Naphthyridone/Aminopiperidine-Based Antibacterial That Targets Gyrase and Topoisomerase IV. Biochemistry. 2019;58 (44):4447-4455. doi: 10.1021/acs.biochem.9b00805. PubMed PMID:31617352 PubMed Central PMC7450530.

Heintzman, DR, Campos, LV, Byl, JAW, Osheroff, N, Dewar, JM. Topoisomerase II Is Crucial for Fork Convergence during Vertebrate Replication Termination. Cell Rep. 2019;29 (2):422-436.e5. doi: 10.1016/j.celrep.2019.08.097. PubMed PMID:31597101 PubMed Central PMC6919565.

Kuriappan, JA, Osheroff, N, De Vivo, M. Smoothed Potential MD Simulations for Dissociation Kinetics of Etoposide To Unravel Isoform Specificity in Targeting Human Topoisomerase II. J Chem Inf Model. 2019;59 (9):4007-4017. doi: 10.1021/acs.jcim.9b00605. PubMed PMID:31449404 PubMed Central PMC6800198.

Dalvie, ED, Gopas, J, Golan-Goldhirsh, A, Osheroff, N. 6,6'-Dihydroxythiobinupharidine as a poison of human type II topoisomerases. Bioorg Med Chem Lett. 2019;29 (15):1881-1885. doi: 10.1016/j.bmcl.2019.06.003. PubMed PMID:31182315 PubMed Central PMC6588444.

Gibson, EG, Bax, B, Chan, PF, Osheroff, N. Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase. ACS Infect Dis. 2019;5 (4):570-581. doi: 10.1021/acsinfecdis.8b00315. PubMed PMID:30757898 PubMed Central PMC6461504.

Jang, Y, Son, H, Lee, SW, Hwang, W, Jung, SR, Byl, JAW et al.. Selection of DNA Cleavage Sites by Topoisomerase II Results from Enzyme-Induced Flexibility of DNA. Cell Chem Biol. 2019;26 (4):502-511.e3. doi: 10.1016/j.chembiol.2018.12.003. PubMed PMID:30713098 PubMed Central PMC6474810.

Oviatt, AA, Kuriappan, JA, Minniti, E, Vann, KR, Onuorah, P, Minarini, A et al.. Polyamine-containing etoposide derivatives as poisons of human type II topoisomerases: Differential effects on topoisomerase IIα and IIβ. Bioorg Med Chem Lett. 2018;28 (17):2961-2968. doi: 10.1016/j.bmcl.2018.07.010. PubMed PMID:30006062 PubMed Central PMC6097886.

Gibson, EG, Blower, TR, Cacho, M, Bax, B, Berger, JM, Osheroff, N et al.. Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons. ACS Infect Dis. 2018;4 (8):1211-1222. doi: 10.1021/acsinfecdis.8b00035. PubMed PMID:29746087 PubMed Central PMC6309371.

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