Publications

Oviatt, AA, Collins, JA, Mann, CA, Huang, J, Mattern, K, Chan, PF et al.. Mechanism of Action of Gepotidacin: Well-Balanced Dual-Targeting against Gyrase and Topoisomerase IV in Cells and In Vitro. ACS Infect Dis. 2025;11 (11):3093-3105. doi: 10.1021/acsinfecdis.5c00497. PubMed PMID:41065178 PubMed Central PMC12624743.

Morgan, IL, Jian, JY, Osheroff, N, Neuman, KC. Bacterial type II topoisomerases cleave DNA in a species-specific manner. bioRxiv. 2025; :. doi: 10.1101/2025.07.28.667256. PubMed PMID:40766526 PubMed Central PMC12324340.

Mann, CA, Osheroff, N. DNA Cleavage Mediated by Bacterial Type II Topoisomerases. Methods Mol Biol. 2025;2928 :63-71. doi: 10.1007/978-1-0716-4550-5_6. PubMed PMID:40372637 PubMed Central PMC12183650.

Armenia, JF, Osheroff, N. DNA Decatenation Catalyzed by Bacterial Topoisomerase IV. Methods Mol Biol. 2025;2928 :51-61. doi: 10.1007/978-1-0716-4550-5_5. PubMed PMID:40372636 PubMed Central PMC12163102.

Joshi, S, Osheroff, N. DNA Supercoiling Catalyzed by Bacterial Gyrase. Methods Mol Biol. 2025;2928 :39-50. doi: 10.1007/978-1-0716-4550-5_4. PubMed PMID:40372635 PubMed Central PMC12154256.

Osheroff, N. Tips and Best Practices in Medical Education: Integrating Foundational and Clinical Sciences across the Medical Curriculum. Asia Pac Sch. 2025;10 (2):. doi: 10.29060/TAPS.2025-10-2/TT002. PubMed PMID:40271534 PubMed Central PMC12017601.

Mitton-Fry, MJ, Cummings, JE, Lu, Y, Armenia, JF, Byl, JAW, Oviatt, AA et al.. Anti-Mycobacterial Activity of Bacterial Topoisomerase Inhibitors with Dioxygenated Linkers. ACS Infect Dis. 2025;11 (2):474-482. doi: 10.1021/acsinfecdis.4c00743. PubMed PMID:39792935 PubMed Central PMC11834967.

Powell, JW, Mann, CA, Toth, PD, Nolan, S, Steinert, A, Ove, C et al.. Development of Novel Bacterial Topoisomerase Inhibitors Assisted by Computational Screening. ACS Med Chem Lett. 2024;15 (8):1287-1297. doi: 10.1021/acsmedchemlett.4c00162. PubMed PMID:39140037 PubMed Central PMC11318591.

Collins, JA, Basarab, GS, Chibale, K, Osheroff, N. Interactions between Zoliflodacin and Gyrase and Topoisomerase IV: Enzymological Basis for Cellular Targeting. ACS Infect Dis. 2024;10 (8):3071-3082. doi: 10.1021/acsinfecdis.4c00438. PubMed PMID:39082980 PubMed Central PMC11320581.

Oviatt, AA, Gibson, EG, Huang, J, Mattern, K, Neuman, KC, Chan, PF et al.. Interactions between Gepotidacin and Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting. ACS Infect Dis. 2024;10 (4):1137-1151. doi: 10.1021/acsinfecdis.3c00346. PubMed PMID:38606465 PubMed Central PMC11015057.

Collins, JA, Oviatt, AA, Chan, PF, Osheroff, N. Target-Mediated Fluoroquinolone Resistance in : Actions of Ciprofloxacin against Gyrase and Topoisomerase IV. ACS Infect Dis. 2024;10 (4):1351-1360. doi: 10.1021/acsinfecdis.4c00041. PubMed PMID:38606464 PubMed Central PMC11015056.

Collins, JA, Osheroff, N. Gyrase and Topoisomerase IV: Recycling Old Targets for New Antibacterials to Combat Fluoroquinolone Resistance. ACS Infect Dis. 2024;10 (4):1097-1115. doi: 10.1021/acsinfecdis.4c00128. PubMed PMID:38564341 PubMed Central PMC11019561.

Haramati, A, Bonaminio, G, Osheroff, N. Professional Identity Formation of Medical Science Educators: An Imperative for Academic Medicine. Med Sci Educ. 2024;34 (1):209-214. doi: 10.1007/s40670-023-01922-9. PubMed PMID:38510409 PubMed Central PMC10948639.

Deweese, JE, Osheroff, N. No Time to Relax and Unwind: Exploration of Topoisomerases and a Growing Field of Study. Int J Mol Sci. 2023;24 (17):. doi: 10.3390/ijms241713080. PubMed PMID:37685888 PubMed Central PMC10487853.

Dauda, SE, Collins, JA, Byl, JAW, Lu, Y, Yalowich, JC, Mitton-Fry, MJ et al.. Actions of a Novel Bacterial Topoisomerase Inhibitor against Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks. Int J Mol Sci. 2023;24 (15):. doi: 10.3390/ijms241512107. PubMed PMID:37569485 PubMed Central PMC10419083.

Brooks, JV, Dickinson, BL, Quesnelle, KM, Bonaminio, GA, Chalk-Wilayto, J, Dahlman, KB et al.. Professional Identity Formation of Basic Science Medical Educators: A Qualitative Study of Identity Supports and Threats. Acad Med. 2023;98 (11S):S14-S23. doi: 10.1097/ACM.0000000000005354. PubMed PMID:37556802 PubMed Central PMC10657385.

Jian, JY, Osheroff, N. Telling Your Right Hand from Your Left: The Effects of DNA Supercoil Handedness on the Actions of Type II Topoisomerases. Int J Mol Sci. 2023;24 (13):. doi: 10.3390/ijms241311199. PubMed PMID:37446377 PubMed Central PMC10342825.

Jian, JY, McCarty, KD, Byl, JAW, Guengerich, FP, Neuman, KC, Osheroff, N et al.. Basis for the discrimination of supercoil handedness during DNA cleavage by human and bacterial type II topoisomerases. Nucleic Acids Res. 2023;51 (8):3888-3902. doi: 10.1093/nar/gkad190. PubMed PMID:36999602 PubMed Central PMC10164583.

Byl, JAW, Mueller, R, Bax, B, Basarab, GS, Chibale, K, Osheroff, N et al.. A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Gyrase. ACS Infect Dis. 2023;9 (3):706-715. doi: 10.1021/acsinfecdis.3c00012. PubMed PMID:36802491 PubMed Central PMC10006343.

Bird, EC, Pettepher, CC, Ball, MAZ, Goswami, P, Lyons, E, Reed, SC et al.. Zooming into the COVID Era Together. Med Sci Educ. 2022;32 (5):1183-1188. doi: 10.1007/s40670-022-01611-z. PubMed PMID:36124041 PubMed Central PMC9476443.

Dalvie, ED, Stacy, JC, Neuman, KC, Osheroff, N. Recognition of DNA Supercoil Handedness during Catenation Catalyzed by Type II Topoisomerases. Biochemistry. 2022;61 (19):2148-2158. doi: 10.1021/acs.biochem.2c00370. PubMed PMID:36122251 PubMed Central PMC9548324.

Lu, Y, Mann, CA, Nolan, S, Collins, JA, Parker, E, Papa, J et al.. 1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum. ACS Med Chem Lett. 2022;13 (6):955-963. doi: 10.1021/acsmedchemlett.2c00111. PubMed PMID:35707162 PubMed Central PMC9189870.

Van Ravenstein, SX, Mehta, KP, Kavlashvili, T, Byl, JAW, Zhao, R, Osheroff, N et al.. Topoisomerase II poisons inhibit vertebrate DNA replication through distinct mechanisms. EMBO J. 2022;41 (12):e110632. doi: 10.15252/embj.2022110632. PubMed PMID:35578785 PubMed Central PMC9194788.

Govender, P, Müller, R, Singh, K, Reddy, V, Eyermann, CJ, Fienberg, S et al.. Spiropyrimidinetrione DNA Gyrase Inhibitors with Potent and Selective Antituberculosis Activity. J Med Chem. 2022;65 (9):6903-6925. doi: 10.1021/acs.jmedchem.2c00266. PubMed PMID:35500229 PubMed Central PMC9233935.

Huseman, ED, Byl, JAW, Chapp, SM, Schley, ND, Osheroff, N, Townsend, SD et al.. Synthesis and Cytotoxic Evaluation of Arimetamycin A and Its Daunorubicin and Doxorubicin Hybrids. ACS Cent Sci. 2021;7 (8):1327-1337. doi: 10.1021/acscentsci.1c00040. PubMed PMID:34471677 PubMed Central PMC8393218.

Osheroff, N. The COVID-19 Pandemic: a Year Lost, or a Year Found?. Med Sci Educ. 2021;31 (Suppl 1):21-26. doi: 10.1007/s40670-021-01392-x. PubMed PMID:34466278 PubMed Central PMC8390108.

Osheroff, N. Getting stressed over topoisomerase I poisons. Cell Chem Biol. 2021;28 (6):743-745. doi: 10.1016/j.chembiol.2021.04.015. PubMed PMID:34143956 PubMed Central PMC8445809.

Vann, KR, Oviatt, AA, Osheroff, N. Topoisomerase II Poisons: Converting Essential Enzymes into Molecular Scissors. Biochemistry. 2021;60 (21):1630-1641. doi: 10.1021/acs.biochem.1c00240. PubMed PMID:34008964 PubMed Central PMC8209676.

Collins, JA, Osheroff, N. 1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases. Chem Res Toxicol. 2021;34 (4):1082-1090. doi: 10.1021/acs.chemrestox.0c00492. PubMed PMID:33760604 PubMed Central PMC8058326.

Ortega, JA, Arencibia, JM, Minniti, E, Byl, JAW, Franco-Ulloa, S, Borgogno, M et al.. Novel, Potent, and Druglike Tetrahydroquinazoline Inhibitor That Is Highly Selective for Human Topoisomerase II α over β. J Med Chem. 2020;63 (21):12873-12886. doi: 10.1021/acs.jmedchem.0c00774. PubMed PMID:33079544 PubMed Central PMC7668297.

Search PubMed